Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Lyudmila G. Burdelya"'
Autor:
Craig M. Brackett, Kellee F. Greene, Alyssa R. Aldrich, Nicholas H. Trageser, Srabani Pal, Ivan Molodtsov, Bojidar M. Kandar, Lyudmila G. Burdelya, Scott I. Abrams, Andrei V. Gudkov
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as
Externí odkaz:
https://doaj.org/article/b4c8b20a57ee4a1e98fe58a3cedda4f2
Autor:
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent
Externí odkaz:
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
Autor:
Ashish Bhattacharjee, Narayan Chandra Mandal, Naibedya Dutta, Andrei V. Gudkov, Lyudmila G. Burdelya, Gopal C. Kundu, Pinaki Banerjee, Srabani Pal, V. Ravichandiran, Mahadeb Pal, Hossainoor Rahaman Sareng, Suvranil Ghosh, Prachi Kapse, Rahul L. Gajbhiye
Publikováno v:
Free Radical Biology and Medicine. 172:136-151
Prostate cancer (PCa) is a major cause of mortality and morbidity in men. Available therapies yield limited outcome. We explored anti-PCa activity in a polyphenol-rich fraction of Bergenia ligulata (PFBL), a plant used in Indian traditional and folk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd39b9397efb0f3b17b1fcab4cbf0da
https://doi.org/10.1016/j.freeradbiomed.2021.05.037
https://doi.org/10.1016/j.freeradbiomed.2021.05.037
Autor:
Craig M. Brackett, Catherine Burkhart, Ilia Toshkov, Andrei L. Osterman, Ivan A. Bespalov, Andrei Purmal, Vadim L. Mett, Andrei V. Gudkov, Lyudmila G. Burdelya, Yakov N. Kogan, Anatoli S. Gleiberman, Ekaterina L. Andrianova, Ivan Molodtsov, Oleg V. Kurnasov
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including radioprotection and cancer immunotherapy. However, in Phase 1 human studies, entolimod induced a rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdef2dd5c9aac4df928eea9fe09e4c96
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
Autor:
Lyudmila G. Burdelya, Craig M. Brackett, Kellee F. Greene, Alyssa R Aldrich, Andrei V. Gudkov, Scott I. Abrams, Nicholas H Trageser, Ivan Molodtsov, Srabani Pal, Bojidar M. Kandar
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as a prophyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4b142784726a4dfddc9744b6fcd7c2
https://pubmed.ncbi.nlm.nih.gov/34584068
https://pubmed.ncbi.nlm.nih.gov/34584068
Autor:
Nicholas D Leigh, Guanglin Bian, Xilai Ding, Hong Liu, Semra Aygun-Sunar, Lyudmila G Burdelya, Andrei V Gudkov, Xuefang Cao
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85587 (2014)
Toll-like receptor (TLR) mediated recognition of pathogen associated molecular patterns allows the immune system to rapidly respond to a pathogenic insult. The "danger context" elicited by TLR agonists allows an initially non-immunogenic antigen to b
Externí odkaz:
https://doaj.org/article/270d871306254ada996b5160ec752653
Autor:
Santosh K. Patnaik, Katerina Gurova, Andrei V. Gudkov, Junko Matsuzaki, Elizabeth A. Repasky, Craig M. Brackett, Lyudmila G. Burdelya, Adekunle Odunsi, Achamaporn Punnanitinont, Anurag K. Singh, Minhui Chen
Publikováno v:
Cancer Immunol Immunother
Curaxins are small molecules that bind genomic DNA and interfere with DNA-histone interactions leading to the loss of histones and decondensation of chromatin. We named this phenomenon ‘chromatin damage’. Curaxins demonstrated anti-cancer activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856e6168a6e651b14d8d273e711ad5b4
https://pubmed.ncbi.nlm.nih.gov/33439292
https://pubmed.ncbi.nlm.nih.gov/33439292
Autor:
Craig M Brackett, Alyssa R Aldrich, Kellee F Greene, Bojidar Kandar, Jean Veith, Lyudmila G Burdelya, Scott I. Abrams, Andrei V Gudkov
Publikováno v:
Cancer Research. 82:P4-04
Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancer diagnoses, is the most aggressive form of the disease, and has the poorest clinical outcomes. Effective or durable therapies are lacking because these tumors lack targets f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9da0f0fc4ffd7347aebd50887b921745
https://doi.org/10.1158/1538-7445.sabcs21-p4-04-02
https://doi.org/10.1158/1538-7445.sabcs21-p4-04-02
Autor:
Hans E. Grossniklaus, Craig M. Brackett, Vanessa M. Morales-Tirado, Edmund K. Waller, Qing Zhang, Wayne Harris, Lyudmila G. Burdelya, Matthew W. Wilson, Camille A Benjamin, Zezhong Li, Andrei V. Gudkov, Hua Yang
Publikováno v:
Oncotarget
Uveal melanoma (UM) is the most common primary cancer of the eye in adults and progresses to metastatic disease predominantly of the liver in ∼50% of patients. In these cases, life expectancy averages just 9 months due to the lack of effective trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9a4f05b7e2e64dd3d4264dd28a07fa
https://doi.org/10.18632/oncotarget.6500
https://doi.org/10.18632/oncotarget.6500
Autor:
Geraldine M. Paszkiewicz, Andrei V. Gudkov, Venkatesh Natarajan, Craig M. Brackett, Gary Haderski, Ilia M. Toshkov, Christopher Johnson, Bojidar M. Kandar, Lyudmila G. Burdelya, Anatoli S. Gleiberman
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0227940 (2020)
PLoS ONE
PLoS ONE
Tumor necrosis factor alpha (TNF) is capable of inducing regression of solid tumors. However, TNF released in response to Toll-like receptor 4 (TLR4) activation by bacterial lipopolysaccharide (LPS) is the key mediator of cytokine storm and septic sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a390265430f4f724df551b5642f75b
https://doi.org/10.1371/journal.pone.0227940
https://doi.org/10.1371/journal.pone.0227940