Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Lynne-Marie Postovit"'
Autor:
Tyler T. Cooper, Dylan Z. Dieters-Castator, Jiahui Liu, Gabrielle M. Siegers, Desmond Pink, Lorena Veliz, John D. Lewis, François Lagugné-Labarthet, Yangxin Fu, Helen Steed, Gilles A. Lajoie, Lynne-Marie Postovit
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Background The five-year prognosis for patients with late-stage high-grade serous carcinoma (HGSC) remains dismal, underscoring the critical need for identifying early-stage biomarkers. This study explores the potential of extracellular vesi
Externí odkaz:
https://doaj.org/article/9ae1b15f3d5847c1bbd54eb50095e5a9
Autor:
Jiesi Zhou, Yan Shu Kong, Krista M. Vincent, Dylan Dieters‐Castator, Amirali B. Bukhari, Darryl Glubrecht, Rong‐Zong Liu, Douglas Quilty, Scott D. Findlay, Xiaowei Huang, Zhihua Xu, Rui Zhe Yang, Lanyue Zhang, Emily Tang, Gilles Lajoie, David D. Eisenstat, Armin M. Gamper, Richard Fahlman, Roseline Godbout, Lynne‐Marie Postovit, YangXin Fu
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1763-1783 (2023)
Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults. The standard treatment achieves a median overall survival for GBM patients of only 15 months. Hence, novel therapies based on an increased understanding of
Externí odkaz:
https://doaj.org/article/919b27202fed43f09567395980a0f763
Autor:
HaEun Kim, Benjamin Lebeau, David Papadopoli, Predrag Jovanovic, Mariana Russo, Daina Avizonis, Masahiro Morita, Farzaneh Afzali, Josie Ursini-Siegel, Lynne-Marie Postovit, Michael Witcher, Ivan Topisirovic
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109188- (2024)
Summary: Emerging data suggest a significant cross-talk between metabolic and epigenetic programs. However, the relationship between the mechanistic target of rapamycin (mTOR), which is a pivotal metabolic regulator, and epigenetic modifications rema
Externí odkaz:
https://doaj.org/article/85ce26f1f1e64b648c909029a5dc76ef
Autor:
Tyler T Cooper, Lynne-Marie Postovit
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002297 (2023)
The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that docetaxel-induced injury of tumour stromal cells stimulates the release of cytokines that suppo
Externí odkaz:
https://doaj.org/article/4da6dfdabce547c7a6c8c4dec6477107
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-6 (2021)
Abstract Inflammatory breast cancer (IBC) is a rare, aggressive cancer found in all the molecular breast cancer subtypes. Despite extensive previous efforts to screen for transcriptional differences between IBC and non-IBC patients, a robust IBC-spec
Externí odkaz:
https://doaj.org/article/d8621330f63e4a94a8a6fa0081bb4648
Autor:
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca2+ channel IP3R3 and subsequently calcium transfer to the mitoc
Externí odkaz:
https://doaj.org/article/bf575d4233b14e5f997658655553d914
Autor:
Dylan Dieters-Castator, Paola M. Dantonio, Matt Piaseczny, Guihua Zhang, Jiahui Liu, Miljan Kuljanin, Stephen Sherman, Michael Jewer, Katherine Quesnel, Eun Young Kang, Martin Köbel, Gabrielle M. Siegers, Andrew Leask, David Hess, Gilles Lajoie, Lynne-Marie Postovit
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 375-390 (2021)
The tumor microenvironment (TME) is an important mediator of breast cancer progression. Cancer-associated fibroblasts constitute a major component of the TME and may originate from tissue-associated fibroblasts or infiltrating mesenchymal stromal cel
Externí odkaz:
https://doaj.org/article/12aee79287f34bb1b635b9f1f1242d5c
Autor:
Michael Jewer, Laura Lee, Matthew Leibovitch, Guihua Zhang, Jiahui Liu, Scott D. Findlay, Krista M. Vincent, Kristofferson Tandoc, Dylan Dieters-Castator, Daniela F. Quail, Indrani Dutta, Mackenzie Coatham, Zhihua Xu, Aakshi Puri, Bo-Jhih Guan, Maria Hatzoglou, Andrea Brumwell, James Uniacke, Christos Patsis, Antonis Koromilas, Julia Schueler, Gabrielle M. Siegers, Ivan Topisirovic, Lynne-Marie Postovit
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progressi
Externí odkaz:
https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90
Autor:
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/dd155e5301354bdea1495ad9acd130d1
Autor:
Sumanta Chatterjee, Vasudeva Bhat, Alexei Berdnikov, Jiahui Liu, Guihua Zhang, Edward Buchel, Janice Safneck, Aaron J. Marshall, Leigh C. Murphy, Lynne-Marie Postovit, Afshin Raouf
Publikováno v:
iScience, Vol 19, Iss , Pp 388-401 (2019)
Summary: Breast cancer-induced activated fibroblasts support tumor progression. However, the role of normal fibroblasts in tumor progression remains controversial. In this study, we used modified patient-derived organoid cultures and demonstrate that
Externí odkaz:
https://doaj.org/article/e2ec1c1892864a9d9d4ce305d8e93e07