Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lynn Machemer"'
Publikováno v:
Journal of Chromatography B. 835:62-70
The ocular metabolism of an siRNA duplex, SIRNA-027, was examined by ion-pair reversed-phase liquid chromatography (IP-RP-LC) coupled to electrospray ionization mass spectrometry (ESI-MS). The RNA duplex was injected intraocularly into the eyes of Ne
Publikováno v:
Rapid communications in mass spectrometry : RCM. 19(12)
Liquid chromatography/mass spectrometry (LC/MS) was used as a method for analyzing the metabolites of a model short interfering RNA (siRNA) duplex. The model siRNA duplex incorporated oligonucleotide stabilizing and protecting chemistries as these ha
Autor:
David Morrissey, Jennifer A. Lockridge, Kristi Jensen, Vasant Jadhav, Chandra Vargeese, Barry Polisky, Kimberly Hartsough, Narendra K. Vaish, Keith Bowman, Wendy Breen, Lucinda Shaw, Chris S. Shaffer, Susan Radka, Lynn Machemer, Ian MacLachlan, Adam Judge, Lloyd Jeffs, Karin Blanchard, Shawn Zinnen
Publikováno v:
Nature biotechnology. 23(8)
The efficacy of lipid-encapsulated, chemically modified short interfering RNA (siRNA) targeted to hepatitis B virus (HBV) was examined in an in vivo mouse model of HBV replication. Stabilized siRNA targeted to the HBV RNA was incorporated into a spec