Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lynnae M. Smith"'
Autor:
Amanda C. Crisostomo, Loan Dang, Jyothi L. Digambaranath, Andrea C. Klaver, David A. Loeffler, Jeremiah J. Payne, Lynnae M. Smith, Adam L. Yokom, John M. Finke
Publikováno v:
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
The data here consists of time-dependent experimental parameters from chemical and biophysical methods used to characterize Aβ monomeric reactants as well as soluble oligomer and amyloid fibril products from a slow (3–4 week) assembly reaction und
Externí odkaz:
https://doaj.org/article/70189ab93d914f0ea3b12dee76f4bd0a
Publikováno v:
Journal of Neural Transmission. 123:179-187
Leucine-rich repeat kinase 2 (LRRK2) gene mutations are the most common genetic cause of Parkinson's disease (PD). CSF specimens from LRRK2 + PD patients and healthy LRRK2 mutation carriers are, therefore, useful for biomarker studies. This study exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9403d56460c782135e55c7ae72866230
https://doi.org/10.1007/s00702-015-1479-0
https://doi.org/10.1007/s00702-015-1479-0
Autor:
John M. Finke, Lynnae M. Smith, David A. Loeffler, Loan Dang, Adam L. Yokom, Amanda C. Crisostomo, Jeremiah J. Payne, Jyothi L. Digambaranath, Andrea C. Klaver
Publikováno v:
Data in Brief
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
The data here consists of time-dependent experimental parameters from chemical and biophysical methods used to characterize Aβ monomeric reactants as well as soluble oligomer and amyloid fibril products from a slow (3–4 week) assembly reaction und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963d9127e70314edf466791d06173849
http://europepmc.org/articles/PMC4560727
http://europepmc.org/articles/PMC4560727
Publikováno v:
Experimental Gerontology. 67:15-18
Phosphorylation of multiple amino acids on tau protein (“hyperphosphorylation”) is required for the development of tau pathology in Alzheimer's disease. Administration of anti-tau antibodies to transgenic “tauopathy mice” has been shown to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83af505404e6e4bc79b0a9d5b8d55d74
https://doi.org/10.1016/j.exger.2015.04.010
https://doi.org/10.1016/j.exger.2015.04.010
Autor:
Adam L. Yokom, Lynnae M. Smith, Amanda C. Crisostomo, Andrea C. Klaver, Jyothi L. Digambaranath, Loan Dang, David A. Loeffler, Jeremiah J. Payne, John M. Finke
Publikováno v:
Analytical Biochemistry. 481:43-54
Surface plasmon resonance was used to investigate the kinetics, affinity, and specificity of binding between anti-Aβ (beta-amyloid) IgG antibodies and oligomeric Aβ. Two factors were needed to accurately characterize the IgG binding kinetics. First
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8c0616e4a79afd7589195216ba60f4
https://doi.org/10.1016/j.ab.2015.03.032
https://doi.org/10.1016/j.ab.2015.03.032
Publikováno v:
International Immunopharmacology. 21:279-282
The effects of intravenous immunoglobulin (IVIG) products are being evaluated in Alzheimer's disease (AD) patients. IVIG contains antibodies to tau protein, the main constituent of neurofibrillary tangles (NFTs). Tau has microtubule binding domain (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9000a251c0bc705a4fe6b3ea1f723e
https://doi.org/10.1016/j.intimp.2014.05.009
https://doi.org/10.1016/j.intimp.2014.05.009
Publikováno v:
International Immunopharmacology. 16:424-428
Intravenous immunoglobulin (IVIG) products are prepared from plasma immunoglobulins from healthy donors. Pilot studies suggest that IVIG may stabilize cognitive functioning in patients with mild-to-moderate Alzheimer's disease. This study measured an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3007cbd63bc5a528cf0ca827431e4aa
https://doi.org/10.1016/j.intimp.2013.04.034
https://doi.org/10.1016/j.intimp.2013.04.034
Publikováno v:
Immunology Letters. 154:7-11
Intravenous immunoglobulin (IVIG) products are being investigated as possible therapeutic agents for mild cognitive impairment and Alzheimer's disease (AD). Anti-Aβ antibodies have been measured by ELISA in unfractionated IVIG products and in affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac0ef41c8f4f139fb5af698b55b34f5
https://doi.org/10.1016/j.imlet.2013.07.008
https://doi.org/10.1016/j.imlet.2013.07.008
Publikováno v:
International immunopharmacology. 14(4)
α-Synuclein is thought to contribute to the pathogenesis of Parkinson's disease (PD). It is the main protein in Lewy bodies, the pathognomonic inclusion bodies in the PD substantia nigra, and mutations which increase its aggregation and/or expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5f49f90adff7b419c249ae5abfdb1d
https://pubmed.ncbi.nlm.nih.gov/23026444
https://pubmed.ncbi.nlm.nih.gov/23026444
Autor:
David A. Loeffler, David A. Bennett, Mary P. Coffey, Andrea C. Klaver, Lynnae M. Smith, John M. Finke, Loan Dang
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 8, Iss 1, p 93 (2011)
Journal of Neuroinflammation, Vol 8, Iss 1, p 93 (2011)
Background The literature contains conflicting results regarding the status of serum anti-Aβ antibody concentrations in Alzheimer's disease (AD). Reduced levels of these antibodies have been suggested to contribute to the development of this disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94570fba9a30af4980229be2e7bb179c
https://pubmed.ncbi.nlm.nih.gov/21827691
https://pubmed.ncbi.nlm.nih.gov/21827691