Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lynnetta Watts"'
Autor:
Elif A. Oral, Abhimanyu Garg, Joseph Tami, Eric A. Huang, Louis St.L. O'Dea, Hartmut Schmidt, Anatoly Tiulpakov, Ann Mertens, Veronica J. Alexander, Lynnetta Watts, Eunju Hurh, Joseph L. Witztum, Richard S. Geary, Sotirios Tsimikas
Publikováno v:
Journal of Clinical Lipidology. 16:833-849
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a511815ca92594eaecdb3be627b967ea
https://doi.org/10.1016/j.jacl.2022.08.008
https://doi.org/10.1016/j.jacl.2022.08.008
Autor:
Joseph L. Witztum, Daniel Gaudet, Marcello Arca, Alan Jones, Handrean Soran, Ioanna Gouni-Berthold, Erik S.G. Stroes, Veronica J. Alexander, Richard Jones, Lynnetta Watts, Shuting Xia, Sotirios Tsimikas
Publikováno v:
Journal of clinical lipidology. Elsevier BV
Background: Familial chylomicronemia syndrome (FCS) is a rare, autosomal recessive genetic disorder characterized by a marked increase in plasma triglyceride (TG) levels and recurrent episodes of pancreatitis. The response to conventional TG-lowering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1052cc26ee75bd7c1928cdbf0b5957dc
https://pure.amc.nl/en/publications/volanesorsen-and-triglyceride-levels-in-familial-chylomicronemia-syndrome(a3f9f939-3b5b-42ec-bad2-09efad6f3b67).html
https://pure.amc.nl/en/publications/volanesorsen-and-triglyceride-levels-in-familial-chylomicronemia-syndrome(a3f9f939-3b5b-42ec-bad2-09efad6f3b67).html
Autor:
Louis O'Dea, Richard S. Geary, Eunju Hurh, Veronica J. Alexander, Kristin Balogh, Lynnetta Watts, Ewa Karwatowska-Prokopczuk, Sotirios Tsimikas
Publikováno v:
Nucleic Acid Therapeutics. 30:198-206
The aim of this study was to assess the effect of volanesorsen on the corrected QT (QTc) interval. This thorough QT study enrolled 52 healthy male and female subjects who were randomized at a singl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d58d2ba6edce51833df1ea253692149
https://doi.org/10.1089/nat.2019.0837
https://doi.org/10.1089/nat.2019.0837
Autor:
Martin Gajdošík, Julia K. Overman, Erin S. Morgan, Richard S. Geary, Li-Jung Tai, Shiangtung W. Jung, Lynnetta Watts, Brenda F. Baker, Martin Krššák, Michael Krebs, Sanjay Bhanot, Anne Smith, Nguyen C. Pham
Publikováno v:
Diabetes Care. 42:585-593
OBJECTIVE To evaluate the safety and efficacy of IONIS-GCGRRx, a 2′-O-methoxyethyl antisense oligonucleotide targeting the glucagon receptor (GCGR), and the underlying mechanism of liver transaminase increases in patients with type 2 diabetes on st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ebb99ae677c4e5967eefb37b6fa2fe
https://doi.org/10.2337/dc18-1343
https://doi.org/10.2337/dc18-1343
Autor:
Erin E. Morgan, Lisa A Hannan, Richard S. Geary, Rohit Loomba, Sanjay Bhanot, Shuting Xia, Brenda F. Baker, Lynnetta Watts
Publikováno v:
The lancet. Gastroenterology & hepatology, vol 5, iss 9
BackgroundDiacylglycerol-O-acyltransferase 2 (DGAT2) is one of two enzyme isoforms that catalyse the final step in the synthesis of triglycerides. IONIS-DGAT2Rx is an antisense oligonucleotide inhibitor of DGAT2 that is under clinical investigation f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09a68f43a88b8da38c592ef5d33deea
https://escholarship.org/uc/item/3q1381st
https://escholarship.org/uc/item/3q1381st
Autor:
Anatoly Tiulpakov, Elif Arioglu Oral, Eunju Hurh, Hartmut Schmidt, Lynnetta Watts, Louis O'Dea, Brant Hubbard, Joseph Tami, A. Garg, Ann Mertens, Veronica J. Alexander
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::480720e850948430ee9c1408f0287c9f
https://doi.org/10.1530/endoabs.70.aep269
https://doi.org/10.1530/endoabs.70.aep269
Autor:
Hartmut Schmidt, Eunju Hurh, Louis O'Dea, Brant Hubbard, Elif Arioglu Oral, Anatoly Tiulpakov, Joseph Tami, Veronica J. Alexander, Ann Mertens, A. Garg, Lynnetta Watts
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61348350a7098164a9495527af38255e
https://doi.org/10.1530/endoabs.70.oc3.7
https://doi.org/10.1530/endoabs.70.oc3.7
Autor:
Lynnetta Watts, Erin S. Morgan, Nguyen C. Pham, Richard S. Geary, Sanjay Bhanot, Andres DiGenio, Shiangtung W. Jung, Brenda F. Baker
Publikováno v:
Diabetes Care. 41:807-814
OBJECTIVE To evaluate safety and efficacy of IONIS-PTP-1BRx, a second-generation 2′-O-methoxyethyl antisense inhibitor of protein tyrosine phosphatase 1B, as add-on therapy in overweight patients with type 2 diabetes inadequately controlled with me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de1a71e83819b1a2b2fda5df493cbae
https://doi.org/10.2337/dc17-2132
https://doi.org/10.2337/dc17-2132
Autor:
Yanfeng Wang, Scott P. Henry, Sanjay Bhanot, Erin S. Morgan, Kenneth T. Luu, Lynnetta Watts, Richard S. Geary, Claudette Bethune, Anne Smith
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 44:179-191
IONIS-GCGRRx (ISIS 449884) is an antisense oligonucleotide inhibitor of the glucagon receptor (GCGR). The objective of this study was to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of IONIS-GCGRRx via population-based modeling. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7636f110567fa6059b9e232b4ca520df
https://doi.org/10.1007/s10928-017-9505-5
https://doi.org/10.1007/s10928-017-9505-5
Publikováno v:
Journal of Hepatology. 70:e67-e68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c32cc508aa50956cf8b3c1ab779c32
https://doi.org/10.1016/s0618-8278(19)30118-5
https://doi.org/10.1016/s0618-8278(19)30118-5