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Akademický článek

Inferring upstream regulatory genes of FOXP3 in human regulatory T cells from time-series transcriptomic data

Autor: Stefano Magni, Rucha Sawlekar, Christophe M. Capelle, Vera Tslaf, Alexandre Baron, Ni Zeng, Laurent Mombaerts, Zuogong Yue, Ye Yuan, Feng Q. Hefeng, Jorge Gonçalves

Publikováno v: npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)

Abstract The discovery of upstream regulatory genes of a gene of interest still remains challenging. Here we applied a scalable computational method to unbiasedly predict candidate regulatory genes of critical transcription factors by searching the w

Externí odkaz: https://doaj.org/article/ed7e7d476a09458eb90fc0009e2c3a12

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Akademický článek

Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Neuroinflammation in the brain contributes to the pathogenesis of Parkinson’s disease (PD), but the potential dysregulation of peripheral immunity has not been systematically investigated for idiopathic PD (iPD). Here we showed an elevated

Externí odkaz: https://doaj.org/article/9c76c6ec5f87413db781581ee546fe6e

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Akademický článek

Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells

Autor: Christophe M. Capelle, Ni Zeng, Egle Danileviciute, Sabrina Freitas Rodrigues, Markus Ollert, Rudi Balling, Feng Q. He

Publikováno v: iScience, Vol 24, Iss 4, Pp 102289- (2021)

Summary: Many players regulating the CD4+ T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a

Externí odkaz: https://doaj.org/article/4add58a0cf834c9c8900a476cf93ea34

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Akademický článek

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DJ-1 depletion prevents immunoaging in T-cell compartments

Autor: Ni Zeng, Christophe M Capelle, Alexandre Baron, Takumi Kobayashi, Severine Cire, Vera Tslaf, Cathy Leonard, Djalil Coowar, Haruhiko Koseki, Astrid M Westendorf, Jan Buer, Dirk Brenner, Rejko Krüger, Rudi Balling, Markus Ollert, Feng Q Hefeng

Publikováno v: Zeng, N, Capelle, C M, Baron, A, Kobayashi, T, Cire, S, Tslaf, V, Leonard, C, Coowar, D, Koseki, H, Westendorf, A M, Buer, J, Brenner, D, Krüger, R, Balling, R, Ollert, M & Hefeng, F Q 2022, ' DJ-1 depletion prevents immunoaging in T-cell compartments ', EMBO Reports, vol. 23, no. 3, e53302 . https://doi.org/10.15252/embr.202153302

Decline in immune function during aging increases susceptibility to different aging-related diseases. However, the underlying molecular mechanisms, especially the genetic factors contributing to imbalance of naïve/memory T-cell subpopulations, still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e5fe06fa50ef80c1ef1beaecaf5940
https://findresearcher.sdu.dk:8443/ws/files/197720118/EMBO_Reports_2022_Zeng_DJ_1_depletion_prevents_immunoaging_in_T_cell_compartments.pdf

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Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1

Autor: Christophe M. Capelle, Anna Chen, Ni Zeng, Alexandre Baron, Kamil Grzyb, Thais Arns, Alexander Skupin, Markus Ollert, Feng Q. Hefeng

Publikováno v: Capelle, C M, Chen, A, Zeng, N, Baron, A, Grzyb, K, Arns, T, Skupin, A, Ollert, M & Hefeng, F Q 2022, ' Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1 ', Immunology, vol. 165, no. 4, pp. 428-444 . https://doi.org/10.1111/imm.13448

Stress hormones are believed to skew the CD4 T-cell differentiation towards a Th2 response via a T-cell-extrinsic mechanism. Using isolated primary human naïve and memory CD4 T cells, here we show that both adrenergic- and glucocorticoid-mediated st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb3fed57211c1b36adfa6ca2cf599d7
https://www.ncbi.nlm.nih.gov/pubmed/35143696

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Standard PBMC cryopreservation selectively decreases detection of nine clinically-relevant T-cell markers

Autor: Christophe M. Capelle, Séverine Cire, Wim Ammerlaan, Maria Konstantinou, Rudi Balling, Fay Betsou, Antonio Cosma, Markus Ollert, Feng Q. Hefeng

Biobanking is an operational component of various epidemiological studies and clinical trials. Although peripheral blood is routinely acquired and stored in biobanks, the effects of specimen processing on cell composition and clinically-relevant func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43e139766e1ca0c4387d013fabc47967
https://doi.org/10.1101/2021.05.18.443634

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Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Publikováno v: Capelle, C M, Ciré, S, Domingues, O, Ernens, I, Hedin, F, Fischer, A, Snoeck, C J, Ammerlaan, W, Konstantinou, M, Grzyb, K, Skupin, A, Carty, C L, Hilger, C, Gilson, G, Celebic, A, Wilmes, P, Del Sol, A, Kaplan, I M, Betsou, F, Abdelrahman, T, Cosma, A, Vaillant, M, Fagherazzi, G, Ollert, M & Hefeng, F Q 2022, ' Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients ', Cell Reports Medicine, vol. 3, no. 4, 100600 . https://doi.org/10.1016/j.xcrm.2022.100600

While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely elusive. We systematically analyze 484 peripheral cellular or soluble immune features in a longitudina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18e7bf892ea4f97477ba8eb53ae07af
https://doi.org/10.1016/j.xcrm.2022.100600

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