Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Lypaczewski P"'
Autor:
Patrick Lypaczewski, Yogesh Chauhan, Kayla Paulini, Lovlesh Thakur, Shailja Chauhan, Ezrah Isaac Roy, Greg Matlashewski, Manju Jain
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 9, Pp 1957-1959 (2024)
The clinical manifestation of leishmaniasis has historically been determined by the Leishmania species involved. However, recent emergence of novel Leishmania lineages has caused atypical pathologies. We isolated and characterized 2 new Leishmania do
Externí odkaz:
https://doaj.org/article/d113004227d14007977af4922b6a54c2
Autor:
Manju Jain, Diya A’gitok Sangma, Lipsalely Parida, Rohit Negi, Ajeet Negi, Greg Matlashewski, Patrick Lypaczewski
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Visceral leishmaniasis (VL) caused by L. donovani in South-East Asian endemic countries including India, Nepal and Bangladesh has been the primary focus of the ongoing VL elimination program. With a major reduction in VL cases resulting from the elim
Externí odkaz:
https://doaj.org/article/0139f64c117c49f4af6754e0e538688e
Autor:
Patrick Lypaczewski, Denise Chac, Chelsea N. Dunmire, Kristine M. Tandoc, Fahima Chowdhury, Ashraful I. Khan, Taufiqur R. Bhuiyan, Jason B. Harris, Regina C. LaRocque, Stephen B. Calderwood, Edward T. Ryan, Firdausi Qadri, B. Jesse Shapiro, Ana A. Weil
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Vibrio cholerae O1 causes the diarrheal disease cholera, and the small intestine is the site of active infection. During cholera, cholera toxin is secreted from V. cholerae and induces a massive fluid influx into the small intestine, which c
Externí odkaz:
https://doaj.org/article/99b2d2acaf2f4e868326c00551e9b2bd
Autor:
Ranadhir Dey, Jalal Alshaweesh, Kamaleshwar P. Singh, Patrick Lypaczewski, Subir Karmakar, Laura Klenow, Kayla Paulini, Swarnendu Kaviraj, Shaden Kamhawi, Jesus G. Valenzuela, Sanjay Singh, Shinjiro Hamano, Abhay R. Satoskar, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The leishmanin skin test was used for almost a century to detect exposure and immunity to Leishmania, the causative agent of leishmaniasis, a major neglected tropical disease. Due to a lack of antigen used for the intradermal injection, the
Externí odkaz:
https://doaj.org/article/11c3719514794468adb0c66ddc329d73
Akademický článek
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Autor:
Subir Karmakar, Greta Volpedo, Wen-Wei Zhang, Patrick Lypaczewski, Nevien Ismail, Fabiano Oliveira, James Oristian, Claudio Meneses, Sreenivas Gannavaram, Shaden Kamhawi, Shinjiro Hamano, Jesus G. Valenzuela, Greg Matlashewski, Abhay R. Satoskar, Ranadhir Dey, Hira L. Nakhasi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world. Currently, there is a lack of eff
Externí odkaz:
https://doaj.org/article/26413e213d76441788ba0d0d2b589f6a
Akademický článek
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Autor:
Greta Volpedo, Thalia Pacheco-Fernandez, Erin A. Holcomb, Wen-Wei Zhang, Patrick Lypaczewski, Blake Cox, Rebecca Fultz, Chelsea Mishan, Chaitenya Verma, Ryan H. Huston, Abigail R. Wharton, Ranadhir Dey, Subir Karmakar, Steve Oghumu, Shinjiro Hamano, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski, Abhay R. Satoskar
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Leishmaniasis is a neglected protozoan disease affecting over 12 million people globally with no approved vaccines for human use. New World cutaneous leishmaniasis (CL) caused by L. mexicana is characterized by the development of chronic non
Externí odkaz:
https://doaj.org/article/978c751f55954a559bd01abf5ad9b254
Autor:
Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Tomas Becvar, Patrick Lypaczewski, Eli Schwartz, Elizabeth Greensted, Katrien Van Bocxlaer, Marion Pasin, Kai S. Lipinski, Vivak Parkash, Greg Matlashewski, Alison M. Layton, Charles J. Lacey, Charles L. Jaffe, Petr Volf, Paul M. Kaye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Controlled human infection models (CHIMs) provide a pathway for accelerating vaccine development. Here, the authors describe the isolation, characterization, and GMP manufacture of a clinical Leishmania major strain to be used as a resource for CHIM
Externí odkaz:
https://doaj.org/article/ddd377d986694040985714870d5c4e1c
Autor:
Wen-Wei Zhang, Subir Karmakar, Sreenivas Gannavaram, Ranadhir Dey, Patrick Lypaczewski, Nevien Ismail, Abid Siddiqui, Vahan Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza-Vieira, Claudio Meneses, James Oristian, Tiago D. Serafim, Abu Musa, Risa Nakamura, Noushin Saljoughian, Greta Volpedo, Monika Satoskar, Sanika Satoskar, Pradeep K. Dagur, J. Philip McCoy, Shaden Kamhawi, Jesus G. Valenzuela, Shinjiro Hamano, Abhay R. Satoskar, Greg Matlashewski, Hira L. Nakhasi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, the authors engineer an attenuated knock-out Leishmania (LmCen −/−) vaccine that is safe in immunocompromised mice and induces an immune response and protection similar to leishmanization with wild-type Leishmania. Since LmCen −/− is an
Externí odkaz:
https://doaj.org/article/a50605a064c049859dfcd1fb76a10dad