Výsledky vyhledávání - "Lysosomes/physiology"

Autor: Fulvio Reggiori, Christian Ungermann

Publikováno v: Reggiori, F & Ungermann, C 2017, ' Autophagosome Maturation and Fusion ', Journal of Molecular Biology, vol. 429, no. 4, pp. 486-496 . https://doi.org/10.1016/j.jmb.2017.01.002

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e217a53c2d1f1b3c9f19b78a1fd8773a
https://pure.au.dk/portal/da/publications/autophagosome-maturation-and-fusion(0ee7eb39-3659-48c2-94b2-640a65270e0c).html

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Elektronická kniha

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging : Volume 6- Regulation of Autophagy and Selective Autophagy

Autor: M. A. Hayat

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in

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Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Autor: Gautam Goel, Craig R. M. McKenzie, Szu Yu Kuo, Charles R. Mackay, Ramnik J. Xavier, Atul K. Bhan, Laurence Macia, Hailiang Huang, Muriel Mari, Leigh A. Baxt, Jakob Begun, Marcel Batten, Tatsuro Murano, Eduardo J. Villablanca, Fulvio Reggiori, Mark J. Daly, Kara G. Lassen

Publikováno v: Immunity, 44(6), 1392-1405. CELL PRESS
Immunity, 44(6), 1392. Cell Press
Lassen, K G, McKenzie, C I, Mari, M, Murano, T, Begun, J, Baxt, L A, Goel, G, Villablanca, E J, Kuo, S-Y, Huang, H, Macia, L, Bhan, A K, Batten, M, Daly, M J, Reggiori, F, Mackay, C R & Xavier, R J 2016, ' Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk ', Immunity, vol. 44, no. 6, pp. 1392-405 . https://doi.org/10.1016/j.immuni.2016.05.007

Although numerous polymorphisms have been associated with inflammatory bowel disease (IBD), identifying the function of these genetic factors has proved challenging. Here we identified a role for nine genes in IBD susceptibility loci in antibacterial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250306dbc72a56f308ed8b30f3abca03
https://research.rug.nl/en/publications/1c0a708e-f230-4aee-a7b4-2b38893b0928

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Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis

Autor: Dimitrios Galaris, Margarita Tenopoulou, Ulf T. Brunk, Alexandra Barbouti, Paschalis-Thomas Doulias

Publikováno v: Biochemical Journal. 387:703-710

Jurkat cells in culture were exposed to oxidative stress in the form of continuously generated hydrogen peroxide, obtained by the addition of glucose oxidase to the medium. This treatment induced a rapid, dose-dependent increase in the ICIP (intracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c45918a20ee1c9ab3406d24630462a
https://doi.org/10.1042/bj20041650

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Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer

Autor: Nicholas R. Lemoine, Joeri L. Aerts, Sarah K. Baird, Iain A. McNeish, Michelle Lockley, A Eddaoudi

Oncolytic adenoviral mutants have considerable activity in ovarian cancer. However, the mechanisms by which they induce cell death remain uncertain. dl922-947, which contains a 24 bp deletion in E1A CR2, is more potent than both E1A wild-type adenovi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ec6592658938d57547183a33dbcd54
https://hdl.handle.net/20.500.14017/0472a114-da41-41c7-b78a-129045e65399

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Role of phosphoinositide 3-kinase in the autophagic death of serum-deprived PC12 cells

Autor: Peter G.H. Clarke, M. X. P. van Bemmelen, A. Guillon-Munos

Publikováno v: Apoptosis : an International Journal on Programmed Cell Death, vol. 10, no. 5, pp. 1031-1041

The death of serum-deprived undifferentiated PC12 cells shows both autophagic and apoptotic features. Since it is still controversial whether the autophagy is instrumental in the cell death or a mere epiphenomenon, we tested the effects of inhibiting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766d5c9ff81f0f37c5da6fc96c940cfe
https://pubmed.ncbi.nlm.nih.gov/16151638

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CD14-dependent endotoxin internalization via a macropinocytic pathway

Autor: Jérôme Pugin, Jean-Louis Carpentier, Michelangelo Foti, Carine Poussin

Publikováno v: Journal of Biological Chemistry, Vol. 273, No 32 (1998) pp. 20285-20291

Gram-negative bacterial endotoxin (a lipopolysaccharide (LPS)) specifically binds to CD14, a glycosylphosphatidyl inositol (GPI)-anchored surface myeloid glycoprotein. This interaction leads to cell activation, but it also promotes LPS internalizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846fd24bb60aa3af028d00a1052aa695
https://pubmed.ncbi.nlm.nih.gov/9685378

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