Adaptive immune changes associate with clinical progression of Alzheimer’s disease

Autor: Lynn van Olst, Alwin Kamermans, Sem Halters, Susanne M. A. van der Pol, Ernesto Rodriguez, Inge M. W. Verberk, Sanne G. S. Verberk, Danielle W. R. Wessels, Carla Rodriguez-Mogeda, Jan Verhoeff, Dorine Wouters, Jan Van den Bossche, Juan J. Garcia-Vallejo, Afina W. Lemstra, Maarten E. Witte, Wiesje M. van der Flier, Charlotte E. Teunissen, Helga E. de Vries

Publikováno v: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)

Abstract Background Alzheimer’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of peripheral immune cells in the disease, but the underlying mechanisms remain unclear. Methods We comprehensively mapped

Externí odkaz: https://doaj.org/article/bbeaac8f21914591a0b29202e34aed6d

Contribution of Gut Microbiota to Immunological Changes in Alzheimer’s Disease

Autor: Lynn van Olst, Sigrid J.M. Roks, Alwin Kamermans, Barbara J. H. Verhaar, Anne M. van der Geest, Majon Muller, Wiesje M. van der Flier, Helga E. de Vries

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Emerging evidence suggests that both central and peripheral immunological processes play an important role in the pathogenesis of Alzheimer’s disease (AD), but regulatory mechanisms remain unknown. The gut microbiota and its key metabolites are kno

Externí odkaz: https://doaj.org/article/d37ef0dacf984a6cbe4dab51caca4db7

Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment

Autor: Natalie Piehl, Lynn van Olst, Abhirami Ramakrishnan, Victoria Teregulova, Brooke Simonton, Ziyang Zhang, Emma Tapp, Divya Channappa, Hamilton Oh, Patricia M. Losada, Jarod Rutledge, Alexandra N. Trelle, Elizabeth C. Mormino, Fanny Elahi, Douglas R. Galasko, Victor W. Henderson, Anthony D. Wagner, Tony Wyss-Coray, David Gate

Publikováno v: Cell. 185(26)

Cerebrospinal fluid (CSF) contains a tightly regulated immune system. However, knowledge is lacking about how CSF immunity is altered with aging or neurodegenerative disease. Here, we performed single-cell RNA sequencing on CSF from 45 cognitively no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f217ab364318591d3af758444def5a4
https://pubmed.ncbi.nlm.nih.gov/36516855

Aging blood factors promote CD8+ T cell infiltration in the adult mouse brain

Autor: Lynn van Olst, Alwin Kamermans, Susanne van der Pol, Lianne Hulshof, Roland van Dijk, Danielle Vonk, Marijn Schouten, Maarten Witte, Helga de Vries, Jinte Middeldorp

Aging coincides with major changes in brain immunity that aid in a decline in neuronal function. Here, we postulate that systemic, pro-aging factors contribute to immunological changes that occur within the brain during aging. To investigate this hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20747ee63588f012df2feff392b88093
https://doi.org/10.21203/rs.3.rs-1266205/v1

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

Autor: Lynn van Olst, Sabela Rodríguez-Lorenzo, Carla Rodriguez-Mogeda, Alwin Kamermans, Susanne MA van der Pol, Ernesto Rodríguez, Gijs Kooij, Helga E de Vries

Publikováno v: eLife, 11:e73849. eLife Sciences Publications Limited
Rodríguez-Lorenzo, S, van Olst, L, Rodriguez-Mogeda, C, Kamermans, A, van der Pol, S M A, Rodríguez, E, Kooij, G & de Vries, H E 2022, ' Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis ', eLife, vol. 11, e73849 . https://doi.org/10.7554/eLife.73849

Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. Despite research efforts to define the role of various immune cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef866329af3b534fb459b186be88dfa2
https://research.vumc.nl/en/publications/43c9c4c2-2cab-48c3-87e2-d072a6ced38e