Zobrazeno 1 - 10
of 170
pro vyhledávání: '"M, Balazy"'
Publikováno v:
Journal of Biological Chemistry. 266:6726-6730
Previous work has shown that, shortly after rabbit corneas are injured, arachidonic acid metabolism is activated, and 12-hydroxyeicosatetraenoic acid (12-HETE) is one of the main products formed (Bazan, H. E. P., Birkle, D. L., Beuerman, R., and Baza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03f8084a05db8462f3ade86550a5f66
https://doi.org/10.1016/s0021-9258(20)89559-3
https://doi.org/10.1016/s0021-9258(20)89559-3
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Nitric oxide (NO)-derived species could potentially react with arachidonic acid to generate novel vasoactive metabolites. We studied the reaction of arachidonic acid with nitrogen dioxide (NO2), a free radical that originates from NO oxidation. The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd0ce1f46ebce2dac71ba7d23a005e5f
https://pubmed.ncbi.nlm.nih.gov/11602673
https://pubmed.ncbi.nlm.nih.gov/11602673
Autor:
M, Balazy
Publikováno v:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 51(4 Pt 1)
Inflammation and many other pathological processes lead to increased production of free radicals that target critical macromolecules such as proteins, DNA and lipids. Structural modifications of these molecules, induced by free radicals, typically re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7c0570f8496dcbaf4d9c871cff60aaf
https://pubmed.ncbi.nlm.nih.gov/11192934
https://pubmed.ncbi.nlm.nih.gov/11192934
Autor:
M M, Bednar, C E, Gross, S R, Russell, S P, Fuller, T P, Ahern, D B, Howard, J R, Falck, K M, Reddy, M, Balazy
Publikováno v:
Neurosurgery. 47(6)
Activated polymorphonuclear leukocytes (PMNs) have been suggested to contribute to the development of increased intracranial pressure (ICP). We recently demonstrated that human PMNs produce a novel cytochrome P450-derived arachidonic acid metabolite,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00a44356023de7fe89cfd7ac32c52425
https://pubmed.ncbi.nlm.nih.gov/11126912
https://pubmed.ncbi.nlm.nih.gov/11126912
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(1)
Peroxynitrite (ONOO(-)), a reactive oxidant produced by the reaction between nitric oxide and superoxide, was found to diffuse into the platelet cytosol and inhibit arachidonic acid-induced platelet aggregations with IC(50) value of 5.8 +/- 1.2 micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5d6c06b3b55019a0a758fa5e390df6e
https://pubmed.ncbi.nlm.nih.gov/10734173
https://pubmed.ncbi.nlm.nih.gov/10734173
Publikováno v:
The Journal of biological chemistry. 274(23)
Oxygen free radicals oxidize arachidonic acid to a complex mixture of metabolites termed isoeicosanoids that share structural similarity to enzymatically derived eicosanoids. However, little is known about oxidations of arachidonic acid mediated by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b377dc8e186ea270c4b8bc725a5175e4
https://pubmed.ncbi.nlm.nih.gov/10347179
https://pubmed.ncbi.nlm.nih.gov/10347179
Publikováno v:
Advances in experimental medicine and biology. 433
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5b83ec0bdb6335a3cc47fb3c1e4f2f3
https://pubmed.ncbi.nlm.nih.gov/9561103
https://pubmed.ncbi.nlm.nih.gov/9561103
Publikováno v:
Scopus-Elsevier
The cytochrome P450 system transforms AA to hydroxyeicosatetraenoic acid (HETE) metabolites that are vasoactive and affect transport in several nephron segments. A principal product of this system, 20-HETE, participates in key mechanisms that regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49af69422e11129f38dcccc0a900ec9e
http://hdl.handle.net/11577/2460108
http://hdl.handle.net/11577/2460108
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(6)
The regioselective epoxidation of oleic, linoleic, alpha-linolenic, and gamma-linolenic acid by cytochromes P4502CAA and P4502C2 was characterized. Epoxide metabolites for all fatty acids were resolved by normal phase HPLC and identified by gas chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c61e288e0d516b9b7b5b5ecb799e32aa
https://pubmed.ncbi.nlm.nih.gov/8781783
https://pubmed.ncbi.nlm.nih.gov/8781783
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
5,6-Epoxyeicosatrienoic acid (5,6-EET), a cytochrome P450-dependent arachidonate product, is a substrate for cyclooxygenase (COX) and, in some vascular preparations, elicits COX-dependent vasodilation. In the blood perfused rat kidney, 5,6-EET causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b2bd864e862a54472077375b32bc103
https://pubmed.ncbi.nlm.nih.gov/8667178
https://pubmed.ncbi.nlm.nih.gov/8667178