Zobrazeno 1 - 10
of 157
pro vyhledávání: '"M, Absher"'
Autor:
Peter C. Allen, Sarah Smith, Robert C. Wilson, Jena R. Wirth, Nathan H. Wilson, DeAnna Baker Frost, Jonathan Flume, Gary S. Gilkeson, Melissa A. Cunningham, Carl D. Langefeld, Devin M. Absher, Paula S. Ramos
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Systemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African Americans. Despite this, African Americans are dramatically underrepresented in SSc resear
Externí odkaz:
https://doaj.org/article/9bde2b02efb54851af0a150dc4de6d0c
Autor:
Alana C. Jones, Zsuzsanna Ament, Amit Patki, Ninad S. Chaudhary, Vinodh Srinivasasainagendra, Naruchorn Kijpaisalratana, Devin M. Absher, Hemant K. Tiwari, Donna K. Arnett, W. Taylor Kimberly, Marguerite R. Irvin
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Metabolic syndrome (MetS) increases the risk of cardiovascular disease and death. Previous ‘-omics’ studies have identified dysregulated serum metabolites and aberrant DNA methylation in the setting of MetS. However, the relationshi
Externí odkaz:
https://doaj.org/article/cdf1fb13f92140d99be9599ae81e8a94
Autor:
Tina Roostaei, Hans-Ulrich Klein, Yiyi Ma, Daniel Felsky, Pia Kivisäkk, Sarah M. Connor, Alexandra Kroshilina, Christina Yung, Belinda J. Kaskow, Xiaorong Shao, Brooke Rhead, José M. Ordovás, Devin M. Absher, Donna K. Arnett, Jia Liu, Nikolaos Patsopoulos, Lisa F. Barcellos, Howard L. Weiner, Philip L. De Jager
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Integrating functional data with GWAS loci can help interpret the function of genetic variants associated with disease. Here the authors map cis and trans methylation QTL in CD4 + T cells from patients and colocalize with GWAS loci in order to interp
Externí odkaz:
https://doaj.org/article/291325cdf14d4e2c98f8c4f10488c6f4
Autor:
Mina-A Jhun, Michael Mendelson, Rory Wilson, Rahul Gondalia, Roby Joehanes, Elias Salfati, Xiaoping Zhao, Kim Valeska Emilie Braun, Anh Nguyet Do, Åsa K. Hedman, Tao Zhang, Elena Carnero-Montoro, Jincheng Shen, Traci M. Bartz, Jennifer A. Brody, May E. Montasser, Jeff R. O’Connell, Chen Yao, Rui Xia, Eric Boerwinkle, Megan Grove, Weihua Guan, Pfeiffer Liliane, Paula Singmann, Martina Müller-Nurasyid, Thomas Meitinger, Christian Gieger, Annette Peters, Wei Zhao, Erin B. Ware, Jennifer A. Smith, Klodian Dhana, Joyce van Meurs, Andre Uitterlinden, Mohammad Arfan Ikram, Mohsen Ghanbari, Deugi Zhi, Stefan Gustafsson, Lars Lind, Shengxu Li, Dianjianyi Sun, Tim D. Spector, Yii-der Ida Chen, Coleen Damcott, Alan R. Shuldiner, Devin M. Absher, Steve Horvath, Philip S. Tsao, Sharon Kardia, Bruce M. Psaty, Nona Sotoodehnia, Jordana T. Bell, Erik Ingelsson, Wei Chen, Abbas Dehghan, Donna K. Arnett, Melanie Waldenberger, Lifang Hou, Eric A. Whitsel, Andrea Baccarelli, Daniel Levy, Myriam Fornage, Marguerite R. Irvin, Themistocles L. Assimes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify
Externí odkaz:
https://doaj.org/article/5a34ff34ea7042f0b1ef2141f1a26dde
Autor:
