Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Lynne A. Murray"'
Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles
Autor:
Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects 3 million people worldwide. Senescence and small extracellular vesicles (sEVs) have been implicated in the pathogenesis of IPF, although how sEVs promote d
Externí odkaz:
https://doaj.org/article/454012ad2e384074825f22792ab6bd66
Autor:
Susan Monkley, Catherine Overed-Sayer, Helen Parfrey, Doris Rassl, Damian Crowther, Leire Escudero-Ibarz, Nicola Davis, Alan Carruthers, Richard Berks, Marisa Coetzee, Ewa Kolosionek, Maria Karlsson, Leia R. Griffin, Maryam Clausen, Graham Belfield, Cory M. Hogaboam, Lynne A. Murray
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration of
Externí odkaz:
https://doaj.org/article/140262651e644238bf169dc86b4b8869
Autor:
Agata Radwanska, Christopher Travis Cottage, Antonio Piras, Catherine Overed-Sayer, Carina Sihlbom, Ramachandramouli Budida, Catherine Wrench, Jane Connor, Susan Monkley, Petra Hazon, Holger Schluter, Matthew J. Thomas, Cory M. Hogaboam, Lynne A. Murray
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unmet medical need. It is characterized by formation of scar tissue leading to a progressive and irreversible decline in lung function. IPF is associated with repeated injury, which may alte
Externí odkaz:
https://doaj.org/article/893273a899624c7f8501668b4c65941b
Autor:
Miriam S. Hohmann, David M. Habiel, Milena S. Espindola, Guanling Huang, Isabelle Jones, Rohan Narayanan, Ana Lucia Coelho, Justin M. Oldham, Imre Noth, Shwu-Fan Ma, Adrianne Kurkciyan, Jonathan L. McQualter, Gianni Carraro, Barry Stripp, Peter Chen, Dianhua Jiang, Paul W. Noble, William Parks, John Woronicz, Geoffrey Yarranton, Lynne A. Murray, Cory M. Hogaboam
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant repair that diminishes lung function via mechanisms that remain poorly understood. CC chemokine receptor (CCR10) and its ligand CCL28 were both elevated in IPF compared with normal dono
Externí odkaz:
https://doaj.org/article/33394c66fec3438285f38cc27a7b8ace
Autor:
Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associated with epithelial
Externí odkaz:
https://doaj.org/article/40130925c55a4bc29eb4f09272bb4f31
Autor:
Marina R. Hadjicharalambous, Benoit T. Roux, Carol A. Feghali-Bostwick, Lynne A. Murray, Deborah L. Clarke, Mark A. Lindsay
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed
Externí odkaz:
https://doaj.org/article/f816e922d03f4362a08ae74ed5979629
Autor:
Victoria Ptasinski, Susan J. Monkley, Karolina Öst, Markus Tammia, Catherine Overed-Sayer, Petra Hazon, Darcy E. Wagner, Lynne A. Murray
Repeated injury of the lung epithelium is proposed to be a main driver of idiopathic pulmonary fibrosis (IPF). However, none of the available therapies target the epithelium and there is a limited amount of human models of fibrotic epithelial damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f01dfdb4ac23bbdb138c14b2d754519e
https://doi.org/10.1101/2022.06.15.496102
https://doi.org/10.1101/2022.06.15.496102
Autor:
Victoria Ptasinski, Susan J Monkley, Karolina Öst, Markus Tammia, Hani N Alsafadi, Catherine Overed-Sayer, Petra Hazon, Darcy E Wagner, Lynne A Murray
Publikováno v:
Life Science Alliance. 6:e202201853
Repeated injury of the lung epithelium is proposed to be the main driver of idiopathic pulmonary fibrosis (IPF). However, available therapies do not specifically target the epithelium and human models of fibrotic epithelial damage with suitability fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77aeff0a9ad517575a54ca28ff964fe4
https://doi.org/10.26508/lsa.202201853
https://doi.org/10.26508/lsa.202201853
Autor:
Katerina Koether, Valérie Besnard, Hilary Sandig, Alan Carruthers, Elena Miranda, Sabine Grootenboer-Mignot, Camille Taillé, Sylvie Chevret, Dominique Valeyre, Hilario Nunes, Dominique Israel-Biet, Wei Keat Lim, Vincent Cottin, Dominic Corkill, Claire Dobson, Maria Groves, Franco Ferraro, Edouard Guenzi, Ling Huang, Michal Sulikowski, Arnaud Mailleux, Lynne Anne Murray, Thomas Mustelin, Ian Strickland, Matthew A. Sleeman, Bruno Crestani
Publikováno v:
European Respiratory Journal. 61:2102381
Several reports have highlighted a potential role of autoreactive B-cells and autoantibodies that correlates with increased disease severity in patients with idiopathic pulmonary fibrosis (IPF). Here we show that patients with IPF have an altered B-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95358d2839982a50572e71334e6b82e4
https://doi.org/10.1183/13993003.02381-2021
https://doi.org/10.1183/13993003.02381-2021
Autor:
Lynne Anne Murray
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2016)
Externí odkaz:
https://doaj.org/article/db1c5677b818431f974a68a39dcdb0fa