Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Lynn Neff"'
Autor:
Yukari Shiwaku, Lynn Neff, Kenichi Nagano, Ken-Ichi Takeyama, Joost de Bruijn, Michel Dard, Francesca Gori, Roland Baron
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132903 (2015)
Biphasic calcium phosphates (BCPs), consisting of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), exhibit good biocompatibility and osteoconductivity, maintaining a balance between resorption of the biomaterial and formation of new bone. We
Externí odkaz:
https://doaj.org/article/fe1aebde3b7a424ab70e1bf0c791edef
Autor:
Virginia-Jeni A. Parkman, Yoshihito Ishihara, Vincent T. Carpentier, Noriko Ide, Lynn Neff, Kenichi Nagano, Sutada Lotinun, Dorothy Hu, Roland Baron, Mary L. Bouxsein, Pamela Dann, Riku Kiviranta, Daniel J. Brooks, Francesca Gori, John J. Wysolmerski
Publikováno v:
J Clin Invest
Lactation induces bone loss to provide sufficient calcium in the milk, a process that involves osteoclastic bone resorption but also osteocytes and perilacunar resorption. The exact mechanisms by which osteocytes contribute to bone loss remain elusiv
Autor:
William N. Addison, Francesca Gori, Shoichiro Kokabu, Lynn Neff, William C. Horne, Takuma Matsubara, Roland Baron
Publikováno v:
The Journal of Biological Chemistry
Deletion of c-Src, a ubiquitously expressed tyrosine kinase, results in osteoclast dysfunction and osteopetrosis, in which bones harden into “stone.” In contrast, deletion of the genes encoding other members of the Src family kinase (SFK) fails t
Autor:
Antonios O. Aliprantis, Andrew K. Stewart, Sebastien Robert Stephens, Seth L. Alper, Lynn Neff, Gary E. Shull, Serhan Zenger, Kelly Tsang, Roland Baron, Fabienne Coury
Publikováno v:
Proceedings of the National Academy of Sciences. 110:2163-2168
Bone remodeling requires osteoclasts to generate and maintain an acidified resorption compartment between the apical membrane and the bone surface to solubilize hydroxyapatite crystals within the bone matrix. This acidification process requires ( i )
Autor:
Walter Witke, Nah-Young Shin, Kenichi Nagano, Roland Baron, Detina Zalli, Lynn Neff, Francesca Gori
The adhesion of osteoclasts (OCs) to bone and bone resorption require the assembly of specific F-actin adhesion structures, the podosomes, and their dense packing into a sealing zone. The OC-specific formation of the sealing zone requires the interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1e52ee8078d6b85075c2fab49e46a9
https://europepmc.org/articles/PMC5070801/
https://europepmc.org/articles/PMC5070801/
Autor:
Lynn Neff, Hiroaki Saito, William C. Horne, Eric Hesse, Kei Yamana, Riku Kiviranta, D. Toben, Georg N. Duda, Valérie Geoffroy, Azeddine Atfi, Diego Correa, Roland Baron
Publikováno v:
The Journal of Cell Biology
Zfp521 regulates osteoblast development during lineage commitment and osteoblast maturation by suppressing Runx2 transcriptional activity.
Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteobl
Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteobl
Publikováno v:
Journal of Bone and Mineral Research. 3:69-80
The question of whether any of the agents known to activate bone resorption in vivo or in organ cultures acts directly on the osteoclast or via intermediate target cells that secondarily secrete locally paracrine factors is important for our understa
Publikováno v:
Molecular Biology of the Cell. 20:4021-4030
c-Cbl and Cbl-b are highly conserved adaptor proteins that participate in integrin signaling, regulating cytoskeletal organization, motility, and bone resorption. Deletion of both c-Cbl and Cbl-b in mice leads to embryonic lethality, indicating that
Autor:
Cecile Itzsteink, Arata Nakajima, Lynn Neff, Naga Suresh Adapala, Riccardo Chiusaroli, Roland Baron, William C. Horne, Archana Sanjay
Publikováno v:
Journal of Bone and Mineral Research. 24:1162-1172
Cbl proteins are multifunctional adaptor molecules that modulate cellular activity by targeting the ubiquitylating system, endocytic complexes, and other effectors to a wide variety of regulatory proteins, especially activated receptor and nonrecepto
Publikováno v:
Endocrinology. 150:135-143
Obesity and osteoporosis are major health issues affecting millions of individuals. Transgenic mice overexpressing ΔFosB, an activator protein-1 transcription factor, under the control of the enolase 2 (ENO2) promoter exhibit both an increase in bon