Antonio Julià, Antonio Gómez, María López-Lasanta, Francisco Blanco, Alba Erra, Antonio Fernández-Nebro, Antonio Juan Mas, Carolina Pérez-García, Ma Luz García Vivar, Simón Sánchez-Fernández, Mercedes Alperi-López, Raimon Sanmartí, Ana María Ortiz, Carlos Marras Fernandez-Cid, César Díaz-Torné, Estefania Moreno, Tianlu Li, Sergio H. Martínez-Mateu, Devin M. Absher, Richard M. Myers, Jesús Tornero Molina, Sara Marsal
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104053- (2022)
Summary: Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation that is
Externí odkaz:
https://doaj.org/article/c01aa2013efd41f0b681b63c0066adb7
Publikováno v:
eLife, Vol 11 (2022)
Mapping of allelic imbalance (AI) at heterozygous loci has the potential to establish links between genetic risk for disease and biological function. Leveraging multi-omics data for AI analysis and functional annotation, we discovered a novel functio
Externí odkaz:
https://doaj.org/article/c87363e1ad494379b06a2b617618c18d
Publikováno v:
BMC Proceedings, Vol 12, Iss S9, Pp 5-10 (2018)
Abstract GAW20 provided participants with an opportunity to comprehensively examine genetic and epigenetic variation among related individuals in the context of drug treatment response. GAW20 used data from 188 families (N = 1105) participating in th
Externí odkaz:
https://doaj.org/article/73370670bd7b4b159967e4a50ca741c7
Autor:
Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher, Donna K. Arnett
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background Recently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities. However, accelerated epigenetic aging has not been widely in
Externí odkaz:
https://doaj.org/article/4b653b4689f74e7188aaaec48dd33048
Autor:
Min-A Jhun, Michael Mendelson, Rory Wilson, Rahul Gondalia, Roby Joehanes, Elias Salfati, Xiaoping Zhao, Kim Valeska Emilie Braun, Anh Nguyet Do, Åsa K. Hedman, Tao Zhang, Elena Carnero-Montoro, Jincheng Shen, Traci M. Bartz, Jennifer A. Brody, May E. Montasser, Jeff R. O’Connell, Chen Yao, Rui Xia, Eric Boerwinkle, Megan Grove, Weihua Guan, Pfeiffer Liliane, Paula Singmann, Martina Müller-Nurasyid, Thomas Meitinger, Christian Gieger, Annette Peters, Wei Zhao, Erin B. Ware, Jennifer A. Smith, Klodian Dhana, Joyce van Meurs, Andre Uitterlinden, Mohammad Arfan Ikram, Mohsen Ghanbari, Deugi Zhi, Stefan Gustafsson, Lars Lind, Shengxu Li, Dianjianyi Sun, Tim D. Spector, Yii-der Ida Chen, Coleen Damcott, Alan R. Shuldiner, Devin M. Absher, Steve Horvath, Philip S. Tsao, Sharon Kardia, Bruce M. Psaty, Nona Sotoodehnia, Jordana T. Bell, Erik Ingelsson, Wei Chen, Abbas Dehghan, Donna K. Arnett, Melanie Waldenberger, Lifang Hou, Eric A. Whitsel, Andrea Baccarelli, Daniel Levy, Myriam Fornage, Marguerite R. Irvin, Themistocles L. Assimes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/c5539a98f98545febc3cd60237d50331
Autor:
Nicholas D. Johnson, Howard W. Wiener, Alicia K. Smith, Shota Nishitani, Devin M. Absher, Donna K. Arnett, Stella Aslibekyan, Karen N. Conneely
Publikováno v:
Epigenetics, Vol 12, Iss 6, Pp 492-503 (2017)
DNA methylation (DNAm) is an important epigenetic process involved in the regulation of gene expression. While many studies have identified thousands of loci associated with age, few have differentiated between linear and non-linear DNAm trends with
Externí odkaz:
https://doaj.org/article/a2bd9db6131646adbe5e4a9ee6efc288