Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort

Autor: Chris Parker, Lynne T. O'Brien, Daniel Leongamornlert, Amanda L. Hall, Koveela Govindasami, David Olmos, N. Mahmud, Tokhir Dadaev, Emma J. Sawyer, Chee L. Goh, Edward J. Saunders, Douglas F. Easton, Elizabeth Selvadurai, Zsofia Kote-Jarai, Ruth Woode-Amissah, Karen Thomas, Elena Castro, Rosalind A. Eeles, Malgorzata Tymrakiewicz, Rosemary A. Wilkinson, Michelle Guy, Ali Amin Al Olama

Publikováno v: BJU International. 112:666-673

What's known on the subject? and What does the study add? Family history (FH) is a major risk factor for the development of prostate cancer. The search for genetic variants has led to genome-wide association studies (GWAS), which have so far reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ccff682724e6defa9e9ccb3eb2a2024
https://doi.org/10.1111/j.1464-410x.2012.11648.x

Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis

Autor: Lynne T. O'Brien, Michelle Guy, David P. Dearnaley, R A Wilkinson, Z Kote-Jarai, Sameer Jhavar, Julia C. Meitz, Cyril Fisher, Doug Easton, D G R Evans, A. R. Norman, Alison Falconer, Matthew S. Forrest, Yolanda Barbachano, Elizabeth Page, Amanda L. Hall, Peter Osin, Sarah Bullock, S M Edwards, Questa Hope, Rosalind A. Eeles, Audrey Ardern-Jones, Beatrice N. Gehr-Swain

Publikováno v: British Journal of Cancer

Prostate cancer (PrCa) is a significant public health problem. In the European Union, approximately 200 000 men are diagnosed annually with the disease. There are 35 515 cases (Cancer Research UK, 2009a) per year in the United Kingdom and 10 239 deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff7f3c6de23f11eb20514e8fb929317
http://europepmc.org/articles/PMC2948551

Mutation analysis of the MSMB gene in familial prostate cancer

Autor: Rosemary A. Wilkinson, Michelle Guy, Rosalind A. Eeles, A A Al Olama, Daniel Leongamornlert, David E. Neal, Zsofia Kote-Jarai, Jenny L Donovan, Emma J. Sawyer, Doug Easton, Malgorzata Tymrakiewicz, Kenneth Muir, Amanda L. Hall, Lynne T. O'Brien, Jonathan J. Morrison, Freddie C. Hamdy

Publikováno v: British Journal of Cancer

Background: MSMB, a gene coding for β-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087e2a0f09352f415b79f24f0a3ae6c6
http://europepmc.org/articles/PMC2816656

Diagnostic radiation procedures and risk of prostate cancer

Autor: Polyxeni Dimitropoulou, Amanda L. Hall, Lynne T. O'Brien, Timothy J. Key, Puja R. Myles, S. Evans, Richard Pocock, Rosemary A. Wilkinson, Michelle Guy, B. Gehr-Swain, David P. Dearnaley, Douglas F. Easton, S. Edwards, Kenneth Muir, Rosalind A. Eeles, Artitaya Lophatananon

Publikováno v: British Journal of Cancer

Exposure to ionising radiation is an established risk factor for many cancers. We conducted a case-control study to investigate whether exposure to low dose ionisation radiation from diagnostic x-ray procedures could be established as a risk factor f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837aa0c6b4cb49adc763fed3aa4344fd
https://doi.org/10.1038/sj.bjc.6604370

