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Publikováno v:
Clinical Materials. 13:121-130
Indomethacin-loaded nanocapsules were prepared by deposition of poly ( d,l -lactide) polymer (PLA) at the oil/water interface following acetone displacement from the oily nanodroplets. Rapid in-vitro release profiles of indomethacin from PLA nanocaps
Publikováno v:
The American journal of physiology. 263(1 Pt 2)
Intravenous bombesin produced a dose-related stimulation of luminal gastric somatostatin output and a concomitant dose-dependent inhibition of food intake in the gastric fistula cat. Maximal food intake inhibition was observed at 1,280 pmol.kg-1.h-1
Publikováno v:
Pharmaceutical research. 8(1)
The jejunal absorption of indomethacin nanocapsules was studied using an in vivo infusion technique. Jejunal absorption of indomethacin from the nanocapsules was slightly delayed as compared to a commercial indomethacin solution. The plasma and jejun
Publikováno v:
Gastroenterologie clinique et biologique. 15(10)
Secretin in known to inhibit gastric acid secretion. Exogenous secretin has also been shown to have a biphasic effect on acid secretion, being stimulatory then inhibitory. To explain this effect, we studied the timing of gastrin, somatostatin, and HC
Publikováno v:
Regulatory peptides. 31(1)
The half-life (t1/2) and metabolic clearance rate (MCR) of exogenous natural porcine oxyntomodulin (porcine OXM) and the synthetic analog of rat oxyntomodulin, [Nle27]-OXM (rat OXM), were compared with that of glucagon in control, sham-operated and a
Autor:
Maria Chicau-Chovet, M. Dubrasquet, Jeanne-Marie Lecomte, Annick Tsocas, Jacques Chariot, Claude Rozé
Publikováno v:
European Journal of Pharmacology. 154:247-254
Thiorphan and its prodrug, acetorphan, are two inhibitors of enkephalinase (EC 3.4.24.11), a membrane-bound peptidase which plays an important role in the metabolic degradation of enkephalins. Since exogenous opioids have been reported to both stimul
Publikováno v:
Gastroenterology. 79:659-664
The effects of intracerebroventricular injections of synthetic ovine β-endorphin were tested in conscious rats with gastric and pancreatic fistulas. In the range of 0.8 to 25 μg injected in the third ventricle of the brain, basal gastric and pancre