Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lyubomir Dimitrov Stanchev"'
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The transportome of Saccharomyces cerevisiae comprises approximately 340 membrane-bound proteins, of which very few are well-characterized. Elucidating transporter proteins’ function is essential not only for understanding central cellular processe
Externí odkaz:
https://doaj.org/article/182242d9069a448ea6be6b205ece8422
Autor:
Juliana Rizzo, Lyubomir Dimitrov Stanchev, Vanessa K.A. da Silva, Leonardo Nimrichter, Thomas Günther Pomorski, Marcio L. Rodrigues
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1278-1289 (2019)
The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been rece
Externí odkaz:
https://doaj.org/article/a2118fb91e614512888227e437dba283
Autor:
Lyubomir Dimitrov Stanchev, Juliana Rizzo, Rebecca Peschel, Lilli A. Pazurek, Lasse Bredegaard, Sarina Veit, Sabine Laerbusch, Marcio L. Rodrigues, Rosa L. López-Marqués, Thomas Günther Pomorski
Publikováno v:
Journal of Fungi, Vol 7, Iss 10, p 843 (2021)
Lipid flippases of the P4-ATPase family are ATP-driven transporters that translocate lipids from the exoplasmic to the cytosolic leaflet of biological membranes. In the encapsulated fungal pathogen Cryptococcus neoformans, the P4-ATPase Apt1p is an i
Externí odkaz:
https://doaj.org/article/5d6bcff620d549f287656bfe50c80614
Autor:
Lyubomir Dimitrov Stanchev, Magdalena Marek, Feng Xian, Mara Klöhn, Daniele Silvestro, Gunnar Dittmar, Rosa Laura López-Marqués, Thomas Günther Pomorski
Publikováno v:
Journal of Fungi, Vol 7, Iss 1, p 2 (2020)
The pleiotropic drug resistance (PDR) transporter Pdr11p is expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae, where it facilitates the uptake of exogenous sterols. Members of the fungal PDR fami
Externí odkaz:
https://doaj.org/article/1ae2e64e663e4456bae764155549a101
Autor:
Katrine Rude Laub, Magdalena Marek, Lyubomir Dimitrov Stanchev, Sara Abad Herrera, Tamara Kanashova, Adèle Bourmaud, Gunnar Dittmar, Thomas Günther Pomorski
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184236 (2017)
The ATP binding cassette (ABC) transporters Pdr11p and its paralog Aus1p are expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae and are required for sterol uptake. However, the precise mechanism b
Externí odkaz:
https://doaj.org/article/e5215dc6bf7040e284cf948303dcf867
Autor:
Steven A. van der Hoek, Matej Rusnák, Guokun Wang, Lyubomir Dimitrov Stanchev, Luana de Fátima Alves, Mathew M. Jessop-Fabre, Kalaivani Paramasivan, Irene Hjorth Jacobsen, Nikolaus Sonnenschein, José L. Martínez, Behrooz Darbani, Douglas B. Kell, Irina Borodina
Publikováno v:
Steven A.van derHoek, Matej Rusnák, Guokun Wang, Lyubomir Dimitrov Stanchev, Luana de Fátima Alves, Mathew M.Jessop-Fabre, Kalaivani Paramasivan, Irene Hjorth Jacobsen, Nikolaus Sonnenschein, José L.Martínez,, Darbani, B, Douglas B.Kell & Irina Borodina 2022, ' Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae ', Metabolic Engineering, vol. 70, pp. 129-142 . https://doi.org/10.1016/j.ymben.2022.01.012
Hoek, S A V D, Rusnák, M, Wang, G, Stanchev, L D, de Fátima Alves, L, Jessop-Fabre, M M, Paramasivan, K, Jacobsen, I H, Sonnenschein, N, Martínez, J L, Darbani, B, Kell, D B & Borodina, I 2022, ' Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae ', Metabolic Engineering, vol. 70, pp. 129-142 . https://doi.org/10.1016/j.ymben.2022.01.012
Hoek, S A V D, Rusnák, M, Wang, G, Stanchev, L D, de Fátima Alves, L, Jessop-Fabre, M M, Paramasivan, K, Jacobsen, I H, Sonnenschein, N, Martínez, J L, Darbani, B, Kell, D B & Borodina, I 2022, ' Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae ', Metabolic Engineering, vol. 70, pp. 129-142 . https://doi.org/10.1016/j.ymben.2022.01.012
Ergothioneine (ERG) is an unusual sulfur-containing amino acid. It is a potent antioxidant, which shows great potential for ameliorating neurodegenerative and cardiovascular diseases. L-ergothioneine is rare in nature, with mushrooms being the primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b0996555c4ed304101547e1315452f
https://pubmed.ncbi.nlm.nih.gov/35085780
https://pubmed.ncbi.nlm.nih.gov/35085780
Autor:
Vanessa Karina Alves da Silva, Marcio L. Rodrigues, Leonardo Nimrichter, Thomas Günther Pomorski, Lyubomir Dimitrov Stanchev, Juliana Rizzo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1278-1289 (2019)