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Autor: Cao G-W., Joanne L. Dickinson, Gianluca Severi, Tokhir Dadaev, Alan Horwich, S. Lindstrom, Sonja I. Berndt, Jong Y. Park, Shannon K. McDonnell, Lin H-Y., Amit Joshi, Daniel Leongamornlert, Johanna Schleutker, Robert Huddart, Zhang H-W., Ruth Frikke-Schmidt, Melissa C. Southey, Amanda B. Spurdle, Jan Adolfsson, Michael Gaziano, David G. Cox, Elio Riboli, Erika M. Kwon, Jyotsna Batra, K. Govindasami, Amanda L. Hall, Karina Dalsgaard Sørensen, S. Benlloch, E. Saunders, Vanio Mitev, Paula Kujala, Chris Ogden, Peter Kraft, Anssi Auvinen, S. J. Chanock, Vincent Khoo, Kathleen Herkommer, Michael Borre, C. Slavov, Rosalind A. Eeles, Heiko Müller, Lisa A. Cannon-Albright, D J Schaid, David E. Neal, Doug Easton, Tammela Tlj., W. R. Diver, E J Sawyer, Martin Andreas Røder, Afshan Siddiq, Jianfeng Xu, Michelle Guy, Andreas Meyer, Joanne F. Aitken, Shintaro Narita, Michael J. Thun, Malgorzata Tymrakiewicz, James R. Marthick, Torben F. Ørntoft, Lynne T. O'Brien, Edward Giovannucci, R A Wilkinson, Fredrick R. Schumacher, Mariana C. Stern, Zsofia Kote-Jarai, Antje E. Rinckleb, Ahva Shahabi, Jarmo Virtamo, T A Sellers, Christiane Maier, C.R.J. Woodhouse, Pedro Vaz Pinto, Sue A. Ingles, Cezary Cybulski, Jenny L Donovan, Anna M. Ray, Henrik Grönberg, Markus Aly, Kenneth Muir, Suzanne K. Chambers, Tim Dudderidge, Danielle M. Karyadi, Judith A. Clements, Briony Patterson, Susan M. Gapstur, Manuel Luedeke, Demetrius Albanes, Federico Canzian, B. E. Henderson, Elaine A. Ostrander, Thilo Dörk, John L. Hopper, Fredrik Wiklund, Lu Y-J., Timothy J. Key, Meredith Yeager, Robert A. Stephenson, Liesel M. FitzGerald, Robert A. Gardiner, Ali Amin Al Olama, Manuel R. Teixeira, Rudolph Kaaks, David P. Dearnaley, Hermann Brenner, Kathleen A. Cooney, Maren Weischer, Jan Lubinski, Angela Cox, Aritaya Lophatonanon, Ruth C. Travis, Jürgen Serth, Suzanne Kolb, David J. Hunter, Stig E. Bojesen, Felicity Lose, Jonathan J. Morrison, Dominika Wokołorczyk, W. Vogel, W. Isaacs, Freddie C. Hamdy, Siqun L. Zheng, N. van As, A. Thompson, N. Mahmud, Dallas R. English, S. N. Thibodeau, Roman Corral, Janet L. Stanford, Colin Cooper, Norihiko Tsuchiya, Gerald L. Andriole, T. Wahlfors, D Campa, Craig C. Teerlink, Kimmo Taari, Tomonori Habuchi, Esther M. John, Chris Parker, Richard B. Hayes, Dietrich Rothenbacher, João Vasco Santos, Børge G. Nordestgaard, Radka Kaneva, Peter Klarskov, Christopher A. Haiman, Loic Le Marchand, Graham G. Giles

Publikováno v: Amin Al Olama, A, Kote-Jarai, Z, Schumacher, F R, Wiklund, F, Berndt, S I, Benlloch, S, Giles, G G, Severi, G, Neal, D E, Hamdy, F C, Donovan, J L, Hunter, D J, Henderson, B E, Thun, M J, Gaziano, M, Giovannucci, E L, Siddiq, A, Travis, R C, Cox, D G, Canzian, F, Riboli, E, Key, T J, Andriole, G, Albanes, D, Hayes, R B, Schleutker, J, Auvinen, A, Tammela, T L J, Weischer, M, Stanford, J L, Ostrander, E A, Cybulski, C, Lubinski, J, Thibodeau, S N, Schaid, D J, Sorensen, K D, Batra, J, Clements, J A, Chambers, S, Aitken, J, Gardiner, R A, Maier, C, Vogel, W, Dörk, T, Brenner, H, Habuchi, T, Ingles, S, John, E M, Orntoft, T F, Borre, M & The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2013, ' A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease ', Human Molecular Genetics . https://doi.org/10.1093/hmg/dds425

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad9635bdca894a7ceabe93a36b9adbd
http://ora.ox.ac.uk/objects/uuid:893cadad-9be1-489c-98c8-8d1839820f96