Výsledky vyhledávání - "Lynnette J. Cook"

Lithium induces autophagy by inhibiting inositol monophosphatase

Autor: Lynnette J. Cook, Axelle Cordenier, Zdenek Berger, David C. Rubinsztein, Sovan Sarkar, Sara Imarisio, R. Andres Floto, Matthieu Y. Pasco

Publikováno v: The Journal of Cell Biology

Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins. Currently, the only suitable pharmacologic strategy for up-regulating autophagy in mammalian cells is to use rapamycin, which inhibits the mammalian target of ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8524a9df9c6289abfbcc19d15afb89
http://europepmc.org/articles/PMC2171537

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Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease

Publikováno v: Neuroscience Letters. 358:142-146

Consistent deficits in the cholinergic system are evident in Alzheimer's disease (AD) patients, including selective loss of alpha4beta2 nicotinic acetylcholine receptors in the brains of AD patients. Knockout mice for the beta2 subunit have impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e0b1b653b169f4d06201db03869de2
https://doi.org/10.1016/j.neulet.2004.01.016

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Decreased cAMP Response Element-mediated Transcription

Autor: Katharine L. Sugars, Lynnette J. Cook, David C. Rubinsztein, Rosemary Brown, Jina Swartz

Publikováno v: Journal of Biological Chemistry. 279:4988-4999

Huntington's disease (HD) is one of nine neurodegenerative diseases caused by an expanded polyglutamine (polyQ) tract within the disease protein. To characterize pathways induced early in HD, we have developed stable inducible PC12 cell lines express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b84a609486961773287af08327e0ee45
https://doi.org/10.1074/jbc.m310226200

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Identification of three genes expressed primarily during development in Physarum polycephalum

Autor: William F. Dove, Juliet Bailey, Jennifer Dee, Roger W. Anderson, Emma Swanston, Richard Kilmer-Barber, Lilianna Solnica-Krezel, Lynnette J. Cook, Karin N. Lohman

Publikováno v: Archives of Microbiology. 172:364-376

During the life cycle of Physarum polycephalum, uninucleate amoebae develop into multinucleate syncytial plasmodia. These two cell types differ greatly in cellular organisation, behaviour and gene expression. Classical genetic analysis has identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b3f986188fff2d7ca7dd95d318248b
https://doi.org/10.1007/s002030050773

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The effect of polymorphism at the serotonin transporter gene on decision-making, memory and executive function in ecstasy users and controls

Autor: Barbara J. Sahakian, Robert D. Rogers, Jonathan P. Roiser, Lynnette J. Cook

Publikováno v: Psychopharmacology. 188(2)

RATIONALE: 3, 4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a popular drug of abuse known to result in depletions of the serotonin (5-HT) system. A number of studies have reported that ecstasy users differ from controls on a variety of measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a785cd830b7e4269a91e1d8e2261cc
http://ora.ox.ac.uk/objects/uuid:ff1acc59-6935-4d98-bec3-514a2f603bdc

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Association of a Functional Polymorphism in the Serotonin Transporter Gene With Abnormal Emotional Processing in Ecstasy Users

Autor: Lynnette J. Cook, Jonathan P. Roiser, Jason D. Cooper, Barbara J. Sahakian, David C. Rubinsztein

The long-term effects of the use of 3,4-methylenedioxymethamphetamine (MDMA, or Ecstasy) in humans are controversial and unclear. The authors' goal was to assess the contribution of a functional polymorphism in the gene encoding serotonin transporter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ac440cdd9349a36d9d0678e8b91a50
https://europepmc.org/articles/PMC2631647/

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Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis

Autor: Katharine L, Sugars, Rosemary, Brown, Lynnette J, Cook, Jina, Swartz, David C, Rubinsztein

Publikováno v: The Journal of biological chemistry. 279(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cd50cdb808ea90d12d1e8715d6f9f2a
https://pubmed.ncbi.nlm.nih.gov/14627700

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Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy

Autor: Yi Ping Bao, Lynnette J. Cook, David C. Rubinsztein, Dominic G O'Donovan, Eiichiro Uyama

Publikováno v: The Journal of biological chemistry. 277(14)

Autosomal dominant oculopharyngeal muscular dystrophy (OPMD) is characterized pathologically by intranuclear inclusions in skeletal muscles and is caused by the expansion of a 10-alanine stretch to 12-17 alanines in the intranuclear poly(A)-binding p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6ab84365e3d26fcc8fd685645898ba
https://pubmed.ncbi.nlm.nih.gov/11796717

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Decoding Darkness - The Search for the Genetic Causes of Alzheimer's Disease

Autor: Lynnette J. Cook, Luk W. Ho, David C. Rubinsztein

Decoding Darkness - The Search for the Genetic Causes of Alzheimer's Disease. Rudolf E Tanzi, Ann B Parson. Cambridge, Massachusetts: Perseus Publishing, 2000. Alzheimer's disease currently affects an estimated 14 million people world wide. As the wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8517f504759d879deaae7a7a1d56c44f
https://europepmc.org/articles/PMC1734781/

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