Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Lynne E. Maquat"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract In non-polarized cells, nonsense-mediated mRNA decay (NMD) generally begins during the translation of newly synthesized mRNAs after the mRNAs are exported to the cytoplasm. Binding of the FMRP translational repressor to UPF1 on NMD targets m
Externí odkaz:
https://doaj.org/article/a80f886ce5ed45a0adcdfdb44a51326b
Autor:
Tatsuaki Kurosaki, Hitomi Sakano, Christoph Pröschel, Jason Wheeler, Alexander Hewko, Lynne E. Maquat
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Fragile X syndrome (FXS) is an intellectual disability attributable to loss of fragile X protein (FMRP). We previously demonstrated that FMRP binds mRNAs targeted for nonsense-mediated mRNA decay (NMD) and that FMRP loss results i
Externí odkaz:
https://doaj.org/article/a0a799aab3524b98be9f5f34a7a8b37c
Autor:
John L Rinn, Edward B. Chuong, Mark W. Feinberg, Junchao Shi, Jennifer Cable, Erwei Song, Matthew D. Simon, Qi Chen, Howard Y. Chang, Anna Marie Pyle, Sofia A. Quinodoz, Chun-Kan Chen, Edith Heard, Jonathan E. Henninger, Amanda E. Hargrove, Dhiraj Kumar, Jeremy E. Wilusz, Rory Johnson, Marco Marcia, Adelheid Lempradl, David L. Spector, Kannanganattu V. Prasanth, Joshua T. Mendell, Juan Pablo Unfried, Samie R. Jaffrey, Allison M Porman, Sean E. McGeary, Mukesh Kumar Lalwani, Murat C. Kalem, Ling-Ling Chen, Xuhang Liu, Tetsuro Hirose, Roza K. Przanowska, Xiaohua Shen, Lamia Wahba, Lin He, Sarah D. Diermeier, Lydia M. Contreras, Lynne E. Maquat
Publikováno v:
Ann N Y Acad Sci
The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b7e926c06d071808b4c085a712113a
https://doi.org/10.1111/nyas.14713
https://doi.org/10.1111/nyas.14713
Autor:
Hana Cho, Elizabeth T. Abshire, Maximilian W. Popp, Christoph Pröschel, Joshua L. Schwartz, Gene W. Yeo, Lynne E. Maquat
Publikováno v:
Molecular cell. 82(15)
Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA abundance, additional effectors that regulate NMD activity in mammalian cells continue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09393521d31c3541addbb2efae62a8ff
https://pubmed.ncbi.nlm.nih.gov/35675814
https://pubmed.ncbi.nlm.nih.gov/35675814
Autor:
Xavier Rambout, Hana Cho, Roméo Blanc, Qing Lyu, Joseph M. Miano, Joe V. Chakkalakal, Geoffrey M. Nelson, Hari K. Yalamanchili, Karen Adelman, Lynne E. Maquat
Publikováno v:
Molecular Cell. 83:186-202.e11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4672ce72c255ff730cf3b74c3ee3a6aa
https://doi.org/10.1016/j.molcel.2022.12.022
https://doi.org/10.1016/j.molcel.2022.12.022
Publikováno v:
Molecular Cell. 82:4564-4581.e11
How fragile X syndrome protein (FMRP) binds mRNAs and regulates mRNA metabolism remains unclear. Our previous work using human neuronal cells focused on mRNAs targeted for nonsense-mediated mRNA decay (NMD), which we showed are generally bound by FMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6da645058da73f004824c542287c94
https://doi.org/10.1016/j.molcel.2022.10.018
https://doi.org/10.1016/j.molcel.2022.10.018
Autor:
Sandra L. Wolin, Lynne E. Maquat
Publikováno v:
Science
The numerous quality control pathways that target defective ribonucleic acids (RNAs) for degradation play key roles in shaping mammalian transcriptomes and preventing disease. These pathways monitor most steps in the biogenesis of both noncoding RNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa786acab6a433eaa14c299afa24ad6
https://doi.org/10.1126/science.aax2957
https://doi.org/10.1126/science.aax2957
Autor:
Yoon Ki Kim, Lynne E. Maquat
Publikováno v:
RNA. 25:407-422
Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a means of post-transcriptional gene control. Control can be for the purpose of ensuring t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b04ce64106877b2b7733530e2b3a290
https://doi.org/10.1261/rna.070136.118
https://doi.org/10.1261/rna.070136.118
Autor:
Reyad A. Elbarbary, Lynne E. Maquat
Publikováno v:
Methods. 152:18-22
MicroRNAs (miRNAs) comprise a class of small non-coding RNAs that regulate the stability and/or translatability of most protein-coding transcripts. Steady-state levels of mature miRNAs can be controlled through mechanisms that influence their biogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597f0d830f7c4f06c429dd5a702534d2
https://doi.org/10.1016/j.ymeth.2018.05.010
https://doi.org/10.1016/j.ymeth.2018.05.010
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 84:47-54
Mammalian cells have many quality-control mechanisms that regulate protein-coding gene expression to ensure proper transcript synthesis, processing, and translation. Should a step in transcript metabolism fail to fulfill requisite spatial, temporal,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c5b4c918b7c0dd0c551cf56296e61e
https://doi.org/10.1101/sqb.2019.84.040212
https://doi.org/10.1101/sqb.2019.84.040212