Zobrazeno 1 - 10
of 115
pro vyhledávání: '"M, Bertholet"'
Autor:
Ching-Fang Chang, Amanda L. Gunawan, Irene Liparulo, Peter-James H. Zushin, Ambre M. Bertholet, Yuriy Kirichok, Andreas Stahl
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 14 (2022)
Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditar
Externí odkaz:
https://doaj.org/article/546b5b22ef0145478982fd66a7669bbb
Autor:
Ambre M. Bertholet, Yuriy Kirichok
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Mitochondria convert the chemical energy of metabolic substrates into adenosine triphosphate (ATP) and heat. Although ATP production has become a focal point of research in bioenergetics, mitochondrial thermogenesis is also crucial for energy metabol
Externí odkaz:
https://doaj.org/article/0ba6fc5e6c694275ac357d66181890b6
Autor:
Yuriy Kirichok, Ambre M. Bertholet
Publikováno v:
Annu Rev Physiol
Mitochondria of all tissues convert various metabolic substrates into two forms of energy: ATP and heat. Historically, the primary focus of research in mitochondrial bioenergetics was on the mechanisms of ATP production, while mitochondrial thermogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b450eba69524aa8ee38ddd24bbe605b
https://doi.org/10.1146/annurev-physiol-021119-034405
https://doi.org/10.1146/annurev-physiol-021119-034405
Autor:
Will M. Skinner, Natalie T. Petersen, Bret Unger, Shaogeng Tang, Emiliano Tabarsi, Julianna Lamm, Liza Jalalian, James Smith, Ambre M. Bertholet, Ke Xu, Yuriy Kirichok, Polina V. Lishko
Sperm motility is necessary for successful fertilization, but there remains controversy about whether human sperm motility is primarily powered by glycolysis or oxidative phosphorylation. To evaluate the plausibility of reducing human sperm mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58cd0519ee93278556564dcffb9c846d
https://doi.org/10.1101/2022.08.04.502752
https://doi.org/10.1101/2022.08.04.502752
Autor:
Ambre M. Bertholet, Andrew M. Natale, Paola Bisignano, Junji Suzuki, Andriy Fedorenko, James Hamilton, Tatiana Brustovetsky, Lawrence Kazak, Ryan Garrity, Edward T. Chouchani, Nickolay Brustovetsky, Michael Grabe, Yuriy Kirichok
Publikováno v:
Nature, vol 606, iss 7912
Nature
Nature
Mitochondria generate heat due to H(+) leak (I(H)) across their inner membrane(1). I(H) results from the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat(2-6) and ADP/ATP carrier (AAC) in other tissues(1,7-9), but the unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faeff253dcb77787812b31eb037c768
https://escholarship.org/uc/item/98k9g6kh
https://escholarship.org/uc/item/98k9g6kh
Autor:
Ching-Fang Chang, Amanda L. Gunawan, Peter-James H. Zushin, Greg A. Timblin, Ambre M. Bertholet, Biao Wang, Kaoru Sajio, Yuriy Kirichok, Andreas Stahl
Coenzyme Q (CoQ) is an essential component of mitochondrial respiration1 and required for thermogenic activity in brown adipose tissues2 (BAT). CoQ deficiency leads to a wide range of pathological manifestations3 but mechanistic consequences of CoQ d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7db09754882b03e5c9a800ecc7a34f17
https://doi.org/10.1101/2022.03.18.484957
https://doi.org/10.1101/2022.03.18.484957
Autor:
V.A. Berger, C. Jubé, A. Forestier, C. Mitonneau, H. Humeau, S. Limouzin, M. Tiercin, L. Morlière, L. Geoffrois, M. Cabart, M. Bertholet, C. Llambrich-Molines, S. Breysse, S. Laghouati, N. Beaumont
Publikováno v:
Annals of Oncology. 33:S1285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e191a2ba3c549ac8b16a7d6310d2174d
https://doi.org/10.1016/j.annonc.2022.07.1930
https://doi.org/10.1016/j.annonc.2022.07.1930
Autor:
Ambre M. Bertholet
Publikováno v:
Journal of visualized experiments : JoVE. (171)
Mitochondrial thermogenesis (also known as mitochondrial uncoupling) is one of the most promising targets for increasing energy expenditure to combat metabolic syndrome. Thermogenic tissues such as brown and beige fats develop highly specialized mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1306b2b25a1b200a51f2976bc0a378d0
https://pubmed.ncbi.nlm.nih.gov/33999016
https://pubmed.ncbi.nlm.nih.gov/33999016
Autor:
Esther Paulo, Catherine E. Gleason, Yixuan Wu, Ajay Chawla, Seunghwan Lee, Biao Wang, David A. Pearce, Prasanna K.R. Allu, Gavin Situ, Ambre M. Bertholet, Bidisha Saha
Publikováno v:
The Journal of Biological Chemistry
Nonshivering thermogenesis is essential for mammals to maintain body temperature. According to the canonical view, temperature is sensed by cutaneous thermoreceptors and nerve impulses transmitted to the hypothalamus, which generates sympathetic sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf5e598fa616663a0fba4245500757e
http://europepmc.org/articles/PMC8121962
http://europepmc.org/articles/PMC8121962
Autor:
Yuriy Kirichok, Ambre M. Bertholet
Publikováno v:
Biochimie. 134:28-34
Adaptive thermogenesis regulates core body temperature, controls fat deposition, and contributes strongly to the overall energy balance. This process occurs in brown fat and requires uncoupling protein 1 (UCP1), an integral protein of the inner mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40cf16c4fab6d8422fa4ea19c3f3fb79
https://doi.org/10.1016/j.biochi.2016.10.013
https://doi.org/10.1016/j.biochi.2016.10.013