Zobrazeno 1 - 10
of 138
pro vyhledávání: '"M, Drerup"'
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101766- (2022)
Summary: In this protocol, we describe steps that utilize the optical clarity of the zebrafish larvae and the stereotyped motor neuron axon structure in the trunk to measure spontaneous or evoked motor neuron axon activity. This activity is detected
Externí odkaz:
https://doaj.org/article/46436a2e02374d13817c3a0321aeedda
Autor:
Dane Kawano, Katherine Pinter, Madison Chlebowski, Ronald S. Petralia, Ya-Xian Wang, Alex V. Nechiporuk, Catherine M. Drerup
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105072- (2022)
Summary: In the axon terminal, microtubule stability is decreased relative to the axon shaft. The dynamic microtubule plus ends found in the axon terminal have many functions, including serving as a docking site for the Cytoplasmic dynein motor. Here
Externí odkaz:
https://doaj.org/article/b65a0b263d814dbb8ca317db429152c9
Autor:
Jing Yang, Rong Li, Bin Yuan, Curtis A Clark, Bogang Wu, Justin M Drerup, Tianbao Li, Victor X Jin, Yanfen Hu, Tyler J Curiel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
BackgroundThe non-overlapping functions of the two estrogen receptor subtypes, ERα (Estrogen Receptor α)and ERβ (Estrogen Receptor β), in tumor cells have been studied extensively. However, their counterparts in host cells is vastly underinterrog
Externí odkaz:
https://doaj.org/article/9a99bc7f4fa646ec8701df65ded1023e
Publikováno v:
eLife, Vol 8 (2019)
The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor,
Externí odkaz:
https://doaj.org/article/53e5df06c6ce4567a21e501b970d0619
Autor:
Amrita Mandal, Catherine M. Drerup
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly i
Externí odkaz:
https://doaj.org/article/f10953438fff4c62b19a4bb5ebd72bcd
Autor:
Tyler J. Curiel, Ratna Vadlamudi, Rong Li, Vincent Hurez, Kathrin Thedieck, Mary Jo Turk, Yang Liu, Kruthi Murthy, José Conejo-Garcia, Alvaro Padron, Justin M. Drerup, Bin Yuan, Shunhua Lao, Srilakshmi Pandeswara, Gangadhara Sareddy, Harshita B. Gupta, Curtis A. Clark
PD-L1 antibodies produce efficacious clinical responses in diverse human cancers, but the basis for their effects remains unclear, leaving a gap in the understanding of how to rationally leverage therapeutic activity. PD-L1 is widely expressed in tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::654db7645d5b3a3e69a710be5c177f9f
https://doi.org/10.1158/0008-5472.c.6508806.v1
https://doi.org/10.1158/0008-5472.c.6508806.v1
Autor:
Tyler J. Curiel, Vincent Hurez, Aijie Liu, Shunhua Lao, Justin M. Drerup, Álvaro Padrón, Vinh Dao, Srilakshmi Pandeswara, Yang Liu
Supplementary figure 1. Rapamycin reduces EL4 bone marrow infiltration. Supplementary figure 2. HD rapamycin impairs T cell activation and infiltration. Supplementary figure 3. Effects of rapamycin on mTOR signals and Ki67 (proliferation) in EL4 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9beb2a9e1fb40249106dcd0fbcbdaa
https://doi.org/10.1158/0008-5472.22414907.v1
https://doi.org/10.1158/0008-5472.22414907.v1
Autor:
Tyler J. Curiel, Vincent Hurez, Aijie Liu, Shunhua Lao, Justin M. Drerup, Álvaro Padrón, Vinh Dao, Srilakshmi Pandeswara, Yang Liu
mTOR drives tumor growth but also supports T-cell function, rendering the applications of mTOR inhibitors complex especially in T-cell malignancies. Here, we studied the effects of the mTOR inhibitor rapamycin in mouse EL4 T-cell lymphoma. Typical ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33342dab130c5b1c5124abc930fdf652
https://doi.org/10.1158/0008-5472.c.6509114.v1
https://doi.org/10.1158/0008-5472.c.6509114.v1
Autor:
Tyler J. Curiel, Harshita Gupta, Vincent Hurez, José R. Conejo-Garcia, Wanjiao Chen, Curtis A. Clark, Aijie Liu, Jenny Mendez, Xinyue Zhang, Ryan M. Reyes, Álvaro S. Padrón, Sri Lakshmi Pandeswara, Yilun Deng, Justin M. Drerup
Supplementary figures 1-10. Figure S1. IL-2c increases conventional CD4 T cell in ascites three weeks after final IL-2c, but does not affect ascites Treg and effector T cell numbers at one week after final IL-2c administration. Figure S2. IL-2c treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20694f59c7c41b16c3b2836e23afff1c
https://doi.org/10.1158/0008-5472.22426258
https://doi.org/10.1158/0008-5472.22426258
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Despite their importance for cellular viability, the actual life history and properties of mitochondria in neurons are still unclear. These organelles are distributed throughout the entirety of the neuron and serve many functions, including: energy p
Externí odkaz:
https://doaj.org/article/36dc3bc41a2544d4bfb732f3800a77f4