Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Lysosomal transport"'
Publikováno v:
Nanoscale. 13:1016-1028
Benzo[a]pyrene (Bap) is one of the main organic pollutants in the atmospheric haze that is rich in fine water drops and particulate matters. The understanding of the Bap's form in water is of great importance to unveil its real biological effects tow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b9094e354d3dfe934c9f33c4a3a761e
https://doi.org/10.1039/d0nr06747d
https://doi.org/10.1039/d0nr06747d
Autor:
Katsuji Yoshioka, Purev Erdenebaatar, Ryusuke Suzuki, Jambaldorj Boldbaatar, Ravdandorj Odongoo, I Ketut Gunarta
Publikováno v:
Drug Discoveries & Therapeutics. 14:35-41
Lysosomes are involved in many cellular functions, and in turn lysosomal dysfunction underlies a variety of diseases, including cancer and neurodegenerative diseases. Lysosomes are distributed broadly in the cytoplasm and can move throughout the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9cfa249347ae88fb2ff005fe0297ef
https://doi.org/10.5582/ddt.2020.01001
https://doi.org/10.5582/ddt.2020.01001
Akademický článek
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Autor:
Insung Kang, Pamela Kell, Raffaella De Pace, Juan S. Bonifacino, Christopher A. Wassif, Michael E. Ward, Hideji Fujiwara, Xuntian Jiang, Forbes D. Porter, Anika V. Prabhu, Daniel S. Ory
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-12 (2021)
BMC Biology
BMC Biology
Background Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis, a lipid essential for cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee79e3bb6ebc51b855278dfe1ffbce8d
https://doi.org/10.1186/s12915-021-01133-x
https://doi.org/10.1186/s12915-021-01133-x
Autor:
Amra Saric
Lysosomes are essential organelles required for breakdown of endocytic and biosynthetic cargo, pathogen killing and autophagy. In most cells, lysosomes are typically small punctate structures. By contrast, innate immune cells like macrophages and den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b6e6a0b8585ee8a073722ddb96eb9f
https://doi.org/10.32920/ryerson.14663805
https://doi.org/10.32920/ryerson.14663805
Autor:
Junmei Zhang, Jenna L. Jewell, Adna Curukovic, Nicholas G. James, Qianmei Yang, Ting Sung Hsieh, Mi Hyeon Jeong, Chase H. Melick, Delong Meng, Brenden C. Park
Publikováno v:
The EMBO Journal
The mammalian target of rapamycin complex 1 (mTORC1) integrates nutrients, growth factors, stress, and energy status to regulate cell growth and metabolism. Amino acids promote mTORC1 lysosomal localization and subsequent activation. However, the sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25f74564a5fe08dae749cb2d5ef238b
http://europepmc.org/articles/PMC8204869
http://europepmc.org/articles/PMC8204869
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 9, Pp 1593-1603 (1999)
Prosaposin is the precursor of four lysosomal saposins that promote the degradation of glycosphingolipids (GSLs) by acidic hydrolases. GSLs contain a hydrophobic ceramide moiety, which acts as a membrane anchor, and a hydrophilic oligosaccharide chai
Externí odkaz:
https://doaj.org/article/004f6c895160446db72870c891356554
Autor:
Sreenath Nair, Avinash K. Persaud, Xiaolin Cheng, Debasis Nayak, Brenna Weadick, Craig A. McElroy, Radhika Raj, Muruganandan Shanmugam, Rajgopal Govindarajan, Sue E. Knoblaugh, Fazlur Rahman
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mutations in human equilibrative nucleoside transporter 3 (ENT3) encoded by SLC29A3 results in anemia and erythroid hypoplasia, suggesting that ENT3 may regulate erythropoiesis. Here, we demonstrate that lysosomal ENT3 transport of taurine-conjugated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2934d4caf93c4a6bc23bc9303779567
http://europepmc.org/articles/PMC7902824
http://europepmc.org/articles/PMC7902824
Publikováno v:
EBioMedicine, Vol 63, Iss, Pp 103166-(2021)
EBioMedicine
EBioMedicine
Lysosomal storage disorders (LSDs), which number over fifty, are monogenically inherited and caused by mutations in genes encoding proteins that are involved in lysosomal function. Lack of the functional protein results in storage of a distinctive ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c92e1bd8e73cf51246a741353c0b3a8
http://www.sciencedirect.com/science/article/pii/S2352396420305429
http://www.sciencedirect.com/science/article/pii/S2352396420305429
Autor:
Woojin Na, Hyeongjoo Oh, Yun-Ho Kim, Soo-Il Kim, Eun Jung Lee, Min-Kyung Kang, Su Yeon Oh, Dong Yeon Kim, Young-Hee Kang
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8581, p 8581 (2020)
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8581, p 8581 (2020)
For the optimal resorption of mineralized bone matrix, osteoclasts require the generation of the ruffled border and acidic resorption lacuna through lysosomal trafficking and exocytosis. Coumarin-type aesculetin is a naturally occurring compound with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22b4e7f8d9a569cc86a3cf9ab4a7e08
http://europepmc.org/articles/PMC7696459
http://europepmc.org/articles/PMC7696459