Rizzo, J, Stanchev, L D, da Silva, V K A, Nimrichter, L, Pomorski, T G & Rodrigues, M L 2019, ' Role of lipid transporters in fungal physiology and pathogenicity ', Computational and Structural Biotechnology Journal, vol. 17, pp. 1278-1289 . https://doi.org/10.1016/j.csbj.2019.09.001
Computational and Structural Biotechnology Journal
Rizzo, J, Stanchev, L D, da Silva, V K A, Nimrichter, L, Pomorski, T G & Rodrigues, M L 2019, ' Role of lipid transporters in fungal physiology and pathogenicity ', Computational and Structural Biotechnology Journal, vol. 17, pp. 1278-1289 . https://doi.org/10.1016/j.csbj.2019.09.001
Computational and Structural Biotechnology Journal
The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2d8d9e153a196bb07bd9ea3613a1ca
http://www.sciencedirect.com/science/article/pii/S2001037019302557
http://www.sciencedirect.com/science/article/pii/S2001037019302557
Autor:
Sara Rute Costa, Thomas Günther Pomorski, Helle Juel Martens, Daniele Silvestro, Danny Mollerup Sørensen, Henrik Waldal Holen, Jesper Torbøl Pedersen, Lyubomir Dimitrov Stanchev, Rosa L. López-Marqués, Michael G. Palmgren
Publikováno v:
Molecular Biology of the Cell
Sørensen, D M, Holen, H W, Pedersen, J T, Martens, H J, Silvestro, D, Stanchev, L D, Costa, S R, Pomorski, T G, López-Marqués, R L & Palmgren, M 2019, ' The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis ', Molecular Biology of the Cell, vol. 30, no. 9, pp. 1069-1084 . https://doi.org/10.1091/mbc.E18-06-0365
Sørensen, D M, Holen, H W, Pedersen, J T, Martens, H J, Silvestro, D, Stanchev, L D, Costa, S R, Pomorski, T G, López-Marqués, R L & Palmgren, M 2019, ' The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis ', Molecular Biology of the Cell, vol. 30, no. 9, pp. 1069-1084 . https://doi.org/10.1091/mbc.E18-06-0365
P5A ATPases are expressed in the endoplasmic reticulum (ER) of all eukaryotic cells, and their disruption results in severe ER stress. However, the function of these ubiquitous membrane proteins, which belong to the P-type ATPase superfamily, is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ef4503deeb4360d3f7860fc9a5e1f8
http://europepmc.org/articles/PMC6724510
http://europepmc.org/articles/PMC6724510
Autor:
Linda Sistemich, Thomas Günther Pomorski, Aurélien Roux, Miriam Kutsch, Christian Herrmann, Lyubomir Dimitrov Stanchev
Publikováno v:
The FEBS Journal, Vol. 288, No 13 (2021) pp. 4098-4114
Sistemich, L, Dimitrov Stanchev, L, Kutsch, M, Roux, A, Günther Pomorski, T & Herrmann, C 2021, ' Structural requirements for membrane binding of human guanylate-binding protein 1 ', FEBS Journal, vol. 288, no. 13, pp. 4098-4114 . https://doi.org/10.1111/febs.15703
Sistemich, L, Dimitrov Stanchev, L, Kutsch, M, Roux, A, Günther Pomorski, T & Herrmann, C 2021, ' Structural requirements for membrane binding of human guanylate-binding protein 1 ', FEBS Journal, vol. 288, no. 13, pp. 4098-4114 . https://doi.org/10.1111/febs.15703
Human guanylate-binding protein 1 (hGBP1) is a key player in innate immunity and fights diverse intracellular microbial pathogens. Its antimicrobial functions depend on hGBP1’s GTP binding- and hydrolysis-induced abilities to form large, structured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6016c268736839cbcaec928cd3f7f395
https://archive-ouverte.unige.ch/unige:149956
https://archive-ouverte.unige.ch/unige:149956
Autor:
Mara Klöhn, Feng Xian, Gunnar Dittmar, Daniele Silvestro, Rosa L. López-Marqués, Thomas Günther Pomorski, Lyubomir Dimitrov Stanchev, Magdalena Marek
Publikováno v:
Journal of Fungi
Journal of Fungi, Vol 7, Iss 2, p 2 (2021)
Stanchev, L D, Marek, M, Xian, F, Klöhn, M, Silvestro, D, Dittmar, G, López-Marqués, R L & Günther Pomorski, T 2021, ' Functional Significance of Conserved Cysteines in the Extracellular Loops of the ATP Binding Cassette Transporter Pdr11p ', Journal of Fungi, vol. 7, no. 1, 2 . https://doi.org/10.3390/jof7010002
Volume 7
Issue 1
Journal of Fungi, Vol 7, Iss 2, p 2 (2021)
Stanchev, L D, Marek, M, Xian, F, Klöhn, M, Silvestro, D, Dittmar, G, López-Marqués, R L & Günther Pomorski, T 2021, ' Functional Significance of Conserved Cysteines in the Extracellular Loops of the ATP Binding Cassette Transporter Pdr11p ', Journal of Fungi, vol. 7, no. 1, 2 . https://doi.org/10.3390/jof7010002
Volume 7
Issue 1
The pleiotropic drug resistance (PDR) transporter Pdr11p is expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae, where it facilitates the uptake of exogenous sterols. Members of the fungal PDR fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1109fe71c75b98670f6a31e171914f8b
https://pubmed.ncbi.nlm.nih.gov/33375075
https://pubmed.ncbi.nlm.nih.gov/33375075