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Design of Tetrapeptides as a Competitive Inhibitor for HMG-CoA Reductase and Modeling Recognized Sequence as a β-Turn Structure

Autor: Valeriy V. Pak, Olim K. Khojimatov, Aleksandr V. Pak, Shomansur Sh. Sagdullaev, Lyubov Yun

Publikováno v: International Journal of Peptide Research and Therapeutics. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7171c346640c66582a579dcec6b5e46
https://doi.org/10.1007/s10989-022-10455-5

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Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG‐CoA reductase

Autor: Lyubov Yun, Hye Jeong Yang, Valeriy V. Pak, Minseon Koo, Dae Young Kwon, Min Jung Kim

Publikováno v: Journal of Molecular Recognition. 21:224-232

This study presents an approach that can be used to search for lead peptide candidates, including unconstrained structures in a recognized sequence. This approach was performed using the design of a competitive inhibitor for 3-hydroxy-3-methylglutary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdc327ba86ca6263cf829cf933817b7
https://doi.org/10.1002/jmr.889

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Recognized sequence and conformation in design of linear peptides as a competitive inhibitor for HMG-CoA reductase

Autor: Lyubov Yun, Valeriy V. Pak, Dae Young Kwon, Minseon Koo

Publikováno v: Journal of Molecular Recognition. 20:197-203

This study is an attempt to develop a simple search method for lead peptide candidates, which include constrained structures in a recognized sequence, using the design of a competitive inhibitor for HMG-CoA reductase (HMGR). A structure-functional an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad33052ca9f82db1d8940a168256a14
https://doi.org/10.1002/jmr.824

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Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase

Autor: Valeriy V. Pak, Lyubov Yun, Dae Young Kwon, Minseon Koo

Publikováno v: Amino acids. 43(5)

This study presents a design of a highly potent and competitive inhibitory peptide for 3-hydroxy-3-methylglutaryl CoA reductase (HMGR). HMGR is the major regulatory enzyme of cholesterol biosynthesis and the target enzyme of many investigations aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091000a4eaaaec04af253f1b12f32b83
https://pubmed.ncbi.nlm.nih.gov/22451276

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Modeling an Active Peptide Conformation and Design a Competitive Inhibitory Peptide for HMG-CoA Reductase

Autor: Vladimir N. Shin, Valeriy V. Pak, Lyubov Yun

Publikováno v: Springer Proceedings in Physics ISBN: 9783642179129

The current work presents an approach that can be used to search for lead peptide candidates, including unconstrained structures in a recognized sequence. This approach was performed using the design of a competitive inhibitor for HMG-CoA reductase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc4978b3d2d74141880c93d1b657b63b
https://doi.org/10.1007/978-3-642-17913-6_16

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Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase

Autor: Dae Young Kwon, Minseon Koo, Lyubov Yun, Khusnutdin M. Shakhidoyatov, Valeriy V. Pak

Publikováno v: Bioorganicmedicinal chemistry. 18(12)

This study presents a simple method to design an active peptide based on a description of the structural preferences of peptide via its peptide fragments. In a previous design, while searching for lead peptide candidates, the efficacy of a design app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38661e807f07a48908b2e59bc99633ce
https://pubmed.ncbi.nlm.nih.gov/20494585

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