Zobrazeno 1 - 10
of 917
pro vyhledávání: '"M, Davidoff"'
Autor:
Luca Pio, Celine Richard, Tarek Zaghloul, Andrew J. Murphy, Andrew M. Davidoff, Abdelhafeez H. Abdelhafeez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-5 (2024)
Abstract Sentinel lymph node biopsy (SLNB) is an important technique in the staging of pediatric melanomas, sarcomas, and potentially useful for other solid tumors. Precise visual localization of the sentinel lymph node (SLN) during the operation is
Externí odkaz:
https://doaj.org/article/c325d6e857e24f1089f633a775b6ef68
Autor:
Sara A. Mansfield, Meera Kotagal, Stephen Hartman, Andrew J. Murphy, Andrew M. Davidoff, Doralina L. Anghelescu, Marc Mecoli, Nicholas Cost, Brady Hogan, Kyle O. Rove
Publikováno v:
Frontiers in Surgery, Vol 11 (2024)
IntroductionEnhanced recovery after surgery (ERAS) is an evidence-based, multi-modal approach to decrease surgical stress, expedite recovery, and improve postoperative outcomes. ERAS is increasingly being utilized in pediatric surgery. Its applicabil
Externí odkaz:
https://doaj.org/article/c33c7cddb87444fcb71ec9e3a1430af2
Autor:
Andrew J. Murphy, Changde Cheng, Justin Williams, Timothy I. Shaw, Emilia M. Pinto, Karissa Dieseldorff-Jones, Jack Brzezinski, Lindsay A. Renfro, Brett Tornwall, Vicki Huff, Andrew L. Hong, Elizabeth A. Mullen, Brian Crompton, Jeffrey S. Dome, Conrad V. Fernandez, James I. Geller, Peter F. Ehrlich, Heather Mulder, Ninad Oak, Jamie Maciezsek, Carolyn M. Jablonowski, Andrew M. Fleming, Prahalathan Pichavaram, Christopher L. Morton, John Easton, Kim E. Nichols, Michael R. Clay, Teresa Santiago, Jinghui Zhang, Jun Yang, Gerard P. Zambetti, Zhaoming Wang, Andrew M. Davidoff, Xiang Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Developing synchronous bilateral Wilms tumor suggests an underlying (epi)genetic predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or genome sequencing (n = 85 tumors from 61 patients with matched germlin
Externí odkaz:
https://doaj.org/article/946f460fad5e41959f9465bb4f236137
Autor:
Carolyn M Jablonowski, Waise Quarni, Shivendra Singh, Haiyan Tan, Dhanushka Hewa Bostanthirige, Hongjian Jin, Jie Fang, Ti-Cheng Chang, David Finkelstein, Ji-Hoon Cho, Dongli Hu, Vishwajeeth Pagala, Sadie Miki Sakurada, Shondra M Pruett-Miller, Ruoning Wang, Andrew Murphy, Kevin Freeman, Junmin Peng, Andrew M Davidoff, Gang Wu, Jun Yang
Publikováno v:
eLife, Vol 12 (2024)
Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how p
Externí odkaz:
https://doaj.org/article/56c3296c6a1943a796dba4f0a49cdf21
Autor:
Jie Fang, Shivendra Singh, Changde Cheng, Sivaraman Natarajan, Heather Sheppard, Ahmed Abu-Zaid, Adam D. Durbin, Ha Won Lee, Qiong Wu, Jacob Steele, Jon P. Connelly, Hongjian Jin, Wenan Chen, Yiping Fan, Shondra M. Pruett-Miller, Jerold E. Rehg, Selene C. Koo, Teresa Santiago, Joseph Emmons, Stefano Cairo, Ruoning Wang, Evan S. Glazer, Andrew J. Murphy, Taosheng Chen, Andrew M. Davidoff, Carolina Armengol, John Easton, Xiang Chen, Jun Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that re
Externí odkaz:
https://doaj.org/article/518df2bf603d4dbaa5922a65b63e4a51
Autor:
Daniel B. Gehle, Zachary D. Morrison, Huma F. Halepota, Akshita Kumar, Clark Gwaltney, Matthew J. Krasin, Dylan E. Graetz, Teresa Santiago, Umar S. Boston, Andrew M. Davidoff, Andrew J. Murphy
Publikováno v:
Children, Vol 11, Iss 8, p 896 (2024)
Wilms tumor (WT) is the most common kidney tumor in pediatric patients. Intravascular extension of WT above the level of the renal veins is a rare manifestation that complicates surgical management. Patients with intravascular extension are frequentl
Externí odkaz:
https://doaj.org/article/ca925115b41b4b98b25691800b155b98
Autor:
John Thomas Lucas, Jr., Daniel Victor Wakefield, Michael Doubrovin, Yimei Li, Teresa Santiago, Sara Michele Federico, Thomas E. Merchant, Andrew M. Davidoff, Matthew J. Krasin, Barry L. Shulkin, Victor M. Santana, Wayne Lee Furman
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 34, Iss , Pp 42-50 (2022)
Purpose: This retrospective study sought to identify predictors of metastatic site failure (MSF) at new and/or original (present at diagnosis) sites in high-risk neuroblastoma patients. Methods and materials: Seventy-six high-risk neuroblastoma patie
Externí odkaz:
https://doaj.org/article/6ade4831c50140b89f8a8b0af0478d55
Autor:
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A. Brimble, Samantha D. Creighton, Timothy A. B. McLean, Meaghan Hall, Krista A. Mitchnick, Jacqueline Zakaria, Thanh Phung, Anas Reda, Amanda M. Leonetti, Ashley Monks, Lara Ianov, Boyer D. Winters, Brandon J. Walters, Andrew M. Davidoff, Jennifer A. Mitchell, Iva B. Zovkic
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The structurally-unique histone variant, mH2A1, influences learning and memory in mice to a greater extent than a similar variant, mH2A2.
Externí odkaz:
https://doaj.org/article/d840a5d938684f1fae4467b25c62e8a3
Autor:
Mark A. Brimble, Pei-Hsin Cheng, Stephen M. Winston, Isaiah L. Reeves, Aisha Souquette, Yunyu Spence, Junfang Zhou, Yong-Dong Wang, Christopher L. Morton, Marcus Valentine, Paul G. Thomas, Amit C. Nathwani, John T. Gray, Andrew M. Davidoff
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 280-291 (2022)
Recombinant adeno-associated virus (rAAV) vectors are increasingly being used for clinical gene transfer and have shown great potential for the treatment of several monogenic disorders. However, contaminant DNA from producer plasmids can be packaged
Externí odkaz:
https://doaj.org/article/9ce90bd19a374a6086d2a19259d8a399
Autor:
Alexandra D’Oto, Jie Fang, Hongjian Jin, Beisi Xu, Shivendra Singh, Anoushka Mullasseril, Victoria Jones, Ahmed Abu-Zaid, Xinyu von Buttlar, Bailey Cooke, Dongli Hu, Jason Shohet, Andrew J. Murphy, Andrew M. Davidoff, Jun Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The histone demethylase KDM6B is reported to be essential for neuroblastoma cell survival. Here the authors show that KDM6B regulates CDK4/6-pRB-E2F pathway through H3K27me3-dependent enhancer-promoter interactions in neuroblastoma.
Externí odkaz:
https://doaj.org/article/2ad9ab2b23fe41648721a58a68144d5b