Caco-2 cell acquisition of dietary iron(III) invokes a nanoparticulate endocytic pathway.

Autor: Dora I A Pereira, Bianca I Mergler, Nuno Faria, Sylvaine F A Bruggraber, Mohamad F Aslam, Lynsey K Poots, Laura Prassmayer, Bo Lönnerdal, Andy P Brown, Jonathan J Powell

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81250 (2013)

Dietary non-heme iron contains ferrous [Fe(II)] and ferric [Fe(III)] iron fractions and the latter should hydrolyze, forming Fe(III) oxo-hydroxide particles, on passing from the acidic stomach to less acidic duodenum. Using conditions to mimic the in

Externí odkaz: https://doaj.org/article/1bc1423b3da748a2b1466fd4796ad4b6

A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity

Autor: Sylvaine F. A. Bruggraber, Jonathan J. Powell, Nicole Hondow, Timothy J. Pennycook, Dora I. A. Pereira, Andy Brown, Gladys O. Latunde-Dada, Lynsey K. Poots, Nuno Jorge Rodrigues Faria, Robert J. Simpson

Publikováno v: Nanomedicine
Nanomedicine: nanotechnology, biology and medicine
Powell, J, Bruggraber, S, Faria, N, Poots, L K, Hondow, N, Pennycook, T J, Latunde-Dada, G, Simpson, R, Brown, A P & Pereira, D I A 2014, ' A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity ', Nanomedicine : nanotechnology, biology, and medicine, vol. 10, no. 7, pp. 1529-1538 . https://doi.org/10.1016/j.nano.2013.12.011

The 2-5 nm Fe(III) oxo-hydroxide core of ferritin is less ordered and readily bioavailable compared to its pure synthetic analogue, ferrihydrite. We report the facile synthesis of tartrate-modified, nano-disperse ferrihydrite of small primary particl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b8116270f920f54d1ea1ca159ba882