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Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

Autor: Martina Zobel, Y Rolland, Juri Rappsilber, Anna Lena Illert, Chiara Giuliani, M Cinquanta, Eugenio Santos, S Kreutmair, Giancarlo Pruneri, Emanuela Frittoli, Giorgio Scita, Saverio Minucci, Carmela Gómez, Mogjiborahman Salek, Isabella Pallavicini, Flavia Troglio, Silke Gerboth, Andrea Palamidessi, Fernando C. Baltanás

Publikováno v: Gerboth, S, Frittoli, E, Palamidessi, A, Baltanas, F C, Salek, M, Rappsilber, J, Giuliani, C, Troglio, F, Rolland, Y, Pruneri, G, Kreutmair, S, Pallavicini, I, Zobel, M, Cinquanta, M, Minucci, S, Gomez, C, Santos, E, Illert, A L & Scita, G 2017, ' Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis ', Leukemia, vol. 32, no. 3, pp. 820-827 . https://doi.org/10.1038/leu.2017.267
Digital.CSIC. Repositorio Institucional del CSIC
instname
Leukemia

Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 acquires RAC GEF activity and what is the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb12c63e4dffbd9e5bca4d69d3fc5d5
https://hdl.handle.net/20.500.11820/bc8340f1-0ae4-4c45-b4ed-5e0ef373b63b

Carrier-mediated Serotonin Release Induced by d-Fenfluramine: Studies with Human Neuroblastoma Cells Transfected with a Rat Serotonin Transporter

Autor: M. Cinquanta, Tiziana Mennini, Marco Gobbi, T Ratovitski, Rabi Simantov, D. Crespi

Publikováno v: Neuropharmacology. 36:803-809

The NMB human neuronal cell line, transfected with a newly prepared plasmid expressing rat serotonin transporter (NMB-rSERT), shows specific [3H]5-HT uptake which is blocked by citalopram and fenfluramine (F) stereoisomers with ic 50 values (1 nM, 0.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4459f37f7d1ae4123040780b4eda2f
https://doi.org/10.1016/s0028-3908(97)00064-6

Effects of Ultra-High-Pressure Treatment on Chemical Composition and Biological Activities of Free, Esterified and Bound Phenolics from Phyllanthus emblica L. Fruits.

Autor: Taiming Chen¹ (AUTHOR) ming19970515@163.com, Shuyue He² (AUTHOR) kmlgdx303@163.com, Jing Zhang¹ (AUTHOR) z1241742925@163.com, Huangxin Wang¹ (AUTHOR) whx9806@126.com, Yiqing Jia¹ (AUTHOR) jiaq7207@163.com, Yaping Liu¹ (AUTHOR) liuyaping@kust.edu.cn, Mingjun Xie³ (AUTHOR) tahe1111@kust.edu.cn, Guiguang Cheng¹ (AUTHOR) ggcheng@kust.edu.cn

Publikováno v: Molecules. Jul2024, Vol. 29 Issue 13, p1-17. 17p. 2 Charts, 9 Graphs.

Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium

Autor: D K, Ornstein, M, Cinquanta, S, Weiler, P H, Duray, M R, Emmert-Buck, C D, Vocke, W M, Linehan, J A, Ferretti

Publikováno v: The Journal of urology. 165(4)

The NKX-3.1gene is an androgen regulated prostate specific homeobox gene that is believed to have a vital role in normal prostate development. In mice the homologue NKx3.1 is exclusively expressed in prostate epithelium. In humans NKX3.1 expression i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::816bb796593ca0abaa1613949815c41f
https://pubmed.ncbi.nlm.nih.gov/11257711