Zobrazeno 1 - 10
of 354
pro vyhledávání: '"M, DeSilva"'
Autor:
Gabrielle M. Mey, Kirsten S. Evonuk, John Shelestak, Muhammad Irfan, Laura M. Wolfe, Sophia E. Laye, Dorothy P. Schafer, Tara M. DeSilva
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111226- (2024)
Summary: Multiple sclerosis (MS) is initially characterized by myelin and axonal damage in central nervous system white matter lesions, but their causal role in synapse loss remains undefined. Gray matter atrophy is also present early in MS, making i
Externí odkaz:
https://doaj.org/article/e9d006bcbc3e4c3888f9df711499d508
Autor:
Deanna R. Zhu, Alecia J. Rajesh, Rita M. Meganck, Ellen F. Young, Jennifer E. Munt, Victor L. Tse, Boyd Yount, Helen Conrad, Laura White, Sandra Henein, Aravinda M. DeSilva, Ralph S. Baric
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The DENV envelope (E) and pre-membrane (prM) glycoproteins are primary targets of serologic immunity after infection and vaccination. Of these, serotype-specific (TS) antibodies typically target E domains, while serotype cross-reactive (CR)
Externí odkaz:
https://doaj.org/article/eab47b3ba62a4f2eaf820d656fe74080
Autor:
Rita M Meganck, Deanna Zhu, Stephanie Dong, Lisa J Snoderly-Foster, Yago R Dalben, Devina Thiono, Laura J White, Arivianda M DeSilva, Ralph S Baric, Longping V Tse
Publikováno v:
eLife, Vol 12 (2023)
A hallmark of dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safet
Externí odkaz:
https://doaj.org/article/052e2b8492e2439d954641c9e43adbfa
Publikováno v:
Royal Society Open Science, Vol 10, Iss 9 (2023)
The forelimbs of hominoid primates (apes) are decidedly more flexible than those of monkeys, especially at the shoulder, elbow and wrist joints. It is tempting to link the greater mobility of these joints to the functional demands of vertical climbin
Externí odkaz:
https://doaj.org/article/46ab18360b3245719a183e5f6d3cd37d
Autor:
Gabrielle M. Mey, Kirsten S. Evonuk, McKenzie K. Chappell, Laura M. Wolfe, Rupesh Singh, Julia C. Batoki, Minzhong Yu, Neal S. Peachey, Bela Anand-Apte, Robert Bermel, Daniel Ontaneda, Kunio Nakamura, Kedar R. Mahajan, Tara M. DeSilva
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive connectivity throughout the central nervous system (CNS). Using a model of autoimmune dem
Externí odkaz:
https://doaj.org/article/d1f51e11e09742c58a6739f3748c0f61
Autor:
Gabrielle M. Mey, Tara M. DeSilva
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neurodegeneration occurs early in the multiple sclerosis (MS) disease course and is an important driver of permanent disability. Current immunomodulatory therapies do not directly target neuronal health; thus, there is a critical need to develop neur
Externí odkaz:
https://doaj.org/article/bb2c0501bdf54bb0a0fb12d9a31bffdc
Publikováno v:
Evolutionary Human Sciences, Vol 4 (2022)
Bipedal locomotion is a hallmark of being human. Yet the body form from which bipedalism evolved remains unclear. Specifically, the positional behaviour (i.e. orthograde vs. pronograde) and the length of the lumbar spine (i.e. long and mobile vs. sho
Externí odkaz:
https://doaj.org/article/265cbbf1da314742963fc8f73e727815
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 37 (2022)
We asked whether hyperoxia might induce hypomyelination of the corpus callosum, clinically described as periventricular leukomalacia (PVL) of the severely preterm infant. Mouse pups and their nursing dams were placed in 80% oxygen from P4-P8, then re
Externí odkaz:
https://doaj.org/article/516e198bc24346d0b0ecfc2ee8abf5a9
Autor:
Gabrielle M. Mey, Kirsten S. Evonuk, McKenzie K. Chappell, Laura M. Wolfe, Rupesh Singh, Julia C. Batoki, Minzhong Yu, Neal S. Peachey, Bela Anand‑Apte, Robert Bermel, Daniel Ontaneda, Kunio Nakamura, Kedar R. Mahajan, Tara M. DeSilva
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/5fa399d81b7a47ffb4894f89249b8d0f
Autor:
Michael C. Everett, Marina C. Elliott, David Gaynor, Austin C. Hill, Samar M. Syeda, Jesse Casana, Bernhard Zipfel, Jeremy M. DeSilva, Nathaniel J. Dominy
Publikováno v:
South African Journal of Science, Vol 117, Iss 11/12 (2021)
Mechanical loading of finger bones (phalanges) can induce angular curvature, which benefits arboreal primates by dissipating forces and economising the recruitment of muscles during climbing. The recent discovery of extremely curved phalanges in a ho
Externí odkaz:
https://doaj.org/article/77a32e8eec3347ac908836b72f87645b