Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lyssia Belarif"'
Autor:
Safa Dehmani, Véronique Nerrière-Daguin, Mélanie Néel, Nathan Elain-Duret, Jean-Marie Heslan, Lyssia Belarif, Caroline Mary, Virginie Thepenier, Kevin Biteau, Nicolas Poirier, Gilles Blancho, Fabienne Haspot
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A numerous number of positive and negative signals via various molecules modulate T-cell activation. Within the various transmembrane proteins, SIRPγ is of interest since it is not expressed in rodents. SIRPγ interaction with CD47 is reevaluated in
Externí odkaz:
https://doaj.org/article/e739c9f323054f98b7a63928ad4cb2fa
Autor:
Lyssia Belarif, Caroline Mary, Lola Jacquemont, Hoa Le Mai, Richard Danger, Jeremy Hervouet, David Minault, Virginie Thepenier, Veronique Nerrière-Daguin, Elisabeth Nguyen, Sabrina Pengam, Eric Largy, Arnaud Delobel, Bernard Martinet, Stéphanie Le Bas-Bernardet, Sophie Brouard, Jean-Paul Soulillou, Nicolas Degauque, Gilles Blancho, Bernard Vanhove, Nicolas Poirier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can re
Externí odkaz:
https://doaj.org/article/2f8d89dcfb614001945d31eee5d1a5ce
Publikováno v:
Cell Stress, Vol 2, Iss 12, Pp 362-364 (2018)
Targeting the expansion of pathogenic memory immune cells is a promising therapeutic strategy to prevent chronic autoimmune attacks. Interleukin 7 (IL-7) is a limiting and potent cytokine produced by epithelial and stromal cells sustaining T-lymphocy
Externí odkaz:
https://doaj.org/article/c3138cb56a1d43458e7391bc2b039399
Autor:
Nicolas Poirier, Irène Baccelli, Lyssia Belarif, Riad Abès, Géraldine Teppaz, Caroline Mary, Sonia Poli, Claudia Fromond, Isabelle Girault, Sabrina Pengam, Emilienne Soma, Fanny De Sa, Jean-Pascal Conduzorgues, Cécile Braudeau, Regis Josien, Bram Volckaert, Dominique Costantini, Frédérique Corallo
Publikováno v:
The Journal of Immunology. 210:753-763
OSE-127 is a humanized mAb targeting the IL-7Rα-chain (CD127), under development for inflammatory and autoimmune disease treatment. It is a strict antagonist of the IL-7R pathway, is not internalized by target cells, and is noncytotoxic. In this wor
Autor:
F Corallo, Frédérique Corallo, Irène Baccelli, Lyssia Belarif, Géraldine Teppaz, Mary Caroline, Claudia Fromond, Isabelle Girault, Sabrina Pengam, Emilienne Soma, Fanny De Sa, Jean-Pascal Conduzorgues, Dominique Costantini, Nicolas Poirier
Publikováno v:
Journal of Crohn's and Colitis. 17:i851-i852
Background Key transcripts of the IL-7R pathway were shown to accumulate in inflamed colon tissues of severe IBD patients not responding to conventional or biologics therapies. Furthermore, high expression of both IL7R and IL-7R signaling signature i
Autor:
Thi Van Ha Nguyen, Jeremy Hervouet, Hoa Le Mai, Nicolas Poirier, Jean-Paul Soulillou, David Minault, Julien Branchereau, Gilles Blancho, Caroline Mary, Karine Renaudin, Lyssia Belarif, Sophie Brouard, Bernard Vanhove, Stéphanie Le Bas-Berdardet
Publikováno v:
American Journal of Transplantation
American Journal of Transplantation, 2019, ⟨10.1111/ajt.15543⟩
American Journal of Transplantation, Wiley, 2019, ⟨10.1111/ajt.15543⟩
American Journal of Transplantation, 2019, ⟨10.1111/ajt.15543⟩
American Journal of Transplantation, Wiley, 2019, ⟨10.1111/ajt.15543⟩
International audience; IL‐7 is an important cytokine for T cell lymphopoiesis. Blockade of the IL‐7 signal‐ing pathway has been shown to induce long‐term graft survival or graft tolerance in murine transplant models through inhibiting T cell
Autor:
Christophe Blanquart, Sophie Barillé-Nion, Kevin Biteau, Nicolas Poirier, Géraldine Teppaz, Charlène Trilleaud, Isabelle Girault, Caroline Mary, Vanessa Gauttier, Virginie Thepenier, Lyssia Belarif, Margot Lavy
Publikováno v:
Cancer Research. 81:1766-1766
Chronic inflammation is associated with abnormal non-phlogistic clearance (efferocytosis) of apoptotic cells by macrophages and a defect of the resolution of inflammation pathways. The resolution of inflammation is an active immunological process med
Autor:
Jeremy Hervouet, Lyssia Belarif, Vianney Charpy, Bernard Vanhove, David Minault, Simon Ville, Veronique Daguin, Caroline Mary, Melanie Chevalier, Gilles Blancho, Stéphanie Le Bas-Bernardet, Nicolas Poirier
Publikováno v:
mAbs
mAbs; Vol 6
mAbs; Vol 6
Antagonist anti-CD28 antibodies prevent T-cell costimulation and are functionally different from CTLA4Ig since they cannot block CTLA-4 and PDL-1 co-inhibitory signals. They demonstrated preclinical efficacy in suppressing effector T cells while enha
Autor:
Simon Ville, Gilles Blancho, Paul Baker, Lyssia Belarif, Stéphanie Le Bas-Bernardet, Nicolas Poirier, David Minault, Jeremy Hervouet, Elisabeth Cassagnau, Bernard Vanhove, Caroline Mary, Nahzli Dilek, Linda Scobie, Melanie Chevalier
Publikováno v:
Journal of Immunology
Journal of Immunology, 2016, 196 (1), pp.274-283. ⟨10.4049/jimmunol.1501810⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 196 (1), pp.274-283. ⟨10.4049/jimmunol.1501810⟩
Journal of Immunology, 2016, 196 (1), pp.274-283. ⟨10.4049/jimmunol.1501810⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 196 (1), pp.274-283. ⟨10.4049/jimmunol.1501810⟩
Novel therapies that specifically target activation and expansion of pathogenic immune cell subsets responsible for autoimmune attacks are needed to confer long-term remission. Pathogenic cells in autoimmunity include memory T lymphocytes that are lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6e639f003499feaa606422bec78a78
https://www.hal.inserm.fr/inserm-02150299/document
https://www.hal.inserm.fr/inserm-02150299/document
Autor:
LYSSIA BELARIF, Richard Danger, Laetitia Kermarrec, Véronique Daguin, Arnaud Boureille, Philippe Naveilhan, Bernard Vanhove, Nicolas Poirier
Publikováno v:
The Journal of Immunology. 200:42.1-42.1
Background and aims Signaling networks perpetuating chronic gastrointestinal inflammation in Crohn’s disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel diseases (IBD), remain unclear in man. Methods and results Accor