Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lynnetta M. Watts"'
Autor:
Xing Xian Yu, Lynnetta M Watts, Vara Prasad Manchem, Kaushik Chakravarty, Brett P Monia, Michael L McCaleb, Sanjay Bhanot
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66923 (2013)
Obesity is a primary risk factor for multiple metabolic disorders. Many drugs for the treatment of obesity, which mainly act through CNS as appetite suppressants, have failed during development or been removed from the market due to unacceptable adve
Externí odkaz:
https://doaj.org/article/4d1219a3b2e94f63b0bb77e501d3963a
Autor:
Lynnetta M, Watts, Ewa, Karwatowska-Prokopczuk, Eunju, Hurh, Veronica J, Alexander, Kristin, Balogh, Louis, O'Dea, Richard S, Geary, Sotirios, Tsimikas
Publikováno v:
Nucleic Acid Therapeutics
The aim of this study was to assess the effect of volanesorsen on the corrected QT (QTc) interval. This thorough QT study enrolled 52 healthy male and female subjects who were randomized at a single site in a four-way crossover study. Subjects were r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b369af3e0b2443c6936489b829e39bd3
https://pubmed.ncbi.nlm.nih.gov/32589506
https://pubmed.ncbi.nlm.nih.gov/32589506
Autor:
Erin S, Morgan, Li-Jung, Tai, Nguyen C, Pham, Julia K, Overman, Lynnetta M, Watts, Anne, Smith, Shiangtung W, Jung, Martin, Gajdošík, Martin, Krššák, Michael, Krebs, Richard S, Geary, Brenda F, Baker, Sanjay, Bhanot
Publikováno v:
Diabetes care. 42(4)
To evaluate the safety and efficacy of IONIS-GCGRIn three phase 2, randomized, double-blind studies, patients with type 2 diabetes on metformin received weekly subcutaneous injections of IONIS-GCGRSignificant reductions in HbAIONIS-GCGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdfee04115b485f4ba28d2de7675a073
https://pubmed.ncbi.nlm.nih.gov/30765435
https://pubmed.ncbi.nlm.nih.gov/30765435
Autor:
Andres, Digenio, Nguyen C, Pham, Lynnetta M, Watts, Erin S, Morgan, Shiangtung W, Jung, Brenda F, Baker, Richard S, Geary, Sanjay, Bhanot
Publikováno v:
Diabetes care. 41(4)
To evaluate safety and efficacy of IONIS-PTP-1BIn this phase II, double-blind, randomized, placebo-controlled, multicenter trial, overweight and obese patients (BMI ≥27 kg/mMean baseline HbACompared with placebo, IONIS-PTP-1B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2abe9a51cd98dea129a9af2ce74ace30
https://pubmed.ncbi.nlm.nih.gov/29439147
https://pubmed.ncbi.nlm.nih.gov/29439147
Autor:
Richard A. Angelo, Lynnetta M. Watts, Ronald E. Esser, Mark D. Murphey, Alan R. Hildebrand, Larry E. Baugh
Publikováno v:
Arthritis & Rheumatism. 38:129-138
Objective. To apply quantitative analytical methods to the evaluation of radiographic images in experimental arthritis. Methods. Adjuvant was used to induce arthritis in rats. Arthritis progression was followed by conventional methods. In addition, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d222cf49c0a07aecc1bdd1b7c77465
https://doi.org/10.1002/art.1780380120
https://doi.org/10.1002/art.1780380120
Autor:
David R. Borcherding, Matthew D. Linnik, Michael J. Parmely, Richard E. Long, Carl K. Edwards, Lynnetta M. Watts
Publikováno v:
Journal of Leukocyte Biology. 56:133-144
The effects of the carbocyclic nucleoside MDL 201,112 and the purine nucleoside adenosine on the interferon-γ (IFN-γ)-induced priming of macrophages (mfs) for the respiratory burst and major histocompatibility class II (MHC class II) Ia+ antigen ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0b9d8622b4907731de47c456c99a29
https://doi.org/10.1002/jlb.56.2.133
https://doi.org/10.1002/jlb.56.2.133
Autor:
Robert E. Smith, Richard A. Angelo, Larry P. Thornburg, Mark D. Murphey, Jamil W. Talhouk, James T. Palmer, Ronald E. Esser, Lynnetta M. Watts
Publikováno v:
Arthritis & Rheumatism. 37:236-247
Objective. To determine the effects of peptidyl fluoromethyl ketones on the in vitro activity of purified cathepsins B and L, on tissue cysteine proteinase activity, and on cartilage and bone destruction in experimental arthritis. Methods. The effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba64dbed2c119187f4c767414d6f1973
https://doi.org/10.1002/art.1780370213
https://doi.org/10.1002/art.1780370213
Autor:
Lynnetta M. Watts, George E. Pierce
Publikováno v:
Transplantation. 55:882-887
Mixed lymphoid chimeras can be established across H-2b--H-2d by injection of C57BL/6J (B-6) donor bone marrow cells into BALB/c hosts conditioned by sublethal irradiation, 235 cGy x3. These chimeras are specifically tolerant to both donor and host al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbc7640ba49f7e4efb8b42a55e92ed5
https://doi.org/10.1097/00007890-199304000-00037
https://doi.org/10.1097/00007890-199304000-00037
Autor:
Jeff Prior, Lorene A. Martin, Larry P. Thornburg, Ronald E. Esser, Lynnetta M. Watts, Nahed K. Ahmed, Jim Palmer
Publikováno v:
Biochemical Pharmacology. 44:1201-1207
Peptidyl fluoromethyl ketones (FMKs), with the amino acid sequence Phe-Ala held constant but with variable N-terminal groups, were synthesized and tested for inhibition of the cysteine proteinase cathepsin B. The FMKs were effective in inhibiting cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0212af6369f3b9f4fccbfc0ad4f202a
https://doi.org/10.1016/0006-2952(92)90385-v
https://doi.org/10.1016/0006-2952(92)90385-v
Publikováno v:
Cellular immunology. 162(2)
The expression of specific alleles of the human HLA-DR locus is associated with increased risk for the development of rheumatoid arthritis. Examination of the amine acid sequence of the DR β chain has revealed that risk for RA correlates with a clus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28eb183daeb148260b3932fd061f27c9
https://pubmed.ncbi.nlm.nih.gov/7743549
https://pubmed.ncbi.nlm.nih.gov/7743549