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Supplementary Figure 1, Tables 1-3 from Inactivation of the Dlc1 Gene Cooperates with Downregulation of p15INK4b and p16Ink4a, Leading to Neoplastic Transformation and Poor Prognosis in Human Cancer

Autor: Douglas R. Lowy, Nicholas C. Popescu, William C. Vass, Xu-Yu Yang, Lyra Olson, Brajendra K. Tripathi, Dunrui Wang, Marian E. Durkin, Xiaolan Qian

PDF file - 304K, Suppl. Table 1: Validated siRNAs used in the current studies Suppl. Fig. 1 Stress fiber formation in MEFs with or without v-Ras expression. Suppl. Fig. 2 The spontaneous transformation is reproducible using another Adeno-Cre treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcde8a1fba00e16c4831ea7f45eb4d81
https://doi.org/10.1158/0008-5472.22394400

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Data from Inactivation of the Dlc1 Gene Cooperates with Downregulation of p15INK4b and p16Ink4a, Leading to Neoplastic Transformation and Poor Prognosis in Human Cancer

Autor: Douglas R. Lowy, Nicholas C. Popescu, William C. Vass, Xu-Yu Yang, Lyra Olson, Brajendra K. Tripathi, Dunrui Wang, Marian E. Durkin, Xiaolan Qian

The tumor suppressor gene deleted in liver cancer-1 (DLC1), which encodes a protein with strong RhoGAP (GTPase activating protein) activity and weak Cdc42GAP activity, is inactivated in various human malignancies. Following Dlc1 inactivation, mouse e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d160bdb8d0db77be661194b8ded83740
https://doi.org/10.1158/0008-5472.c.6504021.v1

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Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

Autor: Erin E. Soule, Haixiang Yu, Lyra Olson, Ibtehaj Naqvi, Shekhar Kumar, Sriram Krishnaswamy, Bruce A. Sullenger

Publikováno v: Cell Chemical Biology

Coagulation cofactors profoundly regulate hemostasis and are appealing targets for anticoagulants. However, targeting such proteins has been challenging because they lack an active site. To address this, we isolate an RNA aptamer termed T18.3 that bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6451e3069a8fa0244d2154026266e2
http://europepmc.org/articles/PMC8808741

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DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists

Autor: Ibtehaj Naqvi, Nicholas Giroux, Lyra Olson, Sarah Ahn Morrison, Telmo Llanga, Tolu O. Akinade, Yuefei Zhu, Yiling Zhong, Shree Bose, Stephanie Arvai, Karen Abramson, Lingye Chen, Loretta Que, Bryan Kraft, Xiling Shen, Jaewoo Lee, Kam W. Leong, Smita K. Nair, Bruce Sullenger

Publikováno v: Biomaterials

Millions of COVID-19 patients have succumbed to respiratory and systemic inflammation. Hyperstimulation of toll-like receptor (TLR) signaling has been shown to be a key driver of immunopathology following infection by viruses. We found that severely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a550fd8e08fd7eb11e7f31918951fac1
https://pubmed.ncbi.nlm.nih.gov/35349874

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135: AGE AND COMORBIDITIES PREDICT COVID-19 OUTCOME REGARDLESS OF SEVERITY OF INNATE IMMUNE RESPONSE

Autor: Aditya Mohan, Lyra Olson, Ibtehaj Naqvi, Sarah Morrison, Bryan Kraft, Lingye Chen, Smita Nair, Bruce Sullenger, George Kasotakis

Publikováno v: Critical Care Medicine. 50:51-51

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f1e7050449806daddd55ef412f85caf
https://doi.org/10.1097/01.ccm.0000806864.34178.27

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