Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lynnette Koh"'
Autor:
Lynnette Koh, Wisna Novera, See Wee Lim, Yuk Kien Chong, Qing You Pang, David Low, Beng Ti Ang, Carol Tang
Publikováno v:
Pharmacological research. 182
This review describes recent technological advances applied to glioblastoma (GBM), a brain tumor with dismal prognosis. International consortial efforts suggest the presence of molecular subtypes within histologically identical GBM tumors. This empha
Autor:
Yuk Kien Chong, Edwin Sandanaraj, Beng Ti Ang, Nguan Soon Tan, Wai Hoe Ng, See Wee Lim, Melanie Si Yan Tan, Patrick Tan, Lynnette Koh, Carol Tang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Intratumoral heterogeneity is a hallmark of glioblastoma (GBM) tumors, thought to negatively influence therapeutic outcome. Previous studies showed that mesenchymal tumors have a worse outcome than the proneural subtype. Here we focus on STAT3 as its
Autor:
Shaomeng Wang, Yulun Huang, Ying Xu, Sigal Gery, Ruby Yu-Tong Lin, Tuan Zea Tan, Edwin Sandanaraj, See Wee Lim, John S. Yu, Kassoum Nacro, Moli Huang, Yuk Kien Chong, Anand Mayakonda, Ye Chen, Longchuan Bai, Hiroaki Wakimoto, Xin-Yu Ke, Jianxiang Chen, Liang Xu, Zhengyun Huang, Jeffrey Hill, H. Phillip Koeffler, Carol Tang, Pushkar Dakle, Beng Ti Ang, Lynnette Koh, Markus Müschen, Tseng Tsai Yeo
Publikováno v:
Science Advances
Profiling of active gene-regulatory DNA elements in brain cancer tissues illuminates disease biology and therapeutic targets.
Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylat
Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec6be9888aafd06c8ed01588bb0ced2
https://hdl.handle.net/10356/151048
https://hdl.handle.net/10356/151048
Autor:
See-Wee Lim, Patrick Tan, Carol Tang, Melanie Tan, Beng Ti Ang, Edwin Sandanaraj, Lynnette Koh, Wai Hoe Ng, Yuk-Kien Chong, Nguan-Soon Tan
Publikováno v:
Neuro Oncol
Glioblastoma (GBM) displays both spatial and temporal heterogeneity, whereupon mesenchymal tumors fare more poorly than the proneural molecular subtype. STAT3 was selected because its activation preceeds the proneural-mesenchymal transition. We first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfd275f6b4f54f590efbe2572c48799
https://europepmc.org/articles/PMC6847815/
https://europepmc.org/articles/PMC6847815/
Autor:
Ying Xu, Ruby Yu-Tong Lin, Carol Tang, Pushkar Dakle, Zhengyun Huang, Lynnette Koh, Kassoum Nacro, Longchuan Bai, Beng Ti Ang, Yuk Kien Chong, Anand Mayakonda, John S. Yu, Sigal Gery, Shaomeng Wang, Yulun Huang, Jeffrey Hill, Markus Müschen, Phillip Koeffler, Moli Huang, Xin-Yu Ke, Tseng Tsai Yeo, Tuan Zea Tan, Edwin Sandanaraj, Hiroaki Wakimoto, Jianxiang Chen, Yi Chen, See Wee Lim, Liang Xu
Publikováno v:
Cancer Research. 81:2123-2123
Background: Glioblastoma (GBM) is the most aggressive and therapy-refractory brain tumor in adults. Molecular profiling of GBM on the basis of gene expression, DNA methylation and genomic variations has advanced both cancer research and clinical diag
Autor:
Yuk Kien Chong, Anand Mayakonda, Ling-Wen Ding, Boon Cher Goh, Xin-Yu Ke, Dennis L. Buckley, Jianxiang Chen, Edwin Sandanaraj, James E. Bradner, H. Phillip Koeffler, See Wee Lim, Lynnette Koh, Liang Xu, Beng Ti Ang, Lingzhi Wang, Benjamin P. Berman, Huy Q. Dinh, Ye Chen, Carol Tang, Dennis Kappei, Moli Huang, Wendi Sun, Georg E. Winter, Ruby Yu-Tong Lin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 22
Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers. However, the BET protein-dependent glioblastoma (GBM)-promoting transcriptional network rem
Autor:
Yuk Kien Chong, Ivan Ng, Edwin Sandanaraj, Marie-Veronique Clement, Geraldene Rong-Hui Koh, Beng Ti Ang, Wai Hoe Ng, Shazib Pervaiz, Oi Lian Kon, Lynnette Koh, Greg Tucker-Kellogg, Tan Boon Toh, Carol Tang, Felicia Soo Lee Ng, Mark Phong
Publikováno v:
Antioxidants & Redox Signaling. 19:2261-2279
We explore the role of an elevated O2(-):H2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to apoptotic triggers.We observed that an elevated O2(-):H2O2 ratio conferred enh
Publikováno v:
Cell Biology: Research & Therapy.
Signalling Pathways in Glioma-Propagating Cells TGlioblastomas (GBMs) are highly aggressive and malignant brain tumors and have poor prognosis despite advanced surgical resections accompanied by chemo-radiation interventions.Current therapeutic advan
Autor:
Joanna D. Holbrook, Chou Chai, Yuk Kien Chong, Beng Ti Ang, Charlene S.F. Foong, Ryosuke Takahashi, Carol Tang, Jeanne M.M. Tan, Lynnette Koh, Edwin Sandanaraj, Geraldene Rong-Hui Koh, Calvin W.S. Yeo, Felicia Soo Lee Ng, Kah-Leong Lim
Publikováno v:
Cancer Research. 72:2543-2553
Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivat
Autor:
Yuk Kien Chong, Edwin Sandanaraj, Carol Tang, Kah-Leong Lim, Nguan Soon Tan, Joanna D. Holbrook, Ivan Ng, Moogaambikai Thangaveloo, Geraldene Rong-Hui Koh, Lynnette Koh, Melanie S. Y. Tan, Grace Lim, Tan Boon Toh, Wai Hoe Ng, Oi Lian Kon, Mahendran Nadarajah, Beng Ti Ang
Publikováno v:
JNCI Journal of the National Cancer Institute
Background: Cell surface sialylation is associated with tumor cell invasiveness in many cancers. Glioblastoma is the most malignant primary brain tumor and is highly infiltrative. ST3GAL1 sialyltransferase gene is amplified in a subclass of glioblast