Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lynne J. Lawrence"'
Autor:
Angela Luttick, Lynne J. Lawrence, Melinda Lowe, Bo Lin, Michael W. Parker, Jayne Sullivan, Rachel Cameron, Michael J. Smout, J.L. McKimm-Breschkin, Jane Ryan, Craig J. Morton, Simon P. Tucker, Paul R. Young, Anthony J. Mason
Publikováno v:
Virology. 311:275-288
Respiratory syncytial virus (RSV) is a ubiquitous human pathogen and the leading cause of lower respiratory tract infections in infants. Infection of cells and subsequent formation of syncytia occur through membrane fusion mediated by the RSV fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cce35eadcad8ca5ed073038bd32fd79
https://doi.org/10.1016/s0042-6822(03)00115-6
https://doi.org/10.1016/s0042-6822(03)00115-6
Publikováno v:
FEBS Letters. 494:220-224
Lipid-free human apolipoprotein C-II (apoC-II) forms amyloid fibrils with characteristic beta-structure. This conformation is distinct from the alpha-helical fold of lipid-bound apoC-II. We have investigated the effect of the short-chain phospholipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bfc66885da84be29868a67b2a19b4b
https://doi.org/10.1016/s0014-5793(01)02355-9
https://doi.org/10.1016/s0014-5793(01)02355-9
Autor:
P.A. Tulloch, Brian J. Smith, Lynne J. Lawrence, J.L. McKimm-Breschkin, Jeffrey J Gorman, Peter M. Colman, Michael C. Lawrence, Lin Chen
Publikováno v:
Structure. 9(3):255-266
Background: Membrane fusion within the Paramyxoviridae family of viruses is mediated by a surface glycoprotein termed the "F", or fusion, protein. Membrane fusion is assumed to involve a series of structural transitions of F from a metastable (prefus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766a2e7302964c5b9500f9b2d17b4992
Publikováno v:
Biochemistry. 39:8276-8283
Human apolipoprotein C-II (apoC-II) self-associates in solution to form aggregates with the characteristics of amyloid including red-green birefringence in the presence of Congo Red under cross-polarized light, increased fluorescence in the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60460fcd99bc85ea87f7a44856a4f505
https://doi.org/10.1021/bi000002w
https://doi.org/10.1021/bi000002w
Autor:
Alexander A. Kortt, Lynne J. Lawrence, Peter J. Hudson, Kerry A. Breheney, Airlie J. McCoy, John Leslie Atwell
Publikováno v:
Protein Engineering, Design and Selection. 12:597-604
Single-chain Fv antibody fragments (scFvs) incorporate a polypeptide linker to tether the VH and VL domains together. An scFv molecule with a linker 5-12 residues long cannot fold into a functional Fv domain and instead associates with a second scFv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0f3852f9ec33b609c741513f3aa852
https://doi.org/10.1093/protein/12.7.597
https://doi.org/10.1093/protein/12.7.597
Autor:
Joseph N. Varghese, Anjali Sahasrabudhe, Lynne J. Lawrence, Jennifer L. McKimm-Breschkin, Peter M. Colman, V. Chandana Epa
Publikováno v:
Virology. 247(1):14-21
We have previously reported the isolation and characterization of an influenza virus variant with decreased sensitivity to the neuraminidase-specific inhibitor zanamivir. This variant, which has a mutation in the active site, Glu 119 Gly (E119G), has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb6e42b635b524c1740ae6fcb7584b7
Autor:
Peter Schuck, Michael F. Bailey, Geoffrey J. Howlett, Katrina J. Binger, Leanne M. Wilson, Chi L.L. Pham, Lynne J. Lawrence
Publikováno v:
Journal of molecular biology. 376(4)
Alzheimer's and several other diseases are characterized by the misfolding and assembly of protein subunits into amyloid fibrils. Current models propose that amyloid fibril formation proceeds via the self-association of several monomers to form a nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3550bb6a362dceab8d4458d3d4268356
https://pubmed.ncbi.nlm.nih.gov/18206908
https://pubmed.ncbi.nlm.nih.gov/18206908
Autor:
Yee-Foong Mok, Maree K. Staples, Lynne J. Lawrence, Cameron R. Stewart, Carl H. Schiesser, Anita A. Tseng, Kathryn J. Moore, Geoffrey J. Howlett, Jose N. Varghese
Publikováno v:
Biochemistry. 44(25)
The macrophage scavenger receptor CD36 plays a key role in the initiation of atherosclerosis through its ability to bind to and internalize oxidized low-density lipoproteins (oxLDL). Prompted by recent findings that the CD36 receptor also recognizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11a4b41beb3b5c962166ac98cf8948a
https://pubmed.ncbi.nlm.nih.gov/15966734
https://pubmed.ncbi.nlm.nih.gov/15966734
Autor:
Matthew A. Perugini, Christopher A. MacRaild, Menachem J. Gunzburg, Geoffrey J. Howlett, Lynne J. Lawrence, Cameron R. Stewart, V. Tirtaatmadja, Yee-Foong Mok, Justin J. Cooper-White
Publikováno v:
The Journal of biological chemistry. 279(20)
Amyloid deposits are proteinaceous extra-cellular aggregates associated with a diverse range of disease states. These deposits are composed predominantly of amyloid fibrils, the unbranched, beta-sheet rich structures that result from the misfolding a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061d65297f051730f608a558657272dc
https://pubmed.ncbi.nlm.nih.gov/15031287
https://pubmed.ncbi.nlm.nih.gov/15031287
Publikováno v:
Biochemistry. 41(48)
We have investigated the effect of disulfide cross-linking on amyloid formation by human apolipoprotein (apo) C-II. Three derivatives of apoC-II were generated by inserting a cysteine residue on either the N-terminus (C(N)-apoC-II), C-terminus (C(C)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64499b07390adc344d640f805398855f
https://pubmed.ncbi.nlm.nih.gov/12450397
https://pubmed.ncbi.nlm.nih.gov/12450397