Cosmogenic background simulations for neutrinoless double beta decay with the DARWIN observatory at various underground sites

Autor: DARWIN Collaboration, M. Adrover, L. Althueser, B. Andrieu, E. Angelino, J. R. Angevaare, B. Antunovic, E. Aprile, M. Babicz, D. Bajpai, E. Barberio, L. Baudis, M. Bazyk, N. Bell, L. Bellagamba, R. Biondi, Y. Biondi, A. Bismark, C. Boehm, A. Breskin, E. J. Brookes, A. Brown, G. Bruno, R. Budnik, C. Capelli, J. M. R. Cardoso, A. Chauvin, A. P. Cimental Chavez, A. P. Colijn, J. Conrad, J. J. Cuenca-García, V. D’Andrea, M. P. Decowski, A. Deisting, P. Di Gangi, S. Diglio, M. Doerenkamp, G. Drexlin, K. Eitel, A. Elykov, R. Engel, S. Farrell, A. D. Ferella, C. Ferrari, H. Fischer, M. Flierman, W. Fulgione, P. Gaemers, R. Gaior, M. Galloway, N. Garroum, S. Ghosh, F. Girard, R. Glade-Beucke, F. Glück, L. Grandi, J. Grigat, R. Größle, H. Guan, M. Guida, R. Hammann, V. Hannen, S. Hansmann-Menzemer, N. Hargittai, T. Hasegawa, C. Hils, A. Higuera, K. Hiraoka, L. Hoetzsch, M. Iacovacci, Y. Itow, J. Jakob, F. Jörg, M. Kara, P. Kavrigin, S. Kazama, M. Keller, B. Kilminster, M. Kleifges, M. Kobayashi, A. Kopec, B. von Krosigk, F. Kuger, H. Landsman, R. F. Lang, I. Li, S. Li, S. Liang, S. Lindemann, M. Lindner, F. Lombardi, J. Loizeau, T. Luce, Y. Ma, C. Macolino, J. Mahlstedt, A. Mancuso, T. Marrodán Undagoitia, J. A. M. Lopes, F. Marignetti, K. Martens, J. Masbou, S. Mastroianni, S. Milutinovic, K. Miuchi, R. Miyata, A. Molinario, C. M. B. Monteiro, K. Morå, E. Morteau, Y. Mosbacher, J. Müller, M. Murra, J. L. Newstead, K. Ni, U. G. Oberlack, I. Ostrovskiy, B. Paetsch, M. Pandurovic, Q. Pellegrini, R. Peres, J. Pienaar, M. Pierre, M. Piotter, G. Plante, T. R. Pollmann, L. Principe, J. Qi, J. Qin, M. Rajado Silva, D. Ramírez García, A. Razeto, S. Sakamoto, L. Sanchez, P. Sanchez-Lucas, J. M. F. dos Santos, G. Sartorelli, A. Scaffidi, P. Schulte, H.-C. Schultz-Coulon, H. Schulze Eißing, M. Schumann, L. Scotto Lavina, M. Selvi, F. Semeria, P. Shagin, S. Sharma, W. Shen, M. Silva, H. Simgen, R. Singh, M. Solmaz, O. Stanley, M. Steidl, P.-L. Tan, A. Terliuk, D. Thers, T. Thümmler, F. Tönnies, F. Toschi, G. Trinchero, R. Trotta, C. Tunnell, P. Urquijo, K. Valerius, S. Vecchi, S. Vetter, G. Volta, D. Vorkapic, W. Wang, K. M. Weerman, C. Weinheimer, M. Weiss, D. Wenz, C. Wittweg, J. Wolf, T. Wolf, V. H. S. Wu, M. Wurm, Y. Xing, M. Yamashita, J. Ye, G. Zavattini, K. Zuber

Publikováno v: European Physical Journal C: Particles and Fields, Vol 84, Iss 1, Pp 1-14 (2024)

Abstract Xenon dual-phase time projections chambers (TPCs) have proven to be a successful technology in studying physical phenomena that require low-background conditions. With $$40\,\textrm{t}$$ 40 t of liquid xenon (LXe) in the TPC baseline design,

Externí odkaz: https://doaj.org/article/85cbbcd83d504c7a802d9975262660df

Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection

Autor: Jose M. Adrover, Lucia Carrau, Juliane Daßler-Plenker, Yaron Bram, Vasuretha Chandar, Sean Houghton, David Redmond, Joseph R. Merrill, Margaret Shevik, Benjamin R. tenOever, Scott K. Lyons, Robert E. Schwartz, Mikala Egeblad

Publikováno v: JCI Insight, Vol 7, Iss 5 (2022)

Severe acute lung injury has few treatment options and a high mortality rate. Upon injury, neutrophils infiltrate the lungs and form neutrophil extracellular traps (NETs), damaging the lungs and driving an exacerbated immune response. Unfortunately,

Externí odkaz: https://doaj.org/article/12ddc5fdf3f044f9b0d26f8c3e6fe90c

Circadian Features of Neutrophil Biology

Autor: Alejandra Aroca-Crevillén, José M. Adrover, Andrés Hidalgo

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Rhythms in immunity manifest in multiple ways, but perhaps most prominently by the recurrent onset of inflammation at specific times of day. These patterns are of importance to understand human disease and are caused, in many instances, by the action

Externí odkaz: https://doaj.org/article/c0a0b0fe7a7a4f1d88d77f687f344ac4

Data from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

Autor: Scott W. Lowe, Direna Alonso-Curbelo, Zhenghao Chen, Mikala Egeblad, Ronald C. Hendrickson, Caroline Broderick, Xiang Li, Sha Tian, Alexandra Wuest, Wei Luan, Linda Fong, Georgia Schmitt, Nicholas Bernstein, Katharina Woess, Changyu Zhu, Ryan Smolkin, Jose M. Adrover, Riccardo Mezzadra, Yu-Jui Ho, Hsuan-An Chen

Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune-competent liver cancer model in which senescence triggers CD8 T cell�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460aeb93387f41a0abbf2c6e4b2074ee
https://doi.org/10.1158/2159-8290.c.6549996

Supplementary Table S3 from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

Autor: Scott W. Lowe, Direna Alonso-Curbelo, Zhenghao Chen, Mikala Egeblad, Ronald C. Hendrickson, Caroline Broderick, Xiang Li, Sha Tian, Alexandra Wuest, Wei Luan, Linda Fong, Georgia Schmitt, Nicholas Bernstein, Katharina Woess, Changyu Zhu, Ryan Smolkin, Jose M. Adrover, Riccardo Mezzadra, Yu-Jui Ho, Hsuan-An Chen

Low (50 pg/ml) and high (1 ng/ml) dose of IFN-γ treatment in proliferating and senescent NSP cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e234cdc12b05ad25cca33d3d8566c28
https://doi.org/10.1158/2159-8290.22542627.v1