Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Lynn Roth"'
Autor:
Cédric H. G. Neutel, Callan D. Wesley, Cindy van Loo, Céline Civati, Freke Mertens, Michelle Zurek, Anja Verhulst, Isabel Pintelon, Winnok H. De Vos, Bart Spronck, Lynn Roth, Guido R. Y. De Meyer, Wim Martinet, Pieter-Jan Guns
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Calciprotein particles (CPPs) are an endogenous buffering system, clearing excessive amounts of Ca2+ and PO4 3- from the circulation and thereby preventing ectopic mineralization. CPPs circulate as primary CPPs (CPP1), which are small spheri
Externí odkaz:
https://doaj.org/article/ec219c4be4484da5ac08fecee8cd9237
Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable
Autor:
Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer
Publikováno v:
Artery Research, Vol 30, Iss 1, Pp 1-8 (2024)
Abstract Translating vascular aging research from bench to bedside presents both significant opportunities and challenges. This paper summarizes insights from a roundtable discussion at the Artery 23 conference, featuring perspectives from basic scie
Externí odkaz:
https://doaj.org/article/8d44e4319d774384bad0520ec448c890
Autor:
Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cédric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1171 (2022)
Gasdermin D (GSDMD) is the key executor of pyroptotic cell death. Recent studies suggest that GSDMD-mediated pyroptosis is involved in atherosclerotic plaque destabilization. We report that cleaved GSDMD is expressed in macrophage- and smooth muscle
Externí odkaz:
https://doaj.org/article/18ea2978b0f34161b7e274ce89d7fbfe
Publikováno v:
Artery Research, Vol 26, Iss Supplement 1 (2020)
Background: Acetylsalicylic acid (ASA) is used in secondary prevention of cardiovascular disease (CVD) because of its antithrombotic effects. We investigated whether ASA has additional therapeutic value by preventing the progression of inflammation a
Externí odkaz:
https://doaj.org/article/210ca2e295b64f96bc55de5b044d1299
Autor:
Dorien G. De Munck, Sofie De Moudt, Lynn Roth, Guido R. Y. De Meyer, Wim Martinet, Paul Fransen
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Autophagy is an important cellular survival process that enables degradation and recycling of defective organelles and proteins to maintain cellular homeostasis. Hence, defective autophagy plays a role in many age-associated diseases, such as atheros
Externí odkaz:
https://doaj.org/article/e4a30be751ee4e93bf7ed5ad2fa84340
Autor:
Lynn Roth, Miche Rombouts, Dorien M. Schrijvers, Besa Emini Veseli, Wim Martinet, Guido R. Y. De Meyer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 404 (2021)
Acetylsalicylic acid (ASA) is widely used in secondary prevention of cardiovascular (CV) disease, mainly because of its antithrombotic effects. Here, we investigated whether ASA can prevent the progression of vessel wall remodelling, atherosclerosis,
Externí odkaz:
https://doaj.org/article/11333efe3fda41c98aab68620758efbf
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1731 (2021)
Statins (hydroxymethyl-glutaryl-CoA-reductase inhibitors) lower procarboxypeptidase U (proCPU, TAFI, proCPB2). However, it is challenging to prove whether this is a lipid or non-lipid-related pleiotropic effect, since statin treatment decreases chole
Externí odkaz:
https://doaj.org/article/04f1f8ee3622409b9d5d554eb53e2936
Autor:
Jhana O. Hendrickx, Sofie De Moudt, Elke Calus, Wim Martinet, Pieter-Jan D. F. Guns, Lynn Roth, Peter P. De Deyn, Debby Van Dam, Guido R. Y. De Meyer
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6656 (2021)
Increasing epidemiological evidence highlights the association between systemic insulin resistance and Alzheimer’s disease (AD). As insulin resistance can be caused by high-stress hormone levels and since hypercortisolism appears to be an important
Externí odkaz:
https://doaj.org/article/1d85c304985641a5b8dc26727b5e1314
Autor:
Nina Hermans, Bieke Steenput, Lynn Roth, Guido De Meyer, Claudia Nunes dos Santos, Kateřina Valentová, Maija Dambrova, Tess De Bruyne
Publikováno v:
Proceedings, Vol 11, Iss 1, p 40 (2019)
Cardiovascular diseases are the major cause of mortality, with 17.9 million deaths/year worldwide and 3.9 million deaths/year in Europe, representing a cost to the EU economy of €210 billion/year [1,2]. [...]
Externí odkaz:
https://doaj.org/article/3a126fbf51d2416aad5af079d10b812c
Autor:
Tess De Bruyne, Bieke Steenput, Lynn Roth, Guido R. Y. De Meyer, Claudia Nunes dos Santos, Kateřina Valentová, Maija Dambrova, Nina Hermans
Publikováno v:
Nutrients, Vol 11, Iss 3, p 578 (2019)
Increased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellula
Externí odkaz:
https://doaj.org/article/2fb27d7917844b9da9490e116e889e38