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pro vyhledávání: '"Lynn M. Alaeddine"'
Autor:
Frédéric Harb, Maysaa Hamza, Batoul Dia, Ramzi Sabra, Mirella El Khoury, Nadim S. Azar, Nahed Mogharbil, Lynn M. Alaeddine, Assaad A. Eid, Mohamed H. Noureldein
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 235
Diabetic cardiomyopathy (DCM) is a well-established complication of type 1 and type 2 diabetes associated with a high rate of morbidity and mortality. DCM is diagnosed at advanced and irreversible stages. Therefore, it is of utmost need to identify n
Publikováno v:
Current medicinal chemistry. 28(12)
Metabolic stress, transduced as an altered cellular redox and energy status, presents as the main culprit in many diseases, including diabetes. However, its role in the pathology of neurological disorders is still not fully elucidated. Metformin, a b
Autor:
Ahmed S.F. Belal, Rasha A. Nassra, Yasser S. Abdel-Ghany, Rana Alaaeddine, Lynn M. Alaeddine, Ahmed F. El-Yazbi, Ghandoura Moussa, Aly A. Hazzaa, Azza Ismail
Publikováno v:
European journal of medicinal chemistry. 144
Click chemistry was used to synthesize a new series of thioquinazolinone molecules equipped with propargyl moiety,1,2,3-triazolyl and isoxazolyl rings. Our design was based on merging pharmacophores previously reported to exhibit COX-2 inhibitory act