Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lynn M. Vella"'
Autor:
Michael S. Denison, Lynn M. Vella
Publikováno v:
Archives of biochemistry and biophysics. 277(2)
2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD, dioxin) produces many of its biological effects by binding to a soluble, intracellar protein (the Ah receptor (AhR)). The hepatic AhR, from a variety of species, is present in low salt cytosol as a form wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178228417725963cf56ab80ad5abc596
https://pubmed.ncbi.nlm.nih.gov/2155580
https://pubmed.ncbi.nlm.nih.gov/2155580
Autor:
Allan B. Okey, Lynn M. Vella
Publikováno v:
Biochemical Pharmacology. 33:531-538
Binding of 3-methylcholanthrene (MC),2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), and other “MC-type” inducers to cytosolic Ah receptor sites is the first specific step in induction of aryl hydrocarbon hydroxylase (AHH; cytochrome P 1 −450) by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6af8156b82ef1f9390f049efa042a9
https://doi.org/10.1016/0006-2952(84)90303-4
https://doi.org/10.1016/0006-2952(84)90303-4
Publikováno v:
Journal of Biological Chemistry. 261:3987-3995
Molecular properties of cytosolic Ah receptors from livers of Sprague-Dawley rats and C57BL/6N mice were assessed by velocity sedimentation on sucrose gradients and by gel permeation chromatography on Sephacryl S-300. Analyses were done under conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0bcb8e3b4ed407f45ed82d69430da6d
https://doi.org/10.1016/s0021-9258(17)35611-9
https://doi.org/10.1016/s0021-9258(17)35611-9
Publikováno v:
Journal of Biological Chemistry. 261:10189-10195
In structure and general mode of action, the Ah receptor is very similar to the receptors for steroid hormones. Molybdate previously has been shown to be highly effective at preserving ligand-binding function in steroid receptors during their exposur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a839f3947c9c6f32cb5701aa9cf8f2
https://doi.org/10.1016/s0021-9258(18)67509-x
https://doi.org/10.1016/s0021-9258(18)67509-x
Publikováno v:
Archives of Biochemistry and Biophysics. 273:458-465
Rat hepatic cytosol was treated with alkaline phosphatase in order to determine if dephosphorylation altered the ability of Ah receptor to bind 2,3,7,8-[ 3 H]tetrachlorodibenzo- p -dioxin (TCDD). Glucocorticoid receptor was studied for comparison. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c4041b2cd94c752e5652f4475113eb
https://doi.org/10.1016/0003-9861(89)90505-5
https://doi.org/10.1016/0003-9861(89)90505-5
Publikováno v:
Canadian journal of physiology and pharmacology. 62(10)
Ah receptor in hepatic cytosols from adult cynomolgus monkeys (Macaca fasicularis) was identified and quantitated by its binding of the highly toxic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the carcinogens 3-methylcholanthrene, benzo[a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521e7c04ea74f0fc0fb6f902042fc99e
https://pubmed.ncbi.nlm.nih.gov/6095980
https://pubmed.ncbi.nlm.nih.gov/6095980
Publikováno v:
Archives of biochemistry and biophysics. 252(2)
Cytosol from rodent liver was exposed to a variety of sulfhydryl-modifying reagents to determine if the cytosolic Ah receptor contained reactive sulfhydryl groups that were essential for preservation of the receptor's ligand binding function. At a 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd77380de738093593473fd111a65fd8
https://pubmed.ncbi.nlm.nih.gov/3028264
https://pubmed.ncbi.nlm.nih.gov/3028264
Autor:
Lynn M. Vella, Allan B. Okey
Publikováno v:
European journal of biochemistry. 127(1)
The Ah receptor, which mediates induction of aryl hydrocarbon hydroxylase (cytochrome P1-450), previously was identified and characterized using 2,3,7,8-tetrachloro[3H]dibenzo-p-dioxin as the radioligand. Polycyclic aromatic hydrocarbons such as 3-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afac9d59192921a4a42faed29577e7d8
https://pubmed.ncbi.nlm.nih.gov/7140758
https://pubmed.ncbi.nlm.nih.gov/7140758
Publikováno v:
Canadian journal of physiology and pharmacology. 67(6)
In many species systemic toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is manifested by a generalized wasting syndrome accompanied by a variety of specific organ changes including atrophy of the thymus and spleen. TCDD toxicity in most tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdc7d7d92c42495c7632e33a91aac8d
https://pubmed.ncbi.nlm.nih.gov/2550120
https://pubmed.ncbi.nlm.nih.gov/2550120