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A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampus

Autor: Kambali, Maltesh, Li, Yan, Unichenko, Petr, Pliego, Jessica Feria, Yadav, Rachita, Liu, Jing, McGuinness, Patrick, Cobb, Johanna G., Wang, Muxiao, Nagarajan, Rajasekar, Lyu, Jinrui, Vongsouthi, Vanessa, Jackson, Colin J., Engin, Elif, Coyle, Joseph T., Shin, Jeaweon, Talkowski, Michael E., Homanics, Gregg E., Bolshakov, Vadim Y., Henneberger, Christian, Rudolph, Uwe

Publikováno v: bioRxiv

The biological significance of a small supernumerary marker chromosome that results in dosage alterations to chromosome 9p24.1, including triplication of the GLDC gene encoding glycine decarboxylase, in two patients with psychosis is unclear. In an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb855aa2fc0c431c1058d8c98911e449
https://europepmc.org/articles/PMC10312439/

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Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction.

Autor: Lyu J; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802-6178, USA.; Neuroscience Program, College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802-6178, USA., Nagarajan R; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802-6178, USA., Kambali M; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802-6178, USA., Wang M; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802-6178, USA.; Neuroscience Program, College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802-6178, USA., Rudolph U; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802-6178, USA.; Carl R. Woese Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Publikováno v: PNAS nexus [PNAS Nexus] 2023 Apr 13; Vol. 2 (5), pp. pgad134. Date of Electronic Publication: 2023 Apr 13 (Print Publication: 2023).