Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lynn W. Maines"'
Publikováno v:
International Journal of Nephrology and Renovascular Disease.
Lynn W Maines, Cecelia L Green, Staci N Keller, Leo R Fitzpatrick, Charles D Smith Apogee Biotechnology Corporation, Hummelstown, PA, USACorrespondence: Charles D Smith, Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fc73c8de31a9d3cd2c971db33a66d2
https://www.dovepress.com/the-sphingosine-kinase-2-inhibitor-opaganib-protects-against-acute-kid-peer-reviewed-fulltext-article-IJNRD
https://www.dovepress.com/the-sphingosine-kinase-2-inhibitor-opaganib-protects-against-acute-kid-peer-reviewed-fulltext-article-IJNRD
Autor:
Charles D Smith, Lynn W Maines, Staci N Keller, Vered Katz Ben-Yair, Reza Fathi, Terry F Plasse, Mark L Levitt
Publikováno v:
Drug design, development and therapy. 16
The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive humanitarian and economic stress across the world. Although antivirals active against mild disease have been identified recently, new drugs to treat moderate and severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c5b4443d4e5c50df53f269f4800ede
https://pubmed.ncbi.nlm.nih.gov/35855741
https://pubmed.ncbi.nlm.nih.gov/35855741
Autor:
Lynn W, Maines, Randy S, Schrecengost, Yan, Zhuang, Staci N, Keller, Ryan A, Smith, Cecelia L, Green, Charles D, Smith
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13191
Exposure to ionizing radiation (IR) is a lingering threat from accidental or terroristic nuclear events, but is also widely used in cancer therapy. In both cases, host inflammatory responses to IR damage normal tissue causing morbidity and possibly m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a08f6a7dfa60c9dbc82eb55ed8cd13
https://doi.org/10.3390/ijms232113191
https://doi.org/10.3390/ijms232113191
Autor:
Randy S. Schrecengost, Ryan A. Smith, Staci N. Keller, Cecelia L. Green, Charles D. Smith, Lynn W. Maines, Yan Zhuang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:107-116
Glycogen synthase kinase-3s (GSK3α and GSK3β) are constitutively active protein kinases that target over 100 substrates, incorporate into numerous protein complexes, and regulate such vital cellular functions as proliferation, apoptosis, and inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5895fb458b6fac8e07fe077ca0be280e
https://doi.org/10.1124/jpet.117.245738
https://doi.org/10.1124/jpet.117.245738
Autor:
Tricia A. Bentz, Susan L. Cusack, Charles D. Smith, Keisuke Shirai, Yan Zhuang, Kate Anderton, Carolyn D. Britten, Steven H. Chin, Besim Ogretmen, Elizabeth Garrett-Mayer, Melanie B. Thomas, Alan Brisendine, Lynn W. Maines
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(16)
Purpose: Sphingosine kinases (SK1 and SK2) regulate tumor growth by generating the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). This phase I study investigated the safety, pharmacokinetics, pharmacodynamics, and antitumor activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16533c2d5bc89970115840570d927d45
https://pubmed.ncbi.nlm.nih.gov/28420720
https://pubmed.ncbi.nlm.nih.gov/28420720
Publikováno v:
Pharmacology. 87:135-143
Background/Aims: Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation and chondrocyte apoptosis, which may involve aberrant sphingolipid metabolism. ABC294640 is a compound that selectively inhibits sphingo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e74f909a709d21d14243eef2e41570
https://doi.org/10.1159/000323911
https://doi.org/10.1159/000323911
Publikováno v:
Inflammopharmacology. 18:73-85
Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn’s disease. Trinitrobenzen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac051dee7e26dcf3d032aac77c6f3250
https://doi.org/10.1007/s10787-010-0032-x
https://doi.org/10.1007/s10787-010-0032-x
Autor:
Cecelia L. Green, Charles D. Smith, Lynn W. Maines, Yan Zhuang, Ryan A. Smith, Staci N. Keller, Randy S. Schrecengost
Publikováno v:
Molecular Cancer Therapeutics. 17:B190-B190
Background: Several established chemotherapy drugs, including vinca alkaloids and paclitaxel, block tumor cell division by disrupting microtubule dynamics, ultimately leading to apoptosis. For decades, these drugs have remained central components for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29e709d8cd3816a8254ef4e7e05d9806
https://doi.org/10.1158/1535-7163.targ-17-b190
https://doi.org/10.1158/1535-7163.targ-17-b190
Autor:
Robert A. Hoerr, Walter A. Koltun, Leo R. Fitzpatrick, Lynn W. Maines, Jeffrey S. Small, Eileen F. Bostwick
Publikováno v:
British Journal of Nutrition. 100:530-541
We examined the in vitro and in vivo effects of a probiotic, Escherichia coli strain M-17 (EC-M17), on NF-kappaB signalling, cytokine secretion and efficacy in dextran sulfate sodium (DSS)-induced murine colitis. NF-kappaB signalling was assessed usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c308e6c1ff2250d151c59879fc6120
https://doi.org/10.1017/s0007114508930373
https://doi.org/10.1017/s0007114508930373
Autor:
Charles D. Smith, John J. Upson, Staci N. Keller, Lynn W. Maines, Kevin J. French, Leo R. Fitzpatrick, Yan Zhuang, Zuping Xia
Publikováno v:
Digestive Diseases and Sciences. 53:997-1012
A critical step in the mechanism of action of inflammatory cytokines is the stimulation of sphingolipid metabolism, including activation of sphingosine kinase (SK), which produces the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74d1758c6f161288f1dd5ab2524fa57
https://doi.org/10.1007/s10620-007-0133-6
https://doi.org/10.1007/s10620-007-0133-6