Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Lynn M Williams"'
Autor:
Vicky Nicolaidou, Mei Mei Wong, Andia N Redpath, Adel Ersek, Dilair F Baban, Lynn M Williams, Andrew P Cope, Nicole J Horwood
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39871 (2012)
A major therapeutic challenge is how to replace bone once it is lost. Bone loss is a characteristic of chronic inflammatory and degenerative diseases such as rheumatoid arthritis and osteoporosis. Cells and cytokines of the immune system are known to
Externí odkaz:
https://doaj.org/article/1b5a05d299a44e68b10c51f7847f5b30
Autor:
Dominique Davidson, Lorraine Harry, Lynn M. Williams, Chris Bainbridge, Manu Sood, Weilin Xie, Hai Fang, Bogdan Knezevic, Marisa Cabrita, Michael Sundstrӧm, Julian C. Knight, Sarah Bonham, Fiona E. McCann, Adam P. Cribbs, Roman Fischer, Jagdeep Nanchahal, Nan Yang, Leenart M Steenbeek, Thomas B. Layton, Marc Feldmann, Mingjun Zhang, David Warwick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fibrosis remains a major unmet medical need as therapeutic targets discovered in animal models have failed to translate. A major challenge for identifying novel targets is the limited availability of early-stage human disease tissue. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08d19dd786c0c58af7dc421950c39de
https://doi.org/10.1073/pnas.2004281117
https://doi.org/10.1073/pnas.2004281117
Publikováno v:
Civil Engineering Magazine. 90:52-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c567ffc9324234faffd9d3569f05703a
https://doi.org/10.1061/ciegag.0001470
https://doi.org/10.1061/ciegag.0001470
Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remains a major cause of morbidity and mortality and is also associated with many other disorders, including cancer and metabolic disease. In this review, we focus upon the micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c81eb141cf173e98ad7b1ac728c1c7c
https://ora.ox.ac.uk/objects/uuid:580e23e4-8817-48fe-87ce-5e9080162fff
https://ora.ox.ac.uk/objects/uuid:580e23e4-8817-48fe-87ce-5e9080162fff
Autor:
Henry Penn, Felix I.L. Clanchy, Jonas Bystrom, Federica Borghese, Trevor W. Stone, Graham Wells, Richard O. Williams, Serafim Kiriakidis, Dobrina N. Hull, Sandra Sacre, Peter C. Taylor, Attilia Balog, Lynn M. Williams, Rizgar A. Mageed
The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. Toll-like receptor (TLR) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864ace76d55f477346441101dc7af267
https://doi.org/10.1016/j.jaut.2021.102597
https://doi.org/10.1016/j.jaut.2021.102597
Autor:
Dominic Furniss, Marc Feldmann, Weilin Xie, Jagdeep Nanchahal, M Ng, Fiona E. McCann, Thomas B. Layton, Mingjun Zhang, Stephen N. Sansom, Marco Fritzsche, Lynn M. Williams, Marisa Cabrita, Huw Colin-York
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many of them. A major barrier for the identification of targets and successful clinical translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559226e09164015d21fecc9fff7a7933
https://pubmed.ncbi.nlm.nih.gov/32488016
https://pubmed.ncbi.nlm.nih.gov/32488016
Autor:
Dominic Furniss, Huw Colin-York, Fiona E. McCann, Mingjun Zhang, Marisa Cabrita, Thomas B. Layton, M Ng, Stephen N. Sansom, Jagdeep Nanchahal, Marco Fritzsche, Lynn M. Williams, Weilin Xie, Marc Feldmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many of them. A major barrier for the identification of targets and successful clinical translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e03342b261cac8da5c4cb3369b56f58
https://doi.org/10.1038/s41467-020-16264-y
https://doi.org/10.1038/s41467-020-16264-y
Autor:
Adam P. Cribbs, Yongjing Guo, Sundeept Bhalara, Bernard Gregory, Lih-Ling Lin, Marc Feldmann, Attila A. Seyhan, Yizheng Li, Ying Zhang, Christine Loreth, Lynn M. Williams, Peter C. Taylor, Fionula M. Brennan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
We profiled gene expression signatures to distinguish rheumatoid arthritis (RA) from non-inflammatory arthralgia (NIA), self-limiting arthritis (SLA), and undifferentiated arthritis (UA) as compared to healthy controls as novel potential biomarkers f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bccac40f02ddb5c763c49b32feaddb
https://doi.org/10.1038/s41598-020-63757-3
https://doi.org/10.1038/s41598-020-63757-3
Autor:
Thomas B. Layton, Marco Fritzsche, Fiona E. McCann, Dominic Furniss, Jagdeep Nanchahal, Weilin Xie, Marisa Cabrita, Lynn M. Williams, Cameron Brown, Huw Colin-York, Marc Feldmann
Publikováno v:
Biology Open
Biology Open, Vol 9, Iss 3 (2020)
Biology Open, Vol 9, Iss 3 (2020)
Mechanical force is a fundamental regulator of cell phenotype. Myofibroblasts are central mediators of fibrosis, a major unmet clinical need characterised by the deposition of excessive matrix proteins. Traction forces of myofibroblasts play a key ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb82eabdaf842fd58c49b5cb920dc76
https://doi.org/10.1242/bio.049809
https://doi.org/10.1242/bio.049809