Zobrazeno 1 - 10
of 443
pro vyhledávání: '"M, Bosio"'
Autor:
Jade C. Riopelle, Amirhossein Shamsaddini, Myndi G. Holbrook, Eric Bohrnsen, Yue Zhang, Jamie Lovaglio, Kathleen Cordova, Patrick Hanley, Lon V. Kendall, Catharine M. Bosio, Tony Schountz, Benjamin Schwarz, Vincent J. Munster, Julia R. Port
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The intestinal microbiome plays an important role in mammalian health, disease, and immune function. In light of this function, recent studies have aimed to characterize the microbiomes of various bat species, which are noteworthy for their
Externí odkaz:
https://doaj.org/article/3f00406f27a048499778d34600fe701a
Autor:
Anne Ward, Forrest Jessop, Robert Faris, Jason Hollister, Daniel Shoup, Brent Race, Catharine M Bosio, Suzette A Priola
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298095 (2024)
The PINK1/Parkin pathway of mitophagy has been implicated in the pathogenesis of Parkinson's disease. In prion diseases, a transmissible neurodegenerative disease caused by the misfolded and infectious prion protein (PrPSc), expression of both PINK1
Externí odkaz:
https://doaj.org/article/598e0040e30a4b93b9876823043878ef
Autor:
Kyle Rosenke, Matt C. Lewis, Friederike Feldmann, Eric Bohrnsen, Benjamin Schwarz, Atsushi Okumura, W. Forrest Bohler, Julie Callison, Carl Shaia, Catharine M. Bosio, Jamie Lovaglio, Greg Saturday, Michael A. Jarvis, Heinz Feldmann
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule inhibitors, molnupiravir (MK
Externí odkaz:
https://doaj.org/article/8c4c6d11714643ca966ef175993be046
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0293450 (2023)
Route of exposure to pathogens can inform divergent disease pathogenesis and mortality rates. However, the features that contribute to these differences are not well established. Host metabolism has emerged as a critical element governing susceptibil
Externí odkaz:
https://doaj.org/article/bcab7d6c734043fa8b30d677f7743992
Autor:
Simote T Foliaki, Anna Smith, Benjamin Schwarz, Eric Bohrnsen, Catharine M Bosio, Katie Williams, Christina D Orrú, Hailey Lachenauer, Bradley R Groveman, Cathryn L Haigh
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010565 (2023)
Fatal familial insomnia (FFI) is a rare neurodegenerative disease caused by a dominantly inherited single amino acid substitution (D178N) within the prion protein (PrP). No in vitro human brain tissue model for this disease has previously been availa
Externí odkaz:
https://doaj.org/article/5f44df8f953e4e0d8120b3a7928318d2
Autor:
Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll, Cathryn L. Haigh
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals wi
Externí odkaz:
https://doaj.org/article/6bd0dd66c2cd46cbb517d6bd6b03291d
Autor:
Andrea C. Bohrer, Ehydel Castro, Claire E. Tocheny, Maike Assmann, Benjamin Schwarz, Eric Bohrnsen, Michelle A. Makiya, Fanny Legrand, Kerry L. Hilligan, Paul J. Baker, Flor Torres-Juarez, Zhidong Hu, Hui Ma, Lin Wang, Liangfei Niu, Zilu Wen, Sang H. Lee, Olena Kamenyeva, Keith D. Kauffman, Michele Donato, Alan Sher, Daniel L. Barber, Laura E. Via, Thomas J. Scriba, Purvesh Khatri, Yanzheng Song, Ka-Wing Wong, Catharine M. Bosio, Amy D. Klion, Katrin D. Mayer-Barber
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111144- (2022)
Summary: Influx of eosinophils into the lungs is typically associated with type II responses during allergy and fungal and parasitic infections. However, we previously reported that eosinophils accumulate in lung lesions during type I inflammatory re
Externí odkaz:
https://doaj.org/article/4cc9d670630f4c0ab39dbfc2f415fe75
Autor:
Kyle Rosenke, Frederick Hansen, Benjamin Schwarz, Friederike Feldmann, Elaine Haddock, Rebecca Rosenke, Kent Barbian, Kimberly Meade-White, Atsushi Okumura, Shanna Leventhal, David W. Hawman, Emily Ricotta, Catharine M. Bosio, Craig Martens, Greg Saturday, Heinz Feldmann, Michael A. Jarvis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
While vaccines protecting against SARS-CoV-2 infection are approved, currently, there are no drugs suitable for high-risk exposure use against SARS-CoV-2. Here, Rosenke et al. provide evidence that orally delivered MK-4482, a nucleoside analog, inhib
Externí odkaz:
https://doaj.org/article/9a78a63a312847aa863ae1016f4d581a
Autor:
Dan Drecktrah, Laura S Hall, Bethany Crouse, Benjamin Schwarz, Crystal Richards, Eric Bohrnsen, Michael Wulf, Bonnie Long, Jessica Bailey, Frank Gherardini, Catharine M Bosio, Meghan C Lybecker, D Scott Samuels
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010385 (2022)
We have identified GpsA, a predicted glycerol-3-phosphate dehydrogenase, as a virulence factor in the Lyme disease spirochete Borrelia (Borreliella) burgdorferi: GpsA is essential for murine infection and crucial for persistence of the spirochete in
Externí odkaz:
https://doaj.org/article/47aa20de68904d7fa81e1d4307afbf65
Autor:
M. Bosio, B. Souza-Chaves, J. Gomes, M. Gmurek, R. Martins, E. Saggioro, M. Dezotti, J.P. Bassin, M.E. Quinta-Ferreira, R.M. Quinta-Ferreira
Publikováno v:
Energy Reports, Vol 6, Iss , Pp 903-908 (2020)
Some organic recalcitrant compounds are not degraded by conventional water treatment systems, making necessary the use of advanced technologies to eliminate these substances. Advanced Oxidation Processes (AOPs) have been extensively proposed to remov
Externí odkaz:
https://doaj.org/article/df4c186ca11447258af003c178b66410