Výsledky vyhledávání - "Lysosomes/metabolism"

Autor: Mario Mauthe, Harm H. Kampinga, Mark S. Hipp, Fulvio Reggiori

Publikováno v: Mauthe, M, Kampinga, H H, Hipp, M S & Reggiori, F 2023, ' Digest it all : the lysosomal turnover of cytoplasmic aggregates ', Trends in Biochemical Sciences, vol. 48, no. 3, pp. 216-228 . https://doi.org/10.1016/j.tibs.2022.09.012

Aggrephagy describes the selective lysosomal transport and turnover of cytoplasmic protein aggregates by macro-autophagy. In this process, protein aggregates and conglomerates are polyubiquitinated and then sequestered by autophagosomes. Soluble sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10c7d46ef3bd3e7b0bc5006b372d955
https://hdl.handle.net/11370/9caebdc8-3f8b-422a-b076-8cfd9ff4630d

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mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

Publikováno v: Nature Communications. 13(1)

The protein kinase mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth and proliferation, supporting anabolic reactions and inhibiting catabolic pathways like autophagy. Its hyperactivation is a frequent event in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::c7015ff21183a55e9e73de884b7c95cd
https://doi.org/10.1038/s41467-022-32487-7

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mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

Autor: Kaeser-Pebernard, Stephanie, Vionnet, Christine, Mari, Muriel, Sankar, Devanarayanan Siva, Hu, Zehan, Roubaty, Carole, Martinez-Martinez, Esther, Zhao, Huiyuan, Spuch-Calvar, Miguel, Petri-Fink, Alke, Rainer, Gregor, Steinberg, Florian, Reggiori, Fulvio, Dengjel, Joern

Publikováno v: Kaeser-Pebernard, S, Vionnet, C, Mari, M, Sankar, D S, Hu, Z, Roubaty, C, Martínez-Martínez, E, Zhao, H, Spuch-Calvar, M, Petri-Fink, A, Rainer, G, Steinberg, F, Reggiori, F & Dengjel, J 2022, ' mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 ', Nature Communications, vol. 13, no. 1, 4685 . https://doi.org/10.1038/s41467-022-32487-7
Nature Communications, 13(1). Nature Publishing Group
Nature Communications, 13(1):4685. Nature Publishing Group

mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0b6a00518154df4ad35bfaf4aade0ea4
https://pure.au.dk/portal/da/publications/mtorc1-controls-golgi-architecture-and-vesicle-secretion-by-phosphorylation-of-scyl1(32310649-10bb-427b-934c-d6c8be6b1464).html

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Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models

Autor: Mavroeidi, Panagiota, Arvanitaki, Fedra, Vetsi, Maria, Becker, Stefan, Vlachakis, Dimitrios, Jensen, Poul Henning, Stefanis, Leonidas, Xilouri, Maria

Publikováno v: Mavroeidi, P, Arvanitaki, F, Vetsi, M, Becker, S, Vlachakis, D, Jensen, P H, Stefanis, L & Xilouri, M 2022, ' Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models ', Autophagy, vol. 18, no. 9, pp. 2104-2133 . https://doi.org/10.1080/15548627.2021.2016256
Autophagy

Accumulation of the neuronal protein SNCA/alpha-synuclein and of the oligodendroglial phosphoprotein TPPP/p25A within the glial cytoplasmic inclusions (GCIs) represents the key histophathological hallmark of multiple system atrophy (MSA). Even though

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The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

Autor: Huber, K., Mestres-Arenas, A., Fajas, L., Leal-Esteban, L.C.

Publikováno v: The FEBS journal, vol. 288, no. 12, pp. 3813-3833

Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi-directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the famil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::7d0b37299c19a72cb95cc727ce46215e
https://serval.unil.ch/resource/serval:BIB_71F450E7C4FC.P001/REF.pdf

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Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4+ T Cells

Autor: Yan Zhou, Heiko Rieger, Mayis Kaba, Varsha Pattu, Rahmad Akbar, Bin Qu, Volkhard Helms, Renping Zhao, Eva C. Schwarz, Paula Nunes-Hasler

Publikováno v: The journal of immunology, Vol. 205, No 11 (2020) pp. 2988-3000

Delivery of vesicles to their desired destinations plays a central role in maintaining proper cell functionality. In certain scenarios, depending on loaded cargos, the vesicles have spatially distinct destinations. For example, in T cells, some cytok

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Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding

Autor: Kim Alexander Tønseth, Jens Eriksson, Alexander D. Rowe, Liesbeth M. C. Janssen, Catherine Jackson, Anna Połeć, Tor Paaske Utheim, Pernille Blicher, Stig Ove Bøe, Anna Ulrika Lång, Marijke Valk, Emma Lång

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications, 9(1):3665. Nature Publishing Group
Nature Communications

Epithelial sheet spreading is a fundamental cellular process that must be coordinated with cell division and differentiation to restore tissue integrity. Here we use consecutive serum deprivation and re-stimulation to reconstruct biphasic collective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1792da9b03e1d18e1a6f7eaad973187a
https://doaj.org/article/56730725888641c7b0f946697f96d47e

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Coordination of Autophagosome-Lysosome Fusion by Atg8 Family Members

Autor: Fulvio Reggiori, Christian Ungermann, Franziska Kriegenburg

Publikováno v: Kriegenburg, F, Ungermann, C & Reggiori, F 2018, ' Coordination of Autophagosome-Lysosome Fusion by Atg8 Family Members ', Current biology : CB, vol. 28, no. 8, pp. R512-R518 . https://doi.org/10.1016/j.cub.2018.02.034

Macroautophagy is a conserved intracellular lysosomal degradative pathway, vital for the maintenance of cellular homeostasis. It is characterized by double-membrane vesicles called autophagosomes, which sequester the cytoplasmic material destined for

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https://hdl.handle.net/11370/1fd81e71-f386-4e10-8ba9-1dd46350c31f

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Elektronická kniha

The Switch : Ignite Your Metabolism with Intermittent Fasting, Protein Cycling, and Keto

Autor: James W. Clement, Kristin Loberg

How can you lose weight, ease chronic conditions, and stay healthier longer? Discover how to “rewrite your health destiny” (David Perlmutter, MD, #1 New York Times bestselling author of Grain Brain) with this accessible book that teaches you how

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