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of 134
pro vyhledávání: '"Lyonel G. Israels and"'
Publikováno v:
APOPTOSIS. 6:57-68
Historically, the vitamin K1-dependent proteins have been associated primarily with blood coagulation and secondarily with bone formation. Recent identification of K1-dependent proteins as specific ligands for the receptor tyrosine kinases (RTKs) tha
Publikováno v:
STEM CELLS. 17:306-313
Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse informa
Autor:
Lyonel G. Israels, Esther D. Israels
Publikováno v:
The Oncologist. 4:332-339
Publikováno v:
STEM CELLS. 17:180-188
Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse informa
Autor:
Lyonel G. Israels, Esther D. Israels
Publikováno v:
The Oncologist. 4:129-137
Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse informa
Publikováno v:
Seminars in Perinatology. 21:90-96
Vitamin K in the fetus and newborn is maintained at levels less than that necessary to achieve full gamma-carboxylation of the K-dependent proteins, including those required for hemostasis. As the infant matures and even into adulthood, there is no s
Autor:
Kristine Lee, Paul Daeninck, James B. Johnston, Gaynor Williams, Lyonel G. Israels, Linda Verburg, Michael R. A. Mowat, Asher Begleiter
Publikováno v:
Leukemia & Lymphoma. 26:435-449
Most antitumor agents exert their cytotoxic effect through the induction of apoptosis, and this process may be mediated through an elevation in p53 protein, with a subsequent increase in bax and decrease in bcl-2. p53 also increases mdm-2 expression
Publikováno v:
Leukemia & Lymphoma. 23:187-201
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries but the clinical presentation and rate of disease progression are highly variable. When treatment is required the most commonly used therapy is the nitrogen mustard a
Autor:
Lyonel G. Israels, Esther D. Israels
Publikováno v:
Seminars in Thrombosis and Hemostasis. 21:357-363
The microsomal mixed function oxidase system metabolizes xenobiotics (Phase I) to products that, if not activated and conjugated for excretion (Phase II), are capable of forming conjugates with cellular macromolecules, including DNA, resulting in tox
Autor:
S.J. Israels, L. Schwartz, Linda Verburg, Lyonel G. Israels, Asher Begleiter, Michael R. A. Mowat, James B. Johnston
Publikováno v:
Leukemia Research. 17:81-87
TGF-beta is an important immunoregulator as it suppresses proliferation and function of B- and T-lymphocytes. In the present study we have examined the cellular localization and secretion of TGF-beta in B-cells from normal donors and patients with CL