Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lynn Symonds"'
Autor:
Lynn Symonds, Ming Yu, YuHong Zhang, Fang-Shu Ou, Tyler J. Zemla, Kelly Carter, Monica Bertagnolli, Federico Innocenti, Linda JW Bosch, Gerrit A Meijer, Beatriz Carvalho, William M. Grady, Stacey A. Cohen
Publikováno v:
Epigenetics, Vol 17, Iss 12, Pp 1715-1725 (2022)
Aberrantly methylated genes contribute to the landscape of epigenetic alterations in colorectal adenocarcinoma. The global CpG Island methylator phenotype (CIMP) and individually methylated genes are potential prognostic/predictive biomarkers. Resear
Externí odkaz:
https://doaj.org/article/fedc615c145b49aa9716d591e2847ecb
Autor:
Jean J. Zhao, Gordon B. Mills, Lewis C. Cantley, Andrea P. Myers, Jane Li, Emmanuelle Di Tomaso, Sauveur-Michel Maira, Roderick T. Bronson, Carolynn E. Ohlson, Lynn Symonds, Erbo Xu, Fan Zhang, Pixu Liu, Hailing Cheng
Supplementary Figure 1. Representative images of metastases found in the liver (left panel) and peritoneal wall (right panel) of Pten loxp/loxp Lkb1loxp/loxp female mice bearing Pten Lkb1-deficient endometrial tumors. Supplementary Figure 2. Genotypi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141c33b3e988dce43e938b6523fd1871
https://doi.org/10.1158/0008-5472.22399914.v1
https://doi.org/10.1158/0008-5472.22399914.v1
Autor:
Jean J. Zhao, Gordon B. Mills, Lewis C. Cantley, Andrea P. Myers, Jane Li, Emmanuelle Di Tomaso, Sauveur-Michel Maira, Roderick T. Bronson, Carolynn E. Ohlson, Lynn Symonds, Erbo Xu, Fan Zhang, Pixu Liu, Hailing Cheng
Summary of disease phenotypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f80b931cf0ebbd2bedc68631b043a8
https://doi.org/10.1158/0008-5472.22399911
https://doi.org/10.1158/0008-5472.22399911
Autor:
Ursa Brown-Glaberman, Hannah M. Linden, Lynn Symonds, Jennifer M. Specht, Eve T. Rodler, Isaac C. Jenkins, Xiaoyu Chai, Georgiana K. Ellis, Pavani Chalasani, Jinny Riedel, Brenda F. Kurland, Julie Gralow, Alison Stopeck, Qian Wu, Vijayakrishna V K Gadi
Publikováno v:
Clin Breast Cancer
INTRODUCTION Neoadjuvant chemotherapy is standard treatment for locally advanced (LABC) or inflammatory breast cancer (IBC). We hypothesized adding sunitinib, a tyrosine kinase inhibitor with anti-tumor and anti-angiogenic activity, to an anthracycli
Autor:
Lynn Symonds, Erik Konnick, Funda Vakar-Lopez, Heather H. Cheng, Michael T. Schweizer, Peter S. Nelson, Colin C. Pritchard, Bruce Montgomery
Publikováno v:
JCO Precision Oncology.
Autor:
Stacey A. Cohen, Lynn Symonds
Publikováno v:
Gastroenterology Report
A curative-intent approach may improve survival in carefully selected patients with oligometastatic colorectal cancer. Aggressive treatments are most frequently administered to patients with isolated liver metastasis, though they may be judiciously c
Autor:
William J. Muller, Carlos L. Arteaga, Hailing Cheng, Pixu Liu, Erbo Xu, Lynn Symonds, Ian E. Krop, Eric P. Winer, Nan Lin, Jean J. Zhao, Thomas M. Roberts, Carolynn E. Ohlson, Adam J. Isabella
Publikováno v:
Oncogene
Human breast cancers that have HER2 amplification/overexpression frequently carry PIK3CA mutations, and are often associated with a worse prognosis. However, the role of PIK3CA mutations in the initiation and maintenance of these breast cancers remai
Autor:
Vijayakrishna K. Gadi, Carol Van Haelst, Eve T. Rodler, Quan Vicky Wu, Mary W. Redman, Isaac C. Jenkins, Jeanne Anderson, Kelsey Baker, Julie R. Gralow, Mitchell Garrison, Larissa A. Korde, Julie C. Smith, Brenda F. Kurland, Jennifer M. Specht, Lynn Symonds, Hannah M. Linden
Publikováno v:
Clinical breast cancer. 19(2)
Introduction Angiogenesis and epidermal growth factor receptor signaling are potential therapeutic targets in triple negative breast cancer (TNBC). We hypothesized that targeting these critical pathways would prolong progression-free survival with fi
Autor:
Lewis C. Cantley, Gordon B. Mills, Jane Li, Roderick T. Bronson, Pixu Liu, Fan Zhang, Carolynn E. Ohlson, Sauveur Michel Maira, Erbo Xu, Emmanuelle di Tomaso, Lynn Symonds, Andrea P. Myers, Hailing Cheng, Jean J. Zhao
Publikováno v:
Cancer Research. 74:15-23
Signals from the tumor suppressors PTEN and LKB1 converge on mTOR to negatively regulate its function in cancer cells. Notably, both of these suppressors are attenuated in a significant fraction of human endometrial tumors. In this study, we generate
Autor:
William M. Grady, George Fountzilas, Lynn Symonds, George Pentheroudakis, Dimitrios G. Pectasides, Kelsey Baker, Stacey A. Cohen, Christos Poulios, Lisa K. Koch, George Papaxoinis, Konstantine T. Kalogeras, Kelly T. Carter, Mary W. Redman, Ming Yu, Ralph Wirtz
Publikováno v:
Journal of Clinical Oncology. 37:567-567
567 Background: MACC1, part of the HGF-MET pathway, drives proliferation and regulation of MET expression in vitro. In vivo, MACC1 is associated with tumor progression and studies suggest greater MACC1 expression is associated with resistance to plat