Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lynne Ramage"'
Autor:
Nicholas M Morton, Yvonne B Nelson, Zoi Michailidou, Emma M Di Rollo, Lynne Ramage, Patrick W F Hadoke, Jonathan R Seckl, Lutz Bunger, Simon Horvat, Christopher J Kenyon, Donald R Dunbar
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23944 (2011)
BACKGROUND:Obesity and metabolic syndrome results from a complex interaction between genetic and environmental factors. In addition to brain-regulated processes, recent genome wide association studies have indicated that genes highly expressed in adi
Externí odkaz:
https://doaj.org/article/beb69d9e6dde4131b90e2f3a8bdbed1f
Autor:
Karla Suchacki, Lynne Ramage, Calum Gray, Blanco Giovanny Rodrguez, Kwok T'ng Choong, Luke Boyle, Gillian MacNaught, Maria-lena Gregoriades, Sonia Wakelin, Kriegsheim Alex von, Andrew Finch, Dilip Patel, Beek Edwin van, Roland Stimson
Publikováno v:
Endocrine Abstracts.
Autor:
Alexandra Kelman, Lynne Ramage, Roland Stimson, Joanna Simpson, Stewart Rodney, Beek Edwin van, Karla J. Suchacki, Sonia J. Wakelin, Alison Fletcher, Roderick N. Carter, Kwok T’ng Choong, Nicholas M. Morton, Natalie Z.M. Homer, Gillian Macnaught, Jonathan Manning, Matthew Keegan, Calum Gray, Ben T McNeill
Publikováno v:
Endocrine Abstracts.
Publikováno v:
Endocrine Abstracts.
Autor:
Sergio Rodriguez-Cuenca, Gary A. Churchill, Antonio Vidal-Puig, Maximilian Zeyda, Nicholas M. Morton, Annalisa Gastaldello, Jasmina Beltram, Scott P. Webster, Gregor Gorjanc, Aila Saari, Thomas M. Stulnig, Simon Horvat, Vilmundur Gudnason, Roderick N. Carter, Matthew T G Gibbins, José Manuel Fernández-Real, Jonathan R. Seckl, Steven C. Munger, Clare McFadden, Gregorio Naredo, Martin E. Barrios-Llerena, Donald R. Dunbar, Christopher J Kenyon, Zhao V. Wang, Alexander F. Howie, Lynne Ramage, José María Moreno-Navarrete, Karen L. Svenson, Brian R. Walker, Valur Emilsson, Petra Sipilä, Zoi Michailidou, Rhona Aird
Publikováno v:
Morton, N M, Beltram, J, Carter, R N, Michailidou, Z, Gorjanc, G, McFadden, C, Barrios-Llerena, M E, Rodriguez-Cuenca, S, Gibbins, M T G, Aird, R E, Moreno-Navarrete, J M, Munger, S C, Svenson, K L, Gastaldello, A, Ramage, L, Naredo, G, Zeyda, M, Wang, Z V, Howie, A F, Saari, A, Sipilä, P, Stulnig, T M, Gudnason, V, Kenyon, C J, Seckl, J R, Walker, B R, Webster, S P, Dunbar, D R, Churchill, G A, Vidal-Puig, A, Fernandez-Real, J M, Emilsson, V & Horvat, S 2016, ' Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness ', Nature Medicine, vol. 22, no. 7, pp. 771-779 . https://doi.org/10.1038/nm.4115
Nature medicine
© Nature Medicine, 2016, vol. 22, p. 771-779
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
instname
Nature medicine
© Nature Medicine, 2016, vol. 22, p. 771-779
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
instname
The discovery of genetic mechanisms for resistance to obesity and diabetes may illuminate new therapeutic strategies for the treatment of this global health challenge. We used the polygenic 'lean' mouse model, which has been selected for low adiposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d97883a5e7915270071cddd2f0f72e6
https://hdl.handle.net/2072/372198
https://hdl.handle.net/2072/372198
Autor:
