Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Lynne Lennard"'
Publikováno v:
International Journal of Laboratory Hematology. 40:e38-e40
Autor:
Lynne Lennard
Publikováno v:
British Journal of Clinical Pharmacology. 77:704-714
The activity of the enzyme thiopurine methyltransferase (TPMT) is regulated by a common genetic polymorphism. One in 300 individuals lack enzyme activity and 11% are heterozygous for a variant low activity allele and have an intermediate activity. Th
Publikováno v:
British Journal of Clinical Pharmacology. 76:125-136
Aims In children with acute lymphoblastic leukaemia (ALL) bone marrow activity can influence red blood cell (RBC) kinetics, the surrogate tissue for thiopurine methyltransferase (TPMT) measurements. The aim of this study was to investigate TPMT pheno
Autor:
Howard L. McLeod, Lynne Lennard, Elke Schaeffeler, Joan M. Hebert, Ellen M. McDonagh, Mary V. Relling, Richard M. Weinshilboum, Malin Lindqvist Appell, Matthias Schwab, Tony Marinaki, William E. Evans, Sally A. Coulthard, Teri E. Klein, Jonathan S. Berg, John A. Duley, Allen Eng Juh Yeoh, Martin A. Kennedy
Publikováno v:
Pharmacogenetics and Genomics. 23:242-248
The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice. TPMT metabolizes the thiopurines 6-mercaptopurine, 6-thioguanine, and azathiopri
Autor:
J. S. Lilleyman, Chris Mitchell, T Eden, Susan M. Richards, Ajay Vora, S Kinsey, Cher S. Cartwright, Lynne Lennard
The UK MRC ALL97 trial included a randomised comparison of the efficacy and toxicity of dexamethasone and thioguanine (TG, experimental arms) with prednisolone and mercaptopurine (MP). The cytotoxic effects of MP and TG are mediated, in part, by thio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bbb6cba6cd24580db9d8608fdbf204
https://ora.ox.ac.uk/objects/uuid:c9374826-1b1c-4929-bd37-40ee8edd73ff
https://ora.ox.ac.uk/objects/uuid:c9374826-1b1c-4929-bd37-40ee8edd73ff
Autor:
Lynne Lennard, Dermot Gleeson, Sarah Schneider, Elizabeth L. Thornhill, E McFarlane, H Dhaliwal, Rory Anderson
Publikováno v:
Hepatology. 56:1401-1408
Azathioprine (AZA) is used to maintain remission in autoimmune hepatitis (AIH), but up to 18% of patients are unresponsive. AZA is a prodrug, and the formation of active thioguanine nucleotide (TGN) metabolites varies widely. We aimed to assess the r
Publikováno v:
Journal of clinical pathology. 69(4)
Aims To assess the value of laboratory tests available for the investigation of iron status in a population of young British South Asian children. Methods Blood count, red cell distribution width (RDW), percentage hypochromic red cells (%hypo), conce
Publikováno v:
British Journal of Haematology
The influence of thiopurine methyltransferase (TPMT) genotype on treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia trial ALL2003, a trial in which treatment intensity was adjusted based on minimal residu
Publikováno v:
Cancer Chemotherapy and Pharmacology. 50:33-36
Purpose. The aim of this study was to compare leucocyte and erythrocyte thioguanine nucleotide (TGN) cytotoxic metabolite concentrations in children with lymphoblastic leukaemia taking mercaptopurine (MP) or thioguanine (TG) as part of their long-ter
Publikováno v:
British Journal of Haematology
Summary The impact of thiopurine methyltransferase (TPMT) genotype on thiopurine dose intensity, myelosuppression and treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia (ALL) trial ALL97. TPMT heterozygot