Zobrazeno 1 - 10
of 32
pro vyhledávání: '"M, De Groof"'
Autor:
Łukasz Mateusiak, Sam Floru, Timo W. M. De Groof, Janne Wouters, Noemi B. Declerck, Pieterjan Debie, Simone Janssen, Katty Zeven, Janik Puttemans, Cécile Vincke, Karine Breckpot, Nick Devoogdt, Sophie Hernot
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Fluorescence molecular imaging plays a vital role in image‐guided surgery. In this context, the urokinase plasminogen activator receptor (uPAR) is an interesting biomarker enabling the detection and delineation of various tumor types due t
Externí odkaz:
https://doaj.org/article/a377899d68f44206a97cf26504119978
Autor:
Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background The opening of pannexin1 channels is considered as a key event in inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers inflammasome signaling and activation of immune cells. By doing so, pannexin1 ch
Externí odkaz:
https://doaj.org/article/8b9134db02464ebd9b9cd759de219169
Autor:
Heleen Hanssens, Fien Meeus, Yannick De Vlaeminck, Quentin Lecocq, Janik Puttemans, Pieterjan Debie, Timo W. M. De Groof, Cleo Goyvaerts, Kim De Veirman, Karine Breckpot, Nick Devoogdt
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMultiple myeloma (MM) remains incurable, despite the advent of chimeric antigen receptor (CAR)-T cell therapy. This unfulfilled potential can be attributed to two untackled issues: the lack of suitable CAR targets and formats. In relation
Externí odkaz:
https://doaj.org/article/3d9c11bb3b93466ea2e047b61538c6b5
Autor:
Timo W. M. De Groof, Elizabeth G. Elder, Eleanor Y. Lim, Raimond Heukers, Nick D. Bergkamp, Ian J. Groves, Mark Wills, John H. Sinclair, Martine J. Smit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and sh
Externí odkaz:
https://doaj.org/article/f6e7b525a9434aba8b55e7c5d8bcbd9e
Autor:
Timo W. M. De Groof, Nick D. Bergkamp, Raimond Heukers, Truc Giap, Maarten P. Bebelman, Richard Goeij-de Haas, Sander R. Piersma, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Marco Siderius, Martine J. Smit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Various GPCRs display constitutive ligand-independent activity, but it remains unclear whether ligand-dependent and -independent conformations differ. Here the authors demonstrate the recognition and blocking of G protein recruitment of either the li
Externí odkaz:
https://doaj.org/article/e627ed6b73f44763bda4541f3d3a971b
Autor:
Cyprine Neba Funeh, Jessica Bridoux, Thomas Ertveldt, Timo W. M. De Groof, Dora Mugoli Chigoho, Parinaz Asiabi, Peter Covens, Matthias D’Huyvetter, Nick Devoogdt
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1378 (2023)
The precise delivery of cytotoxic radiation to cancer cells through the combination of a specific targeting vector with a radionuclide for targeted radionuclide therapy (TRT) has proven valuable for cancer care. TRT is increasingly being considered a
Externí odkaz:
https://doaj.org/article/7e082e107da44442bddd824859fcc36e
Autor:
Robin Maximilian, Awad, Fien, Meeus, Hannelore, Ceuppens, Thomas, Ertveldt, Heleen, Hanssens, Quentin, Lecocq, Lukasz, Mateusiak, Katty, Zeven, Hana, Valenta, Timo W M, De Groof, Yannick, De Vlaeminck, Ahmet, Krasniqi, Kim, De Veirman, Cleo, Goyvaerts, Matthias, D'Huyvetter, Sophie, Hernot, Nick, Devoogdt, Karine, Breckpot
Publikováno v:
International review of cell and molecular biology. 369
Cancer is a heterogeneous disease, requiring treatment tailored to the unique phenotype of the patient's tumor. Monoclonal antibodies (mAbs) and variants thereof have enabled targeted therapies to selectively target cancer cells. Cancer cell-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5efb9206e5f2b488b5acb059570c4402
https://pubmed.ncbi.nlm.nih.gov/35777863
https://pubmed.ncbi.nlm.nih.gov/35777863
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2451
Photosensitizers have recently been conjugated to nanobodies for targeted photodynamic therapy (PDT) to selectively kill cancer cells. The success of this approach relies on nanobody-photosensitizer conjugates that bind specifically to their targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6af6cf1eb2ebfc739c868a16d2176715
https://pubmed.ncbi.nlm.nih.gov/35505028
https://pubmed.ncbi.nlm.nih.gov/35505028
Publikováno v:
Occupational and Environmental Medicine. 57:19-27
BACKGROUND—A patient with unexplained minor behavioural changes associated with an axonal sensorimotor polyneuropathy had a history of chronic occupational exposure to cadmium (Cd). Although animal studies have shown that Cd is a potent neurotoxica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aae12c92cff9945e123d1c7b8fdb52b
https://doi.org/10.1136/oem.57.1.19
https://doi.org/10.1136/oem.57.1.19
Publikováno v:
American Journal of Industrial Medicine. 31:645-652
The study aimed at assessing the evolution of cadmium (Cd)-induced renal tubular dysfunction in Cd workers according to the severity of the microproteinuria observed at the time the exposure was substantially decreased. Male workers employed in the C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c882ae364ad0b397af83afcc8789802e
https://doi.org/10.1002/(sici)1097-0274(199705)31:5<645::aid-ajim21>3.0.co
https://doi.org/10.1002/(sici)1097-0274(199705)31:5<645::aid-ajim21>3.0.co