Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Lynnette Knowles"'
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Akademický článek
Collagen XXVII organises the pericellular matrix in the growth plate.
Autor: Darren A Plumb, Laila Ferrara, Tanja Torbica, Lynnette Knowles, Aleksandr Mironov, Karl E Kadler, Michael D Briggs, Raymond P Boot-Handford
Publikováno v: PLoS ONE, Vol 6, Iss 12, p e29422 (2011)
In order to characterise the function of the novel fibrillar type XXVII collagen, a series of mice expressing mutant forms of the collagen were investigated. Mice harboring a glycine to cysteine substitution in the collagenous domain were phenotypica
Externí odkaz: https://doaj.org/article/bb2c337b73b34d669f54a6fd7866a0eb
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2
Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation
Autor: Raimund Wagener, Matthew Leighton, Michael D. Briggs, Tobias Starborg, Roger S. Meadows, Farhana Suleman, Lynnette Knowles, David J. Thornton, Karl E. Kadler, Seema Nundlall, Raymond P. Boot-Handford
Publikováno v: Human Molecular Genetics. 16:1728-1741
Disruption to endochondral ossification leads to delayed and irregular bone formation and can result in a heterogeneous group of genetic disorders known as the chondrodysplasias. One such disorder, multiple epiphyseal dysplasia (MED), is characterize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9726aa3d1a2c50bebbf8ba6ff2499639
https://doi.org/10.1093/hmg/ddm121
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3
Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress
Autor: Xin Wang, Katherine A. Hinchliffe, Raymond P. Boot-Handford, Andrew C Robinson, R Khosravi-Far, Lynnette Knowles, Cathy Tournier, Katherine G. Finegan
Publikováno v: Cell Death & Differentiation. 13:2099-2108
Extracellular signal-regulated protein kinase (ERK) 5 is a mitogen-activated protein kinase (MAPK) that is activated by dual phosphorylation via a unique MAPK/ERK kinase 5, MEK5. The physiological importance of this signaling cascade is underscored b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0f7be4f2c073530a75dd539156010b
https://doi.org/10.1038/sj.cdd.4401969
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5
Targeted induction of endoplasmic reticulum stress induces cartilage pathology
Autor: Rachel Eardley, Louise H. W. Kung, Richard Poulsom, Mel Heeran, Lynnette Knowles, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford, M. Helen Rajpar, Ben T. McDermott, Peter Arvan, Richard Wilson, Karl E. Kadler, David J. Thornton
Publikováno v: Rajpar, M H, McDermott, B, Kung, L, Eardley, R, Knowles, L, Heeran, M, Thornton, D J, Wilson, R, Bateman, J F, Poulsom, R, Arvan, P, Kadler, K E, Briggs, M D & Boot-Handford, R P 2009, ' Targeted induction of endoplasmic reticulum stress induces cartilage pathology ', PL o S Genetics, vol. 5, no. 10, e1000691 . https://doi.org/10.1371/journal.pgen.1000691
PLoS Genetics
PLoS Genetics, Vol 5, Iss 10, p e1000691 (2009)
Pathologies caused by mutations in extracellular matrix proteins are generally considered to result from the synthesis of extracellular matrices that are defective. Mutations in type X collagen cause metaphyseal chondrodysplasia type Schmid (MCDS), a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6820740417420de975724f13aaac4d58
https://doi.org/10.1371/journal.pgen.1000691
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6
Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP
Autor: Michael D. Briggs, Raymond P. Boot-Handford, Katarzyna A. Piróg-Garcia, David J. Thornton, Roger S. Meadows, Lynnette Knowles, Dick Heinegård, Karl E. Kadler
Publikováno v: Piróg-Garcia, K A, Meadows, R S, Knowles, L, Heinegård, D, Thornton, D J, Kadler, K E, Boot-Handford, R P & Briggs, M D 2007, ' Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP ', Human Molecular Genetics, vol. 16, no. 17, pp. 2072-2088 . https://doi.org/10.1093/hmg/ddm155
Pseudoachondroplasia (PSACH) is one of the more common skeletal dysplasias and results from mutations in cartilage oligomeric matrix protein (COMP). Most COMP mutations identified to date cluster in the TSP3 repeat region of COMP and the mutant prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4148defedf30484af4ba3019a31e9d9a
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:121471
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7
Collagen XXVII Organises the Pericellular Matrix in the Growth Plate
Autor: Alexander A. Mironov, Laila Ferrara, Darren A. Plumb, Raymond P. Boot-Handford, Lynnette Knowles, Tanja Torbica, Michael D. Briggs, Karl E. Kadler
Publikováno v: Plumb, D A, Ferrara, L, Torbica, T, Knowles, L, Mironov, A, Kadler, K E, Briggs, M D & Boot-Handford, R P 2011, ' Collagen XXVII organises the pericellular matrix in the growth plate ', PLoS ONE, vol. 6, no. 12, e29422 . https://doi.org/10.1371/journal.pone.0029422
PLoS ONE, Vol 6, Iss 12, p e29422 (2011)
PLoS ONE
In order to characterise the function of the novel fibrillar type XXVII collagen, a series of mice expressing mutant forms of the collagen were investigated. Mice harboring a glycine to cysteine substitution in the collagenous domain were phenotypica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f861eea78cac21a8a85a0392d6fa9b
https://doi.org/10.1371/journal.pone.0029422
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