Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lynn McKeown"'
Autor:
Dapeng Wang, Sabina D. Wiktor, Chew W. Cheng, Katie J. Simmons, Ashley Money, Lucia Pedicini, Asya Carlton, Alexander L. Breeze, Lynn McKeown
Publikováno v:
COVID, Vol 4, Iss 7, Pp 1087-1099 (2024)
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 692 million cases worldwide and nearly 7 million deaths (August 2023). Severe COVID-19 is characterise
Externí odkaz:
https://doaj.org/article/d5d43bc856d646b5ae61a3f61de9d1c3
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Rab46 is a novel Ca2+-sensing Rab GTPase shown to have important functions in endothelial and immune cells. The presence of functional Ca2+-binding, coiled-coil and Rab domains suggest that Rab46 will be important for coupling rapid response
Externí odkaz:
https://doaj.org/article/c6b1162121634a90b1082cf02940df59
Autor:
Beibei Wu, Laura Rice, Jennifer Shrimpton, Dylan Lawless, Kieran Walker, Clive Carter, Lynn McKeown, Rashida Anwar, Gina M Doody, Sonal Srikanth, Yousang Gwack, Sinisa Savic
Publikováno v:
eLife, Vol 10 (2021)
CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca2+-NFAT and JNK-AP1 pathways. CRACR2A has been linked to h
Externí odkaz:
https://doaj.org/article/3bc52deffd5148cea866655819e240e0
Blood flow regulates vascular function by generating wall shear stress which impacts endothelial cell (EC) physiology. Whilst high laminar shear stress (HSS) maintains the functional integrity of the vasculature, low oscillatory shear stress (LOSS) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::127c528a8c0b71fa6de16e6fb5de69c4
https://doi.org/10.1101/2023.05.26.542527
https://doi.org/10.1101/2023.05.26.542527
Mast cells are infamous for mediating allergic and inflammatory diseases due to their capacity of rapidly releasing a wide range of inflammatory mediators stored in cytoplasmic granules. However, mast cells also have several important physiological r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6ff0c230cb3876fb501595a39c9f578
https://doi.org/10.1101/2023.03.13.532191
https://doi.org/10.1101/2023.03.13.532191
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Rab46 is a novel Ca2+-sensing Rab GTPase shown to have important functions in endothelial and immune cells. The presence of functional Ca2+-binding, coiled-coil and Rab domains suggest that Rab46 will be important for coupling rapid responses to sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e25a012cc1b0c52c72ce56f04f1e733
https://doaj.org/article/c6b1162121634a90b1082cf02940df59
https://doaj.org/article/c6b1162121634a90b1082cf02940df59
Autor:
Dapeng Wang, Sabina D Wiktor, Chew W Cheng, Katie J Simmons, Ashley Money, Lucia Pedicini, Asya Carlton, Alexander L Breeze, Lynn McKeown
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 235 million cases worldwide and 4.8 million deaths (October 2021). Severe COVID-19 is characterised in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::821837b5ddcf366f1fd7147833750c24
https://doi.org/10.1101/2022.01.17.22269412
https://doi.org/10.1101/2022.01.17.22269412
Autor:
Laura Rice, Beibei Wu, Jennifer Shrimpton, Dylan Lawless, Kieran Walker, Clive Carter, Lynn McKeown, Rashida Anwar, Gina M Doody, Sonal Srikanth, Yousang Gwack, Sinisa Savic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e502c9b3a8a5404ee5f554c6973a1e1
https://doi.org/10.7554/elife.72559.sa2
https://doi.org/10.7554/elife.72559.sa2
Autor:
Beibei, Wu, Laura, Rice, Jennifer, Shrimpton, Dylan, Lawless, Kieran, Walker, Clive, Carter, Lynn, McKeown, Rashida, Anwar, Gina M, Doody, Sonal, Srikanth, Yousang, Gwack, Sinisa, Savic
Publikováno v:
eLife
CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca2+-NFAT and JNK-AP1 pathways. CRACR2A has been linked to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1e8e658828060a351c00eb81efe3890
https://pubmed.ncbi.nlm.nih.gov/34908525
https://pubmed.ncbi.nlm.nih.gov/34908525
Autor:
Katarzyna Marszalek, Raphael G. Slip, Hannah J. Gaunt, Lesley A. Wilson, Diego Sobradillo, Fiona Bartoli, Izzy Jayasinghe, David J. Beech, Katarina T. Miteva, Shruthi Deivasigamani, Lucia Pedicini, Lynn McKeown
Publikováno v:
Journal of Cell Biology. 218:2232-2246
Endothelial cells selectively release cargo stored in Weibel-Palade bodies (WPBs) to regulate vascular function, but the underlying mechanisms are poorly understood. Here we show that histamine evokes the release of the proinflammatory ligand, P-sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc0a52402adc3e6e45255f420512243
https://doi.org/10.1083/jcb.201810118
https://doi.org/10.1083/jcb.201810118