Zobrazeno 1 - 10
of 1 742
pro vyhledávání: '"M, Castelli"'
Autor:
Brett D. Baker, Darla M. Castelli
Publikováno v:
Frontiers in Cognition, Vol 3 (2024)
IntroductionPhysical activity is known to enhance cognitive functioning across the lifespan, yet the effects of sedentary behaviors on cognitive functioning remain unclear. The purpose of this study was to determine how an acute daily bout of prolong
Externí odkaz:
https://doaj.org/article/a66790d1a3354f50b3960158588e02b3
Publikováno v:
AJPM Focus, Vol 3, Iss 3, Pp 100202- (2024)
Introduction: The novel COVID-19 disease detected in 2019 widely affected individuals’ social movements, likely disrupting the ability to participate in leisure-related physical activity. Because of this, participation in sedentary behavior is thou
Externí odkaz:
https://doaj.org/article/14350bcee8954166893e4ce008b78610
Autor:
Simeon R. Mihaylov, Lydia M. Castelli, Ya-Hui Lin, Aytac Gül, Nikita Soni, Christopher Hastings, Helen R. Flynn, Oana Păun, Mark J. Dickman, Ambrosius P. Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A. Shelkovnikova, Heather Mortiboys, Sila K. Ultanir, Guillaume M. Hautbergue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a se
Externí odkaz:
https://doaj.org/article/d4c65c08085643d58fc9598614996598
Autor:
Scott P. Allen, Afnan Al Sultan, Elaine Kabucho Kibirige, Erin Tonkiss, Keaton J. Hamer, Lydia M. Castelli, Ya-Hui Lin, Sarah Roscoe, Nikolaos Stefanidis, Richard J. Mead, J. Robin Highley, Johnathan Cooper-Knock, Guillaume M. Hautbergue, Paul R. Heath, Janine Kirby, Pamela J. Shaw
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
A p.Y374X truncation in TARDBP was recently shown to reduce expression of TDP43 in fibroblasts isolated from ALS cases. In this follow up study focused on assessing the downstream phenotypic consequences of loss of TDP43 in the context of the truncat
Externí odkaz:
https://doaj.org/article/ca2ad4e34a5b4061a9d5da2449950735
Autor:
Claudia S. Bauer, Christopher P. Webster, Allan C. Shaw, Jannigje R. Kok, Lydia M. Castelli, Ya-Hui Lin, Emma F. Smith, Francisco Illanes-Álvarez, Adrian Higginbottom, Pamela J. Shaw, Mimoun Azzouz, Laura Ferraiuolo, Guillaume M. Hautbergue, Andrew J. Grierson, Kurt J. De Vos
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Disruption to protein homeostasis caused by lysosomal dysfunction and associated impairment of autophagy is a prominent pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). The most common genetic cause of ALS/FTD is a G4
Externí odkaz:
https://doaj.org/article/a7f7ea91bf69440699e3334d2a8e3cbe
Autor:
Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing
Externí odkaz:
https://doaj.org/article/d1a033da7da847f699478c811b28f10b
Autor:
Ebelechukwu C. Nwokoye, Eiman AlNaseem, Robert A. Crawford, Lydia M. Castelli, Martin D. Jennings, Christopher J. Kershaw, Graham D. Pavitt
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract By interacting with the mRNA 5′ cap, the translation initiation factor eIF4E plays a critical role in selecting mRNAs for protein synthesis in eukaryotic cells. Caf20 is a member of the family of proteins found across eukaryotes termed 4E-
Externí odkaz:
https://doaj.org/article/a170f8d568954ea3bc06d0d1845d3a9b
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Short repeated sequences of 3−6 nucleotides are causing a growing number of over 50 microsatellite expansion disorders, which mainly present with neurodegenerative features. Although considered rare diseases in relation to the relatively low number
Externí odkaz:
https://doaj.org/article/3d3e8c2d6a29401e9c075e7c7768ab06
Publikováno v:
Behavioral Sciences, Vol 13, Iss 3, p 210 (2023)
Background: Based on the Health Belief Model, this study examined preservice teacher attributes and attitudes toward providing physical activity opportunities for children in school. Methods: A quasi-experimental design was used to collect proof of c
Externí odkaz:
https://doaj.org/article/5b18852f856947279e16d6e4b5b7ae04
Autor:
Hayley J. Nell, Laura M. Castelli, Dino Bertani, Aaron A. Jipson, Sean F. Meagher, Luana T. Melo, Karl Zabjek, W. Darlene Reid
Publikováno v:
BMC Sports Science, Medicine and Rehabilitation, Vol 12, Iss 1, Pp 1-10 (2020)
Abstract Background Decreased oxygenation of muscle may be accentuated during exercise at high altitude. Monitoring the oxygen saturation of muscle (SmO2) during hand grip exercise using near infrared spectroscopy during acute exposure to hypoxia cou
Externí odkaz:
https://doaj.org/article/985ac6f5b78a48a3b753f40aa38fe681