Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Lynn M. Hartweck"'
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
The Arabidopsis thaliana glycosyl transferases SPINDLY (SPY) and SECRET AGENT (SEC) modify nuclear and cytosolic proteins with O-linked fucose or O-linked N-acetylglucosamine (O-GlcNAc), respectively. O-fucose and O-GlcNAc modifications can occur at
Externí odkaz:
https://doaj.org/article/7235ba59047a4ac293227dcf7d5fc682
Autor:
Felipe Kazmirczak, Lynn M. Hartweck, Neal T. Vogel, Jenna B. Mendelson, Anna K. Park, Rashmi M. Raveendran, Jin O-Uchi, Bong Sook Jhun, Sasha Z. Prisco, Kurt W. Prins
Publikováno v:
JACC Basic Transl Sci
Intermittent fasting (IF) extends life span via pleotropic mechanisms, but one important molecular mediator is adenosine monophosphate–activated protein kinase (AMPK). AMPK enhances lipid metabolism and modulates microtubule dynamics. Dysregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0d77ee9307c0c0de28b24c8344e50b
https://doi.org/10.1016/j.jacbts.2022.12.001
https://doi.org/10.1016/j.jacbts.2022.12.001
Autor:
Darko Bosnakovski, Sunny S. K. Chan, Olivia O. Recht, Lynn M. Hartweck, Collin J. Gustafson, Laura L. Athman, Dawn A. Lowe, Michael Kyba
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Facioscapulohumeral muscular dystrophy is a severe myopathy that is caused by abnormal activation of DUX4, and for which a suitable mouse model does not exist. Here, the authors generate a novel mouse model with titratable expression of DUX4, and sho
Externí odkaz:
https://doaj.org/article/9516fa4c1ad1467299b0aa2dfdddf207
Arabidopsis thalianahas two glycosyl transferases, SPINDLY (SPY) and SECRET AGENT (SEC), that modify nuclear and cytosolic protein with O-linked fucose and N-acetylglucosamine (GlcNAc), respectively. SPY interacts physically and genetically with GIGA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::678a8415b7f4fd679231dcc76163f77e
https://doi.org/10.1101/2023.04.13.536733
https://doi.org/10.1101/2023.04.13.536733
Autor:
Sasha Z. Prisco, Lynn M. Hartweck, Felipe Kazmirczak, Jenna B. Mendelson, Stephanie L. Deng, Satadru K. Lahiri, Xander H.T. Wehrens, Kurt W. Prins
Publikováno v:
bioRxiv
Right ventricular dysfunction (RVD) is a risk factor for mortality in multiple cardiovascular diseases, but approaches to combat RVD are lacking. Therapies used for left heart failure are largely ineffective in RVD, and thus the identification of mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fdb6f1d06eaa74c86cb1bd94208401
https://doi.org/10.1101/2023.02.07.527576
https://doi.org/10.1101/2023.02.07.527576
Autor:
Jenna B. Mendelson, Jacob D. Sternbach, Michelle J. Doyle, Lauren Mills, Lynn M. Hartweck, Walt Tollison, John P. Carney, Matthew T. Lahti, Richard W. Bianco, Rajat Kalra, Felipe Kazmirczak, Charles Hindmarch, Stephen L Archer, Kurt W. Prins, Cindy M. Martin
Publikováno v:
bioRxiv
Right ventricular failure (RVF) is a leading cause of morbidity and mortality in multiple cardiovascular diseases, but there are no approved treatments for RVF as therapeutic targets are not clearly defined. Contemporary transcriptomic/proteomic eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2dab5f715ca11157c7fc5c84ff0117
https://europepmc.org/articles/PMC9934613/
https://europepmc.org/articles/PMC9934613/
Autor:
Sasha Z. Prisco, Lynn M. Hartweck, Lauren Rose, Patricia D.A. Lima, Thenappan Thenappan, Stephen L. Archer, Kurt W. Prins
Publikováno v:
Circulation. Heart failure. 15(1)
Background:Right ventricular dysfunction (RVD) is the leading cause of death in pulmonary arterial hypertension (PAH), but no RV-specific therapy exists. We showed microtubule-mediated junctophilin-2 dysregulation (MT-JPH2 pathway) causes t-tubule di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fefc03bd599943cdc323891111a32b
https://pubmed.ncbi.nlm.nih.gov/35758045
https://pubmed.ncbi.nlm.nih.gov/35758045
Autor:
Abhijit Dandapat, Darko Bosnakovski, Lynn M. Hartweck, Robert W. Arpke, Kristen A. Baltgalvis, Derek Vang, June Baik, Radbod Darabi, Rita C.R. Perlingeiro, F. Kent Hamra, Kalpna Gupta, Dawn A. Lowe, Michael Kyba
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1484-1496 (2014)
Facioscapulohumeral muscular dystrophy (FSHD) is an enigmatic disease associated with epigenetic alterations in the subtelomeric heterochromatin of the D4Z4 macrosatellite repeat. Each repeat unit encodes DUX4, a gene that is normally silent in most
Externí odkaz:
https://doaj.org/article/20445cf0808e4af4a600615bb0b4246c
Autor:
Felipe Kazmirczak, Lynn M. Hartweck, Neal T. Vogel, Jenna B. Mendelson, Anna K. Park, Rashmi M. Raveendran, Jin O-Uchi, Bong Sook Jhun, Sasha Z. Prisco, Kurt W. Prins
Intermittent fasting (IF) extends lifespan via pleotropic mechanisms, but one important molecular mediator of the beneficial effects of IF is AMP-kinase (AMPK). AMPK enhances lipid metabolism and modulates microtubule dynamics. Dysregulation of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32160e0473c32b2fb0d42aa861dabed2
https://doi.org/10.1101/2022.03.07.483333
https://doi.org/10.1101/2022.03.07.483333
Author Correction: Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model
Autor:
Darko Bosnakovski, Sunny S. K. Chan, Olivia O. Recht, Lynn M. Hartweck, Collin J. Gustafson, Laura L. Athman, Dawn A. Lowe, Michael Kyba
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, an incorrect grant number, RO1 NS083549, was acknowledged. The correct grant number is RO1 AR055685. This error has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/eec0d9039c604248ae1370a120d7d21f