Calum Gray, Domenico Mattiucci, Carlos J. Alcaide-Corral, Antonella Poloni, Benjamin J. Thomas, Saverio Cinti, Giorgos Papanastasiou, Erica L. Scheller, Karla J. Suchacki, Richard J Sulston, Jack Andrews, Robert Wallace, Marc R. Dweck, Amanda J. Drake, Diana Said, Nicholas M. Morton, William P. Cawthorn, Ormond A. MacDougald, Bonnie M. Nicholson, Andrea Lovdel, Matthew C. Sinton, Edwin Jacques Rudolph van Beek, Adriana Tavares, Wendy McDougald, Gavin J. Macpherson, Michelle C. Williams, Lynne Ramage, Roland H Stimson
SUMMARYBone marrow adipose tissue (BMAT) represents >10% of total adipose mass, yet unlike white or brown adipose tissues (WAT or BAT), its role in systemic metabolism remains unclear. Using transcriptomics, we reveal that BMAT is molecularly distinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b82536557a896a96cee3b468ed0a2b
Autor:
Brian R. Walker, Scott P. Webster, Donald R. Dunbar, Nicholas M. Morton, X. Liu, Sophie Turban, Lynne Ramage, John J. Mullins, Jonathan R. Seckl
Publikováno v:
Diabetes
Turban, S, Liu, X, Ramage, L, Webster, S P, Walker, B R, Dunbar, D R, Mullins, J J, Seckl, J R & Morton, N M 2012, ' Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure ', Diabetes, vol. 61, no. 3, pp. 642-652 . https://doi.org/10.2337/db11-1054
Turban, S, Liu, X, Ramage, L, Webster, S P, Walker, B R, Dunbar, D R, Mullins, J J, Seckl, J R & Morton, N M 2012, ' Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure ', Diabetes, vol. 61, no. 3, pp. 642-652 . https://doi.org/10.2337/db11-1054
Type 2 diabetes ultimately results from pancreatic β-cell failure. Abnormally elevated intracellular regeneration of glucocorticoids by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in fat or liver may underlie pathophysiological a
Autor:
Martin E. Barrios-Llerena, Petra Sipilä, Annalisa Gastaldello, Sergio Rodriguez-Cuenca, José Manuel Fernández-Real, Rhona Aird, Gregor Gorjanc, Jasmina Beltram, Zoi Michailidou, Thomas M. Stulnig, Gary A. Churchill, Zhao V. Wang, Nicholas M. Morton, Clare McFadden, Aila Saari, Maximilian Zeyda, Vilmundur Gudnason, Donald R. Dunbar, Simon Horvat, Christopher J. Kenyon, José María Moreno-Navarrete, Antonio Vidal-Puig, Brian R. Walker, Valur Emilsson, Jonathan R. Seckl, Steven C. Munger, Karen L. Svenson, Lynne Ramage, Roderick N. Carter, Matthew T G Gibbins, Gregorio Naredo, Alexander F. Howie, Scott P. Webster
Publikováno v:
Nature Medicine. 24:525-525
Nat. Med. 22, 771–779 (2016); published online 6 June 2016; corrected after print 7 March 2018 In the version of this article initially published, the colors of the lines were switched in the graph that shows the glucose infusion rates for wild-typ
Autor:
Nicholas M. Morton, Jonathan R. Seckl, Lynne Ramage, Erin E. Kershaw, Harveen Dhillon, Jeffrey S. Flier
Publikováno v:
Kershaw, E E, Morton, N M, Dhillon, H, Ramage, L, Seckl, J R & Flier, J S 2005, ' Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity ', Diabetes, vol. 54, no. 4, pp. 1023-1031 . https://doi.org/10.2337/diabetes.54.4.1023
Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11 beta-hydroxysteroid dehydrogenases (11 beta HSDs). 11 beta HSD1 activates GCs, while 11 beta HSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgeni
Publikováno v:
Endocrinology. 145:2707-2712
The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) amplifies intracellular glucocorticoid action in vivo. 11β-HSD-1 activity is increased in adipose tissues of obese humans and genetically obese rodents, providing a mechanistic basis f