Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Lynne R. Prince"'
Autor:
Lynne R. Prince, Sheila E. Francis
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 7 (2023)
Externí odkaz:
https://doaj.org/article/42d9aac8b92749eda9d91087db1c86ca
Autor:
Kimberly D. Herman, Carl G. Wright, Helen M. Marriott, Sam C. McCaughran, Kieran A. Bowden, Mark O. Collins, Stephen A. Renshaw, Lynne R. Prince
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in inflamed tissues. Therapeutic induction of neutrophil apoptosis, a
Externí odkaz:
https://doaj.org/article/3b6a66ae4ab6401e9ef5f5cc7bbfbef5
Autor:
Rebecca Dowey, Joby Cole, A.A. Roger Thompson, Rebecca C. Hull, Chenghao Huang, Jacob Whatmore, Ahmed Iqbal, Kirsty L. Bradley, Joanne McKenzie, Allan Lawrie, Alison M. Condliffe, Endre Kiss-Toth, Ian Sabroe, Lynne R. Prince
Publikováno v:
ERJ Open Research, Vol 8, Iss 2 (2022)
Background Neutrophil extracellular traps (NETs) are web-like DNA and protein lattices which are expelled by neutrophils to trap and kill pathogens, but which cause significant damage to the host tissue. NETs have emerged as critical mediators of lun
Externí odkaz:
https://doaj.org/article/939c2b6703794211b009663901e36f25
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D, T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes of the innate immune system that are critical in pathogen handling. Ne
Externí odkaz:
https://doaj.org/article/de5da14c8a24478db0f8b21ff82f8ba0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
How multifunctional cells such as macrophages interpret the different cues within their environment and undertake an appropriate response is a key question in developmental biology. Understanding how cues are prioritized is critical to answering this
Externí odkaz:
https://doaj.org/article/28ec25dc15114a209e8daaabb7fce421
Autor:
Atiqur Rahman, Katherine M Henry, Kimberly D Herman, Alfred AR Thompson, Hannah M Isles, Claudia Tulotta, David Sammut, Julien JY Rougeot, Nika Khoshaein, Abigail E Reese, Kathryn Higgins, Caroline Tabor, Ian Sabroe, William J Zuercher, Caroline O Savage, Annemarie H Meijer, Moira KB Whyte, David H Dockrell, Stephen A Renshaw, Lynne R Prince
Publikováno v:
eLife, Vol 8 (2019)
Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me
Externí odkaz:
https://doaj.org/article/fe7fcfe76891424e9fe5d095f6489f95
Autor:
Hannah M. Isles, Kimberly D. Herman, Anne L. Robertson, Catherine A. Loynes, Lynne R. Prince, Philip M. Elks, Stephen A. Renshaw
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrat
Externí odkaz:
https://doaj.org/article/e3c17c21cf4049ceb1d3ced802a3e8bb
Autor:
Bethany M. Hughes, Charlotte S. Burton, Abigail Reese, Maisha F. Jabeen, Carl Wright, Jessica Willis, Nika Khoshaein, Elizabeth K. Marsh, Peter Peachell, Shao C. Sun, David H. Dockrell, Helen M. Marriott, Ian Sabroe, Alison M. Condliffe, Lynne R. Prince
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Non-typeable Haemophilus influenzae (NTHi) is a frequent cause of lower respiratory tract infection in people with chronic obstructive pulmonary disease (COPD). Pellino proteins are a family of E3 ubiquitin ligases that are critical regulators of TLR
Externí odkaz:
https://doaj.org/article/0a33add6275f446386843c1bf0f878db
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Staphylococcus aureus is a commensal organism in approximately 30% of the human population and colonization is a significant risk factor for invasive infection. As a result of this, there is a great need to better understand how S. aureus overcomes h
Externí odkaz:
https://doaj.org/article/3850a8d6aec647f39e0a14b7d4d0d8ef
Autor:
Kimberly D Herman, Carl G Wright, Helen M Marriott, Sam C McCaughran, Mark O Collins, Stephen A Renshaw, Lynne R Prince
Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in inflamed tissues. Therapeutic induction of neutrophil apoptosis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::004315f8bbde118b21b6d3a764ce9910
https://doi.org/10.1101/2022.04.14.488364
https://doi.org/10.1101/2022.04.14.488364
